Protein Alignment gas and Nlgn2

DIOPT Version :9

• Sequence 1: NP_611678.1
• Gene: gas / 37572
• FlyBaseID: FBgn0034736
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_446444.1
• Gene: Nlgn2 / 117096
• RGDID: 621118
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 624
• Identity: 181/624 - (29%)
• Similarity: 266/624 - (42%)
• Gaps: 158/624 - (25%)

  Fly    27 LGTGQTKE-----LATKYGQLKGQQRRTLYDGE---PYYSFEGIPFAQPPVGELRFRAPQPPSSW 83
            ||.|...|     :.|.||:::|.:|.  .:.|   |...|.|:|:|.||:|..||:.|:.|:||
  Rat    31 LGLGSLGEERFPVVNTAYGRVRGVRRE--LNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASW 93

  Fly    84 QGVRDCTYAREKPMQ-------------------RNSITNAAEGSEDCLYLNVYAKRLESP---- 125
            .|||:.|.......|                   ..:.|.....||||||||:|....:.|
  Rat    94 PGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKK 158

  Fly   126 ------KP----------LPVMVWIFGGGFQVG------GASRELYGPDYFMKHDILLVTINYRV 168
                  .|          .|||:::.||.:..|      |:....||       ::::.|:|||:
  Rat   159 RDEATLNPPDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYG-------NVIVATLNYRL 216

  Fly   169 GVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFGESAGGASTHILMQTEQ 233
            |||||||..|:..|  ||.||.||||||||:.||||.|.||||.||:||..||.:..::|:.:..
  Rat   217 GVLGFLSTGDQAAK--GNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHH 279

  Fly   234 ARGLFHRAIVQSGSALCAWAT--QPDRKWPQRLGKELGYAGNLESEKELLEFFQQIPASKLAQYC 296
            :.|||.:||.|||:|:.:|:.  || .|:.:.|..::|.  :.|...|.:|..::..:.:|
  Rat   280 SEGLFQKAIAQSGTAISSWSVNYQP-LKYTRLLAAKVGC--DREDSTEAVECLRRKSSREL---- 337

  Fly   297 NSIVTQEEQRDYEILAFAPVIE-PYVGDDCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGL-FSYR 359
               |.|:.|.....:||.||:: ..|.||..|...|.|.|      :..|:||....||| |...
  Rat   338 ---VDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFL------NYDMLIGVNQGEGLKFVED 393

  Fly   360 TTLDDPLYMLSAFEAIIPKQVRDAIDKEELAEMVRR-LKKSYFDDPDRASMELYECLHILSIKNF 423
            :...:.....|||:..:...|.:.....|..:::|. :|..|.|..||.:.|:.
  Rat   394 SAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMR----------- 447

  Fly   424 WHDIHRTLLARL--------AYAT-------NLPTYLYRFDMDSPHFNHYRILKCGKKVR----G 469
                .:||||..        |.||       ..|.|.|.|      ::|     |..:.|    .
  Rat   448 ----RKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTF------YHH-----CQAEGRPEWAD 497

  Fly   470 VCHADDISYMF-------YGILSSKLDKNSPEYRTIERLVGMWTSFATTGDPNCEIIAPVKWDPL 527
            ..|.|::.|:|       ..:......||......:  ::..||:||.|||||..:....|:...
  Rat   498 AAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQPVPQDTKFIHT 560

  Fly   528 RPGGVENCLNIADGLEFIPLPESKQFVVWDSFYTRESLY 566
            :|...|.                   |||..|.::|..|
  Rat   561 KPNRFEE-------------------VVWSKFNSKEKQY 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	173/589 (29%)
		Aes	<117..>222	CDD:223730	51/130 (39%)
Nlgn2	NP_446444.1	COesterase	42..601	CDD:395084	177/613 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336471
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840