DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gas and Ces3b

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_653094.2	Gene:	Ces3b / 13909	MGIID:	3644960	Length:	571	Species:	Mus musculus

Alignment Length:	584	Identity:	174/584 - (29%)
Similarity:	255/584 - (43%)	Gaps:	137/584 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IIGHKVVQYKLGTGQTKELATKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPS 81
            :.|.||:|        .|:.|..|:::|:|............|.||||||.|||.|||.||.||.
Mouse    29 VTGPKVIQ--------PEVDTPLGRVRGRQVGVKDTDRMVNVFLGIPFAQAPVGPLRFSAPLPPQ 85

  Fly    82 SWQGVRDCTYAREKPM---QRNSITNAAEG----------SEDCLYLNVYAKRLESPKPL----- 128
            .|:||||.:.  ..||   ....:.|:..|          |||||.||:|     ||..:
Mouse    86 PWEGVRDASI--NPPMCLQDVEKMINSRFGLNEKIKIFPISEDCLTLNIY-----SPTEITAGDK 143

  Fly   129 -PVMVWIFGGGFQVG------GASRELYGPDYFMKHDILLVTINYRVGVLGFLSLKDKELKIPGN 186
             ||||||.||...||      |::...||       |:::||:.||:|:.||||..||.:  |||
Mouse   144 RPVMVWIHGGSLLVGSSTSQDGSALAAYG-------DVVVVTVQYRLGIFGFLSTGDKHM--PGN 199

  Fly   187 AGLKDQIQALRWVKENIASFNGDPESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCA 251
            .|..|.:.|||||:.|||.|.|||..:|:||.||||.....|..:..:.|||||||.|||  :..
Mouse   200 RGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGMIVSSLFLSPISAGLFHRAISQSG--IVT 262

  Fly   252 WATQPDRK-WPQRLGKELGYAGNLESEKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEILAFAP 315
            .....|.| ||:........|....|..||::             |   :.|:|.:|  ::....
Mouse   263 TIMMEDMKPWPEAQNFANSVACGSASPAELVQ-------------C---LLQKEGKD--LIKQKN 309

  Fly   316 VIEPYVGDDCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSY-------------RTTLDDPLY 367
            |...|:.:|...|:..::.|:.....::|.::|.|:.|  |.:             ..:.:|.|.
Mouse   310 VNISYIVNDSFFPQRPEKLLADQQFPTVPYLLGVTNHE--FGWLLLKSLNILDKLEHLSREDLLE 372

  Fly   368 MLSAFEAI--IPKQVRDAIDKEELAEMVRRLKKSYFDDPDRASMELYECLHILSIKNFWHDIHRT 430
            :...|.||  :|.::...:..|            |.|:....|...|....:|...:|
Mouse   373 ISRPFLAIMEVPPEIMPTVIDE------------YLDNGSDQSATRYAFQELLGDISF------- 418

  Fly   431 LLARLAYATNL-----PTYLYRFDMDSPHFNHYR--ILKCGKKVRGVCHADDISYMFYGILSSKL 488
            ::..|.::..|     |.:||.|......|..::  .:|..       ||.:.|::|.|...:
Mouse   419 IIPTLNFSKYLRDAGCPVFLYEFQHTPSSFAKFKPAWVKAD-------HASENSFVFGGPFLT-- 474

  Fly   489 DKNS----PEYRTIER-----LVGMWTSFATTGDPNCEIIAPVKWDPLRPGGVENCLNIADGLE 543
            |::|    ||....|:     ::..|:.||.||:||.:.:.|  |..|..  :|..|.|  |||
Mouse   475 DESSLLAFPEATEEEKQLSLTMMAQWSQFARTGNPNGKGLPP--WPQLNQ--LEQYLEI--GLE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	164/562 (29%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	50/116 (43%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	171/577 (30%)
		Aes	75..>245	CDD:223730	76/185 (41%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832486
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740