Protein Alignment CG4610 and MTO1

DIOPT Version :10

• Sequence 1: NP_611677.1
• Gene: CG4610 / 37571
• FlyBaseID: FBgn0034735
• Length: 661
• Species: Drosophila melanogaster
• Sequence 2: NP_001116698.1
• Gene: MTO1 / 25821
• HGNCID: 19261
• Length: 732
• Species: Homo sapiens
• Alignment Length: 688
• Identity: 364/688 - (52%)
• Similarity: 479/688 - (69%)
• Gaps: 60/688 - (8%)

  Fly    18 APSRSAHSAGADIYDVVVIGGGHAGTEASAAAARMGSRTLLLTHKLETIGEMSCNPSFGGIGKGH 82
            |..|:.|      :||:|||||||||||:.||||.|||||||||:::|||:||||||||||||||
Human    30 AAPRTPH------FDVIVIGGGHAGTEAATAAARCGSRTLLLTHRVDTIGQMSCNPSFGGIGKGH 88

  Fly    83 LMREVDALDGVCARCCDVSGVHYKVLNRRRGPAVWGPRAQIDRQLYKKAVQQELHSTPNLEIRAA 147
            ||||||||||:|:|.||.|||||||||||:||||||.||||||:|||:.:|:|:.:||.|.::..
Human    89 LMREVDALDGLCSRICDQSGVHYKVLNRRKGPAVWGLRAQIDRKLYKQNMQKEILNTPLLTVQEG 153

  Fly   148 AVDNLLIEDEQDTQARRC--TGVLLANGEVVRSRSVVLTTGTFLRAHINIGLEVRPAGRIGDAPA 210
            ||::|::.:.:.....:|  :||:|.:|..|.:.||:||||||||..|.||||..||||:||.|:
Human   154 AVEDLILTEPEPEHTGKCRVSGVVLVDGSTVYAESVILTTGTFLRGMIVIGLETHPAGRLGDQPS 218

  Fly   211 KALGEAIDRLGFRMGRLKTGTPPRIAKDSVDFSQLQRHEGDDPPMPFSFLNKDVWLPAKDQLPCY 275
            ..|.:.:::|||.:|||||||||||||:|::||.|.:|..|:|.:||||.|:.||:..:||||||
Human   219 IGLAQTLEKLGFVVGRLKTGTPPRIAKESINFSILNKHIPDNPSIPFSFTNETVWIKPEDQLPCY 283

  Fly   276 LTYTTPKVSDIVRDNLHVNRHVTEEITGPRYCPSIESKILRFGAKVHQVWLEPEGLDSSLVYPQG 340
            ||:|.|:|.:||..|||:|.||.|...|||||||||||:|||..::|||||||||:||.|:||||
Human   284 LTHTNPRVDEIVLKNLHLNSHVKETTRGPRYCPSIESKVLRFPNRLHQVWLEPEGMDSDLIYPQG 348

  Fly   341 ISCTLPHDQQVELVHAIQGLEKAVVVQPGYGVEYDFIDPRELYPTLETKRVPGLFFAGQINGTTG 405
            :|.|||.:.|.:::..|:|||||.|:||||||:||::|||::.|:|||..|..||||||||||||
Human   349 LSMTLPAELQEKMITCIRGLEKAKVIQPGYGVQYDYLDPRQITPSLETHLVQRLFFAGQINGTTG 413

  Fly   406 YEEAAA----------------------------------------QGIIAGANAAGKTRHSDGR 430
            ||||||                                        ||:|||.||:  .|.|...
Human   414 YEEAAAQTECCSVARLECSDMISQLQAILLPQPSLVAGTAGMHHNTQGVIAGINAS--LRVSRKP 476

  Fly   431 QLTISRTEGYIGVLIDDLTSLGTNEPYRMFTSRAEFRLSLRPDNADMRLTQKGY-EFGLVSSDRY 494
            ...:|||||||||||||||:|||:|||||||||.||||||||||||.|||.:|| :.|.||..||
Human   477 PFVVSRTEGYIGVLIDDLTTLGTSEPYRMFTSRVEFRLSLRPDNADSRLTLRGYKDAGCVSQQRY 541

  Fly   495 QHFQQTEARLQSAIESLRRLRKHTHYWRQALNLPKAKASVEKS----AFDMLGIPADNITIEQLI 555
            :.....::.|:..|..|:.:...:..|::.  :|:|..|..:|    |.|:|  ..:.:.::.|.
Human   542 ERACWMKSSLEEGISVLKSIEFLSSKWKKL--IPEASISTSRSLPVRALDVL--KYEEVDMDSLA 602

  Fly   556 HLHPNELSWLKGERNLAERLKIEALYSFFVDEQQRDVEDVRREERLSIPADIDYFS-KSLSLSNE 619
            ...|..|......|.|||||||||.|...:..|.::::.|:::|.|.:|.|:||.: :.:|||:|
Human   603 KAVPEPLKKYTKCRELAERLKIEATYESVLFHQLQEIKGVQQDEALQLPKDLDYLTIRDVSLSHE 667

  Fly   620 ERQKLTLIQPQTIAAASRIQGVTPSTIVRILKYVKKAE 657
            .|:||...:||||.|||||.||||:.|:.:|::||..:
Human   668 VREKLHFSRPQTIGAASRIPGVTPAAIINLLRFVKTTQ 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4610	NP_611677.1	MnmG	28..661	CDD:440214	361/678 (53%)
MTO1	NP_001116698.1	MnmG	36..710	CDD:440214	362/682 (53%)