Protein Alignment gas and CEL

DIOPT Version :10

• Sequence 1: NP_611678.1
• Gene: gas / 37572
• FlyBaseID: FBgn0034736
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_001798.3
• Gene: CEL / 1056
• HGNCID: 1848
• Length: 753
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 172/557 - (30%)
• Similarity: 255/557 - (45%)
• Gaps: 124/557 - (22%)

  Fly    26 KLGTGQTKELATKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCT 90
            |||.     :.|:.|.::|..::....|:....|:|||||.|...   ...|||...|||.....
Human    22 KLGA-----VYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKA---LENPQPHPGWQGTLKAK 78

  Fly    91 YAREKPMQRNSITNAAEGSEDCLYLNVYAK--RLESPKPLPVMVWIFGGGFQVG---GA---SRE 147
            ..:::.:|.....::..|.|||||||::..  |.:..:.||||:||:||.|.:|   ||   :..
Human    79 NFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNY 143

  Fly   148 LY-GPDYFMKHDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPE 211
            || |.:...:.::::||.|||||.|||||..|..|  |||.||:||..|:.|||.|||:|.|||.
Human   144 LYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANL--PGNYGLRDQHMAIAWVKRNIAAFGGDPN 206

  Fly   212 SITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPD-----RKWPQRLGKELGYA 271
            :||:|||||||||..:...:...:||..|||.|||.||..|..|.:     :|..:::|..:|.|
Human   207 NITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDA 271

  Fly   272 GNLE-----SEKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEIL---AFAPVIEPYVGDDCVIP 328
            ..:.     ::...|....::|.:.|              :|.:|   .|.|||:   ||  .||
Human   272 ARMAQCLKVTDPRALTLAYKVPLAGL--------------EYPMLHYVGFVPVID---GD--FIP 317

  Fly   329 KSQQEQLSSAWGNSIPMIIGGTSFEG-LF-----------SYRTTLDDPLYMLSAFEAIIPKQVR 381
            .......::|  ..|..|.|..:.:| :|           :.:.|.:|...::|.|  .|.|.:|
Human   318 ADPINLYANA--ADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEF--TITKGLR 378

  Fly   382 DAIDKEELAEMVRRLKKSYFD--------DPDRASMELYECLHILSIKNFWHDI----------- 427
            .|              |:.||        ||.:.:.:       .::.:|..|:
Human   379 GA--------------KTTFDVYTESWAQDPSQENKK-------KTVVDFETDVLFLVPTEIALA 422

  Fly   428 -HRTLLARLAYATNLPTYLYRFDMDSPHFNHYRILKCGKKVRGVCHADDISYMFYGILSSKLDKN 491
             ||      |.|.:..||.|.       |:|...:....|..|..|||||.|:| |...:.....
Human   423 QHR------ANAKSAKTYAYL-------FSHPSRMPVYPKWVGADHADDIQYVF-GKPFATPTGY 473

  Fly   492 SPEYRTIER-LVGMWTSFATTGDPNC-EIIAPVKWDP 526
            .|:.||:.: ::..||:||.|||||. :...|..|:|
Human   474 RPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEP 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	31..529	CDD:395084	169/552 (31%)
CEL	NP_001798.3	Heparin-binding	21..121		32/106 (30%)
		COesterase	26..542	CDD:395084	169/548 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..753
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745
		Mucin-like	584..677	CDD:464997
		Mucin-like	639..731	CDD:464997