DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gas and Ces2a

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_598721.1	Gene:	Ces2a / 102022	MGIID:	2142491	Length:	558	Species:	Mus musculus

Alignment Length:	525	Identity:	168/525 - (32%)
Similarity:	231/525 - (44%)	Gaps:	102/525 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCT----------- 90
            |..||::|............::|.|||||:||||.|||..|:.|..|.||||.|
Mouse    36 THRGQVRGSFVHVKDTKSGVHAFLGIPFAKPPVGLLRFAPPEDPEPWSGVRDGTSQPAMCLQPDI 100

  Fly    91 YAREKPMQRNSITNAAEGSEDCLYLNVYA-KRLESPKPLPVMVWIFGGGFQVGGAS----RELYG 150
            ...|...:.|.|......||||||||:|. ...:....|||||||.|||..||.||    .:|..
Mouse   101 MNLEDAKEMNLILPPISMSEDCLYLNIYTPTHAQEGSNLPVMVWIHGGGLVVGSASMNDVSKLAA 165

  Fly   151 PDYFMKHDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITV 215
            .:     :|::|.|.||:|||||.|..|:..:  ||.|..||:.|||||::|||.|.|:.:.:|:
Mouse   166 TE-----EIVIVAIQYRLGVLGFFSTGDQHAR--GNWGYLDQVAALRWVQKNIAYFGGNRDRVTI 223

  Fly   216 FGESAGG--ASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRKWPQRLGKELGYAGNLESEK 278
            ||.||||  .|:|||  :..::||||.||:|||.||.     ||
Mouse   224 FGVSAGGTSVSSHIL--SPMSKGLFHGAIMQSGVALL-----PD--------------------- 260

  Fly   279 ELLEFFQQIPASKLAQYCNSIVTQEE--------QRDYEILAFAPVIE--PYVGDDCVIPKSQQE 333
             |:....::....:|.......|..|        :...||||...|.:  |.|.|...:||..||
Mouse   261 -LISDTSEVVYKTVANLSGCEATDSEALIHCLRAKSKQEILAINQVFKMIPAVVDGEFLPKHPQE 324

  Fly   334 QLSSAWGNSIPMIIGGTSFE---GLFSYRTTLDDPLYMLSAFEAIIPKQVRD---AIDKEELAEM 392
            .|:|...:.:|.|||..:.|   |:         |::|  ..:.||....|:   |:.|...|.|
Mouse   325 LLTSMDFHPVPSIIGVNTDECGWGV---------PMFM--GLDHIIKNITRETLPAVLKNTAARM 378

  Fly   393 V------RRLKKSYF---DDPDRASMELYECLHILSIKNFWHDIHRTLLARLAYATNLPTYLYRF 448
            :      ..|.:.|.   :||:....:..|.|     .:|...|....:|.. ..:..|.|.|.|
Mouse   379 MLPPECSHLLVEEYMGDTEDPETLQAQFREML-----GDFMFVIPALQVAHF-QRSQAPVYFYEF 437

  Fly   449 DMDSPHFNHYRILKCGKKVRGVCHADDISYMFYGIL-SSKLDKNSPEYRTIERLVGMWTSFATTG 512
            ...|....|.|    ...|: ..|.||::::|...| ...||....|......::..|.:||..|
Mouse   438 QHLSSFIKHVR----PSHVK-ADHGDDVAFVFGSYLWDMNLDLTEEEELLKRMMMKYWANFARNG 497

  Fly   513 DPNCE 517
            :||.|
Mouse   498 NPNSE 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	168/525 (32%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	48/109 (44%)
Ces2a	NP_598721.1	COesterase	30..537	CDD:278561	168/525 (32%)
Ces2a	NP_598721.1	Aes	<127..>230	CDD:223730	48/109 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832749
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640