DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gas and clt

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	199/552 - (36%)
Similarity:	299/552 - (54%)	Gaps:	46/552 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ELATKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVR-DCTYAREKPM 97
            ::..|.|.|.|:|:: |.:|..|.||.|:|:|:|||||||||:|:|...:|... ||:.......
  Fly    21 KVPVKQGVLVGRQKK-LVNGLEYNSFLGVPYAEPPVGELRFRSPRPLERFQKQELDCSKEGNVSY 84

  Fly    98 QRNSITNAAEGSEDCLYLNVYAKRLESPK-PLPVMVWIFGGGFQVGGASRELYGPDYFMKHDILL 161
            ||:..|....||||||:|||||.:::|.: ||||||||.||||..|..:.:.:.|...|:.::::
  Fly    85 QRDPFTLEVAGSEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAKLMEQEVIV 149

  Fly   162 VTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFGESAGGASTH 226
            ||:|||:|.||||||.::  .|.||.|||||..||.||:||||||||||.::|:|||||||:|.|
  Fly   150 VTLNYRLGALGFLSLPEE--GIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVH 212

  Fly   227 ILMQTEQARGLFHRAIVQSGSALCAWATQ---PDRKWPQRLGKELG---YAGNLESEKELLEFFQ 285
            :......|:.|||:||:|||:|...|..|   |.:  .:||.:.||   :.|:   .|.||.|.|
  Fly   213 LHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAK--TRRLAELLGGGDFGGD---SKALLTFLQ 272

  Fly   286 QIPASKLAQYCNS--IVTQEEQRDYEILAFAPVIEPYVGDDCVIPKSQQEQL--SSAWGNSIPMI 346
            ...|:..|...|:  :::.:|:|.:...||.||:|.....|..:.:...|.:  ....| |:|:|
  Fly   273 SEKATPTAILANTLKVLSPDERRRHLPFAFKPVVEDSSSPDRFLEQDIMELMHKKDCLG-SMPVI 336

  Fly   347 IGGTSFEGLFSYRTTLDDPLYMLSAFE----AIIPKQVRDAIDKE--ELAEMVRRLKKSYFDDPD 405
            :|..|.|||    ..:......|.|:|    .::|:.:  .:|.:  |..|....::..:|:...
  Fly   337 MGYNSAEGL----AIVVKAKQKLEAYEDDLARLVPRNL--VLDPQAPEAQEAASDIRAFFFNGQA 395

  Fly   406 RASMELYECLHILSIKNFWHDIHRTLLARLAYATNLPTYLYRFDMDSPHFNHYRILKCGKKVRGV 470
            .:...:...:.:.|..:|..|:.|.:....:..|..|.|.||.|..... |.|:.:...:.:|||
  Fly   396 LSKENMDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVGGR-NLYKKIFQNEDLRGV 459

  Fly   471 CHADDISYMFYGILSSKLDKNSPEYRTIERLVGMWTSFATTGDPNCEIIAPVKWDPL-RPGGVE- 533
            .|||||.|:|. :...:.:.|..:....|||..||.:||..|.|     :|: |.|: :|...|
  Fly   460 AHADDICYLFQ-MAGDETEMNRDDLMVTERLCEMWANFARDGKP-----SPI-WKPVKKPHNGEP 517

  Fly   534 ---NCLNIADGLEFIPLPESKQFVVWDSFYTR 562
               :||.|...|:....|:.::...|.|.|.|
  Fly   518 IQLDCLLIDRELKMCSNPDGERMDFWRSMYRR 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	190/522 (36%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	59/105 (56%)
clt	NP_536784.1	COesterase	22..543	CDD:278561	195/543 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.870