DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gas and CEL

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001798.3	Gene:	CEL / 1056	HGNCID:	1848	Length:	753	Species:	Homo sapiens

Alignment Length:	557	Identity:	172/557 - (30%)
Similarity:	255/557 - (45%)	Gaps:	124/557 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KLGTGQTKELATKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCT 90
            |||.     :.|:.|.::|..::....|:....|:|||||.|...   ...|||...|||.....
Human    22 KLGA-----VYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKA---LENPQPHPGWQGTLKAK 78

  Fly    91 YAREKPMQRNSITNAAEGSEDCLYLNVYAK--RLESPKPLPVMVWIFGGGFQVG---GA---SRE 147
            ..:::.:|.....::..|.|||||||::..  |.:..:.||||:||:||.|.:|   ||   :..
Human    79 NFKKRCLQATITQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNY 143

  Fly   148 LY-GPDYFMKHDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPE 211
            || |.:...:.::::||.|||||.|||||..|..|  |||.||:||..|:.|||.|||:|.|||.
Human   144 LYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANL--PGNYGLRDQHMAIAWVKRNIAAFGGDPN 206

  Fly   212 SITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPD-----RKWPQRLGKELGYA 271
            :||:|||||||||..:...:...:||..|||.|||.||..|..|.:     :|..:::|..:|.|
Human   207 NITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDA 271

  Fly   272 GNLE-----SEKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEIL---AFAPVIEPYVGDDCVIP 328
            ..:.     ::...|....::|.:.|              :|.:|   .|.|||:   ||  .||
Human   272 ARMAQCLKVTDPRALTLAYKVPLAGL--------------EYPMLHYVGFVPVID---GD--FIP 317

  Fly   329 KSQQEQLSSAWGNSIPMIIGGTSFEG-LF-----------SYRTTLDDPLYMLSAFEAIIPKQVR 381
            .......::|  ..|..|.|..:.:| :|           :.:.|.:|...::|.|  .|.|.:|
Human   318 ADPINLYANA--ADIDYIAGTNNMDGHIFASIDMPAINKGNKKVTEEDFYKLVSEF--TITKGLR 378

  Fly   382 DAIDKEELAEMVRRLKKSYFD--------DPDRASMELYECLHILSIKNFWHDI----------- 427
            .|              |:.||        ||.:.:.:       .::.:|..|:
Human   379 GA--------------KTTFDVYTESWAQDPSQENKK-------KTVVDFETDVLFLVPTEIALA 422

  Fly   428 -HRTLLARLAYATNLPTYLYRFDMDSPHFNHYRILKCGKKVRGVCHADDISYMFYGILSSKLDKN 491
             ||      |.|.:..||.|.       |:|...:....|..|..|||||.|:| |...:.....
Human   423 QHR------ANAKSAKTYAYL-------FSHPSRMPVYPKWVGADHADDIQYVF-GKPFATPTGY 473

  Fly   492 SPEYRTIER-LVGMWTSFATTGDPNC-EIIAPVKWDP 526
            .|:.||:.: ::..||:||.|||||. :...|..|:|
Human   474 RPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVPTHWEP 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	170/555 (31%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	55/113 (49%)
CEL	NP_001798.3	Heparin-binding	21..121		32/106 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..753
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142719
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.640