DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gas and cest-32

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_504397.1	Gene:	cest-32 / 178909	WormBaseID:	WBGene00016862	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	510	Identity:	150/510 - (29%)
Similarity:	235/510 - (46%)	Gaps:	73/510 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 YDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDC-TYAREKPMQRNSITNA-----AEGS 109
            :|.:....:.|||||:.|:.||||:.|.....|....:| .|....|...:.|:|.     .|.:
Worm    31 HDDKIVNGYLGIPFAKAPICELRFKKPVEAEKWTKPLNCHKYGPGCPQSGHMISNLLPPGYREFA 95

  Fly   110 ED-CLYLNVYA---KRLESPKPLPVMVWIFGGGFQVGGASRELYGPDYFMK-----HDILLVTIN 165
            || ||.||::|   |..|.|..||:||:..||||::|.:|   ...||.:.     .|:::||.|
Worm    96 EDNCLNLNIFAPSWKSEEFPNGLPIMVYFHGGGFEIGFSS---MFDDYSLSGTLPLKDVIVVTAN 157

  Fly   166 YRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFGESAGGASTHILMQ 230
            ||||.|||::..|:..:  ||.||.||..||:||:|:|.||.|:|..:||.|.||||.|..:|..
Worm   158 YRVGPLGFMTTGDEVSR--GNYGLWDQTLALKWVQEHIKSFGGNPNIVTVCGTSAGGVSAGLLAL 220

  Fly   231 TEQARGLFHRAIVQSGSALCAWATQPDRKWPQ---RLGKELGYAGNLESEKELLEFFQQIPASKL 292
            :..:..||||.:..||||.|.::.:...:..:   ...|..||.|  |..:.|||:::..|.||.
Worm   221 SPHSNKLFHRFMAMSGSAFCEFSIRTKEQEAEIFRNFAKHHGYEG--EDSESLLEWYKSQPLSKF 283

  Fly   293 AQYCNSIVTQEEQRDYEILAFAPVIEPYVGDDCVIPKSQQEQLSSAWGNSIPMIIGGTSFEG--- 354
            .:     ....|::....|.|.|..:   ||  ..||...|....|  ..:..:.....:||
Worm   284 QE-----TATFEKKASGFLTFIPNFD---GD--FFPKPFDELSREA--PKLDAMATVDEYEGLGF 336

  Fly   355 LFSYRTTLDDPLYMLSAFEAIIPKQVRDAIDKEELAEMVRRLKKSYFDDPDRASMELYECLHILS 419
            |..:::..:|...:.|:|.:.:   |.:|:|.:      :|:.:.|..:.|:...:..|...|..
Worm   337 LTMFQSRRNDMDIIKSSFGSDV---VENAVDVQ------KRIMEFYMKNIDKNDDKAVEKRLIQL 392

  Fly   420 IKNFWHDIH--RTLLARLAYATNLPTYLYRFD-----MDSPHFNHYRILKCGKKVRGVCHADDIS 477
            |.:.|.:|.  .|:.....|.:|  .||..||     .:.|:...:       ..:...|..::.
Worm   393 ISDSWFNIGALETVKTSTKYGSN--AYLGSFDYYNMGSNDPYATWF-------PFKAANHGSELK 448

  Fly   478 YMFYGILSSKLDKNSP---EYRTIERLVGMWTSFATTGDPNCEIIAPVKWDPLRP 529
            ||    |...:.|.||   |::.|:.:..:..:|...|:|| .|..|..|....|
Worm   449 YM----LGEGMGKFSPIEEEFKVIDMMGTLTANFVKYGNPN-GINGPELWKKYTP 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	150/510 (29%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	49/112 (44%)
cest-32	NP_504397.1	COesterase	15..516	CDD:278561	150/510 (29%)
cest-32	NP_504397.1	Aes	<104..>227	CDD:223730	53/127 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157250
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.640