DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gas and Ces1d

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_444430.2	Gene:	Ces1d / 104158	MGIID:	2148202	Length:	565	Species:	Mus musculus

Alignment Length:	580	Identity:	172/580 - (29%)
Similarity:	253/580 - (43%)	Gaps:	115/580 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCTYAREKPM-QRNS 101
            ||..|:|..       :|...|.|:|||:||:|.|||..|||...|..|::.|  ...|| .:::
Mouse    36 KYVNLEGFT-------QPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTT--SYPPMCSQDA 91

  Fly   102 I---------TNAAEG-----SEDCLYLNVYAKR-LESPKPLPVMVWIFGGGFQVGGASRELYGP 151
            :         ||..|.     ||||||||:|... |.....|||||||.|||..|||||  .|..
Mouse    92 VGGQVLSELFTNRKENIPLQFSEDCLYLNIYTPADLTKNSRLPVMVWIHGGGLVVGGAS--TYDG 154

  Fly   152 DYFMKHD-ILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITV 215
            .....|: :::|||.||:|:.||.|..|:..:  ||.|..||:.|||||::|||:|.|:|.|:|:
Mouse   155 LALSAHENVVVVTIQYRLGIWGFFSTGDEHSR--GNWGHLDQVAALRWVQDNIANFGGNPGSVTI 217

  Fly   216 FGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRKWPQRLGKELG----------- 269
            |||||||.|..:|:.:..|:.||||||.:||.:|.|.....|.|....|...|.
Mouse   218 FGESAGGFSVSVLVLSPLAKNLFHRAISESGVSLTAALITTDVKPIAGLVATLSGCKTTTSAVMV 282

  Fly   270 YAGNLESEKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEILAFAPVIEPYVGDDCVIPKSQQEQ 334
            :....::|.||||...::...||....|      .:..|..|       |.|.|..|:||:.:|.
Mouse   283 HCLRQKTEDELLETSLKLNLFKLDLLGN------PKESYPFL-------PTVIDGVVLPKAPEEI 334

  Fly   335 LSSAWGNSIPMIIGGTSFEGLFSYRTTLDDPLYMLSAFEAIIPKQVRDAIDKE----ELAE-MVR 394
            |:....:::|.|:|....|..:...|.:..||    |...:..|.....:.|.    :::| |:.
Mouse   335 LAEKSFSTVPYIVGINKQEFGWIIPTLMGYPL----AEGKLDQKTANSLLWKSYPTLKISENMIP 395

  Fly   395 RLKKSYFDDPDRASMELYECLHILSIKNFWHD--------IHRTLLARLAYATNLPTYLYRFDMD 451
            .:.:.|....|..:.:          |:.:.|        :...:::|........||:|.|:..
Mouse   396 VVAEKYLGGTDDLTKK----------KDLFQDLMADVVFGVPSVIVSRSHRDAGASTYMYEFEYR 450

  Fly   452 SPHFNHYRILKCGKKVRGVCHADDISYMFYGILSSKL--DKNSPEYRTIERLV-GMWTSFATTGD 513
            ....:..|    .|.|.| .|.|:|    :.:..|..  |..|.|...:.::| ..|.:||..|:
Mouse   451 PSFVSAMR----PKAVIG-DHGDEI----FSVFGSPFLKDGASEEETNLSKMVMKFWANFARNGN 506

  Fly   514 PNCEIIAPVKWDPLRPGGV---------ENCLNIADGLEFIPLPESKQFVVWDSFYTRES 564
            ||             .||:         |..|.|....:.....:.|:...|.....:||
Mouse   507 PN-------------GGGLPHWPEYDQKEGYLKIGASTQAAQRLKDKEVSFWAELRAKES 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	165/548 (30%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	52/106 (49%)
Ces1d	NP_444430.2	COesterase	24..545	CDD:278561	169/570 (30%)
		Aes	<121..>239	CDD:223730	57/121 (47%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832634
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650