DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gas and Ces1f

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001096829.2	Gene:	Ces1f / 100125372	RGDID:	1642419	Length:	561	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	154/519 - (29%)
Similarity:	239/519 - (46%)	Gaps:	87/519 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRD-------CTYAREK 95
            ||..|:|..:....       |.|:|||:||:|.|||..|||...|..|::       |:....|
  Rat    36 KYVSLEGVTQSVAV-------FLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTTYPPMCSQDAAK 93

  Fly    96 PMQRNS-ITNAAEG-----SEDCLYLNVYAKR-LESPKPLPVMVWIFGGGFQVGGASRELY-GPD 152
            ..:.|. :||..|.     ||||||||:|... ......|||||||.|||..:||||  .| |..
  Rat    94 GQRMNDLLTNRKEKIHLEFSEDCLYLNIYTPADFTKNSRLPVMVWIHGGGMTLGGAS--TYDGRV 156

  Fly   153 YFMKHDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFG 217
            .....::::|.|.||:|:.||.|..|:..:  ||.|..||:.||.||::|||:|.|||.|:|:||
  Rat   157 LSAYENVVVVAIQYRLGIWGFFSTGDEHSR--GNWGHLDQVAALHWVQDNIANFGGDPGSVTIFG 219

  Fly   218 ESAGGASTHILMQTEQARGLFHRAIVQSGSA-LCAWATQPDRKWPQRLGKELG----------YA 271
            |||||.|..:|:.:...:.||||||.:||.. |....|:..|...:::....|          :.
  Rat   220 ESAGGFSVSVLVLSPLTKNLFHRAISESGVVFLPGLLTKDVRPAAKQIADMAGCETTTSAIIVHC 284

  Fly   272 GNLESEKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEILAFAPVIEPYVGDDCVIPKSQQEQLS 336
            ...::|:||||..:::...||:.      .::.:..|..|:       .|.|:.|:||..:|.|:
  Rat   285 LRQKTEEELLEIMKKMNLIKLSS------QRDNKESYHFLS-------TVVDNVVLPKDPKEILA 336

  Fly   337 SAWGNSIPMIIGGTSFE-GLFSYRTTLDDPLYMLSAFEAIIPKQVRDAIDKEELAEMVRRLKKSY 400
            ....|::|.|:|....| |            ::|......:|..|.  :||:....::.:....|
  Rat   337 EKNFNTVPYIVGINKQECG------------WLLPTMMGFVPADVE--LDKKMAITLLEKFASLY 387

  Fly   401 F--DDPDRASMELYECLHILSIK----------NFWHDIHRTLLARLAYATNLPTYLYRFDMDSP 453
            .  :|....::|.|......|||          :....|...:::|.......|||:|
  Rat   388 GIPEDIIPVAIEKYRKGSDDSIKIRDGILAFIGDVSFSIPSVMVSRDHRDAGAPTYMY------- 445

  Fly   454 HFNHYRILKCGKKVRGVC--HADDISYMFYGILSSKLDKNSPEYRTIERLVGMWTSFATTGDPN 515
            .:.:|......::.:.|.  ||||: |..:|....:...:..|.:..:.::..|.:||..|:||
  Rat   446 EYQYYPSFSSPQRPKHVVGDHADDL-YSVFGAPILRDGASEEEIKLSKMVMKFWANFARNGNPN 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	154/519 (30%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	49/106 (46%)
Ces1f	NP_001096829.2	COesterase	24..545	CDD:278561	154/519 (30%)
		Aes	<121..>234	CDD:223730	53/116 (46%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336513
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm44890
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.650