DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gas and cest-12

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_499576.4	Gene:	cest-12 / 176642	WormBaseID:	WBGene00013540	Length:	850	Species:	Caenorhabditis elegans

Alignment Length:	351	Identity:	107/351 - (30%)
Similarity:	163/351 - (46%)	Gaps:	55/351 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GQLKGQQ------RRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQ-GVRDCTYAREKPM 97
            |.::|:|      :..||.|:. .:|.|||:.|.|||.||.:.|||.:.:. .:.|.||.|.|..
Worm    42 GSVQGRQVNLGNDQSQLYSGQA-NAFTGIPYCQAPVGNLRLQPPQPLNQFNTTLHDATYFRPKCP 105

  Fly    98 QRNSITNAAEGSEDCLYLNVYAKRLESPKP-LPVMVWIFG-GGFQVGGA--SRELYGPDYFMKHD 158
            |.|:   ....:|||||||||..:..:... |.|:|.|.| .||..||.  ::|.......::..
Worm   106 QLNA---GGPTNEDCLYLNVYTPQAGNTNANLSVLVLIDGSNGFSNGGCDQNQEKGIISNLVQRQ 167

  Fly   159 ILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFGESAG-- 221
            |::||:.||:|.|||.:....  .:..|.|:.||:||:||:|..|.:|.|:|..|||.|:..|
Worm   168 IVVVTMQYRIGALGFFTTYTN--SVQSNLGMLDQVQAMRWIKTEIVNFGGNPNQITVAGQDDGAC 230

  Fly   222 GASTHILMQTEQARGLFHRAIVQSGSALCAW-------------ATQPDRKWPQ-RLG-KELGYA 271
            ..|.|.|  :..::.||::|||||||....:             .|.|...:.| ..| ...||.
Worm   231 AVSAHCL--SPMSQNLFNQAIVQSGSVYSCYNPTPAVPTNPQVQVTTPRPMYDQSNTGYGNAGYQ 293

  Fly   272 GNLESEKELLEFFQQI---------PASKLAQ-YCNSIVTQEEQRDYEILAFAPVIEPYVGDDCV 326
            .|...:.:.:......         |:.:||| .||  ::.::..:.:.......::.|..|..|
Worm   294 NNYGYQPQPITSTSSYNSANAQYDDPSQQLAQTLCN--ISPDQWNNGQTQNIQNCMKNYTVDFFV 356

  Fly   327 IPKSQQEQLSSAWGNSIPMIIGGTSF 352
              ..|....::.|     ||:..|||
Worm   357 --NQQPGGPNATW-----MIVRDTSF 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	107/351 (30%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	39/110 (35%)
cest-12	NP_499576.4	Abhydrolase	37..>400	CDD:389770	107/351 (30%)
cest-12	NP_499576.4	Abhydrolase	<678..774	CDD:389770
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.900