DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gas and Ces2

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001258232.1	Gene:	Ces2 / 100910144	RGDID:	6504334	Length:	561	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	174/573 - (30%)
Similarity:	256/573 - (44%)	Gaps:	137/573 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCTYAREKPMQR-- 99
            |..||::|:...........::|.|||||:||||.|||..|:||..|.||||.|......:|.
  Rat    38 THTGQVQGKLDHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEPPEPWSGVRDATSQPAMCLQNLD 102

  Fly   100 ----------NSITNAAEGSEDCLYLNVYA-KRLESPKPLPVMVWIFGGGFQVGGASRELY-GPD 152
                      ..|.::...||||||||||| ........|||||||.||...||.||  :| |..
  Rat   103 ILDEVGLLDMKMILSSISMSEDCLYLNVYAPAHAREGSNLPVMVWIHGGALVVGMAS--MYDGSL 165

  Fly   153 YFMKHDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFG 217
            ..:..|:::|||.||:|||||.|..|:..:  ||.|..||:.|||||::|||.|.|:|..:|:||
  Rat   166 LTVNEDLVVVTIQYRLGVLGFFSTGDEHAR--GNWGYLDQVAALRWVQQNIAHFGGNPNRVTIFG 228

  Fly   218 ESAGG--ASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRKWPQRLGKELGYAGNLESEKEL 280
            |||||  .|:|::  :..::||||.||::||.||.     ||                      |
  Rat   229 ESAGGTSVSSHVI--SPMSQGLFHGAIMESGVALL-----PD----------------------L 264

  Fly   281 LEFFQQIPASKLAQY--CNSIVTQ------EEQRDYEILAFAPVIE--PYVGDDCVIPKSQQEQL 335
            :....:..::.:|:.  |.::.::      ..:...|||....|.:  |.|.|...:|:..:|.|
  Rat   265 ISETSETVSTTVAKLSGCEAMDSEALVRCLRAKSGAEILVINKVFKMIPAVVDGEFLPRHPKELL 329

  Fly   336 SSAWGNSIPMIIGGTSFEGLFSYRTTLDDPLYMLSAFEAIIPKQVRD---AIDKEELAEMV---- 393
            :|...:.:|.|||..:.|    |..|:  |:.|.:|  .||.:..|:   |:.|:..|:|:
  Rat   330 ASEDFHPVPSIIGVNTDE----YCCTI--PMVMGTA--QIIKELSRENLQAVLKDTAAQMMLPPE 386

  Fly   394 --RRLKKSYF---DDPDRASMELYE-------CLHILSIKNFWHDIHRTLLARLAYATNLPTYLY 446
              ..|.:.|.   ||.....::..|       .:..|.:.:|             ..::.|.|.|
  Rat   387 CGDLLMEEYMGNTDDSQTLQIQYTEMMGDFLFVIPALQVAHF-------------QRSHAPVYFY 438

  Fly   447 RFDMDSPHFNHYRILKCGKKVR----GVCHADDISYMFYGILSS-KLDKNSPEYRTIERLVGMWT 506
            .|.....:|         |.||    ...|||::.::|....|. |||....|.....|::..|.
  Rat   439 EFQHAPSYF---------KNVRPPHVKADHADEVPFVFGSFFSGMKLDFTEEERLLSRRMMKYWA 494

  Fly   507 SFATTGDPNCEIIAPVKWDPLRPGGVENCLNIADGLEFIP-LPESKQFVVWDS 558
            :||..|:||.|                       ||.:.| |...:|::..|:
  Rat   495 NFARQGNPNSE-----------------------GLPYWPALDHDEQYLQLDT 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	168/546 (31%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	53/106 (50%)
Ces2	NP_001258232.1	COesterase	31..540	CDD:278561	174/573 (30%)
Ces2	NP_001258232.1	Aes	<130..>233	CDD:223730	53/106 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336353
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830