Protein Alignment CG4554 and UTP20

DIOPT Version :9

• Sequence 1: NP_611676.1
• Gene: CG4554 / 37570
• FlyBaseID: FBgn0034734
• Length: 2733
• Species: Drosophila melanogaster
• Sequence 2: NP_009551.2
• Gene: UTP20 / 852282
• SGDID: S000000100
• Length: 2493
• Species: Saccharomyces cerevisiae
• Alignment Length: 2919
• Identity: 645/2919 - (22%)
• Similarity: 1154/2919 - (39%)
• Gaps: 622/2919 - (21%)

  Fly     1 MASLAEKTKDTNTFRFKSFGDRVNEIDL---RHLALYHIGHRNEELDEEENATYFQQTIQKWNVL 62
            ||...:.||.:..:|:.||..|::::.:   |:|        .:.:.:...:::|..:..:|..:
Yeast     1 MAKQRQTTKSSKRYRYSSFKARIDDLKIEPARNL--------EKRVHDYVESSHFLASFDQWKEI 57

  Fly    63 NLSEEYNYFSKRC-RKIVTLPQLLHQKDFVVDLLLERLSTATNLSQQPLLELLYVLAKDLREEFY 126
            |||.::..|:... ..:.||||:|:....:.:.|:..::.....|.||||:||.....||..:|.
Yeast    58 NLSAKFTEFAAEIEHDVQTLPQILYHDKKIFNSLVSFINFHDEFSLQPLLDLLAQFCHDLGPDFL 122

  Fly   127 PYFQRVLDRLICLLNT----QDSEQLEWTLICLAHLFKTLKPYLKRNIGVVFNAILPLLDEQHYA 187
            .:::..:..||.||:.    :.|...||...|||::||.|..:|.:.:.:..:.::|||  .|..
Yeast   123 KFYEEAIKTLINLLDAAIEFESSNVFEWGFNCLAYIFKYLSKFLVKKLVLTCDLLIPLL--SHSK 185

  Fly   188 EHVTNFAVECFAYIAR-----DVRDFPRFLTYVLKTVLREQVESVHGCGRLIYEILRGVNGQLHN 247
            |:::.|:.|..:::.|     ::|:|.|.:...|:.. .||.....|...|..|.:......||:
Yeast   186 EYLSRFSAEALSFLVRKCPVSNLREFVRSVFEKLEGD-DEQTNLYEGLLILFTESMTSTQETLHS 249

  Fly   248 SAAEIFAHVLEVLVNKDSAHTKDQTELLGDIVEYSLGLLLNFLRSDQSNILWQKLCSAASSESVD 312
            .|..|.:.:|...:.|.|.             |.|:.||     ||    :|..:...||.||
Yeast   250 KAKAIMSVLLHEALTKSSP-------------ERSVSLL-----SD----IWMNISKYASIES-- 290

  Fly   313 EQRVIDLMLPL--VTHKDGRYVSELPLV-VGTLLKLL--------DRELDPLQPLTTLVTSLLKA 366
                   :||:  |.::|  :...|... :..:||:|        .|::.....:|.|:..::..
Yeast   291 -------LLPVYEVMYQD--FNDSLDATNIDRILKVLTTIVFSESGRKIPDWNKITILIERIMSQ 346

  Fly   367 QH--TQLSQLDASRLLQKLLSISR-KQVTVYEDAILQLLDYSQFEILVLPNVIGYFEEQRQLRAR 428
            ..  ..|||...:.|....:..|. |.:|::..   :|.:|:      |.|:...|.|..|...|
Yeast   347 SENCASLSQDKVAFLFALFIRNSDVKTLTLFHQ---KLFNYA------LTNISDCFLEFFQFALR 402

  Fly   429 ELLARI----------VLHKRPLKVDGNSLAQWVAYPLQLKQKDTIKLV------EQELLHL--- 474
            ....|:          :..|:..:..|..:|   .:.|::..|..::.|      |:.:|.:
Yeast   403 LSYERVFSFNGLKFLQLFLKKNWQSQGKKIA---LFFLEVDDKPELQKVREVNFPEEFILSIRDF 464

  Fly   475 ----DLTKEEHLLLI----------------ILVPHLR----------GFNKQPL---------- 499
                ::.....|..|                |::|.|.          .|.|..:
Yeast   465 FVTAEINDSNDLFEIYWRAIIFKYSKLQNTEIIIPLLERIFSTFASPDNFTKDMVGTLLKIYRKE 529

  Fly   500 EQGLQSVIEKLICDNGKDFTQLLLLLQTHALLKFNL--PKSLRSSLNGYLIPELGKDIRALACLQ 562
            :....:.:.|.|.||.:::.:.|..|:....|..||  .:||:..::.|
Yeast   530 DDASGNNLLKTILDNYENYKESLNFLRGWNKLVSNLHPSESLKGLMSHY---------------- 578

  Fly   563 VVLLQGPKNELSTSDELLFGIGGLLSQPVSLYRRIAAHCLDVLNSSSKPNPYSHFNAAACIEPTV 627
                  |...||.:|..:...|.:..:.:.|.:     .|.:|.....|:..|.......|..|:
Yeast   579 ------PSLLLSLTDNFMLPDGKIRYETLELMK-----TLMILQGMQVPDLLSSCMVIEEIPLTL 632

  Fly   628 HNYRELLLQLQQLEPASAQFKQFSQLPHFKEHAVSLLLGLLYNNFKFVWAPVQQLLAAYVKTMTV 692
            .|.|:|.::::.:   .|:|.:...........:..|.|||...|..||..|...|.   ...|.
Yeast   633 QNARDLTIRIKNV---GAEFGKTKTDKLVSSFFLKYLFGLLTVRFSPVWTGVFDTLP---NVYTK 691

  Fly   693 DE--FWTLFKA--KLVDTVACIDY---------KKEVTTLQVPYQRD-----------YQSAALT 733
            ||  .|.|..:  ||.|....:||         .|.:....|...||           |.:...:
Yeast   692 DEALVWKLVLSFIKLPDENQNLDYYQPLLEDGANKVLWDSSVVRLRDTIDTFSHIWSKYSTQNTS 756

  Fly   734 MLLTLPGEQQLTLQQALNYRQLL--WQSVPKLGTLAEVKNADLVRLFLQFVDNEYRAQLEKSEHT 796
            ::.|....:..|....|...|.|  ..|:|:   :||....|:.    .||.|:::...:
Yeast   757 IISTTIERRGNTTYPILIRNQALKVMLSIPQ---VAENHFVDIA----PFVYNDFKTYKD----- 809

  Fly   797 WNVNEATAADIDVEEDDENENNETKPEPRGRQKRRTQNAHTKFILQTLQLKLACFVSQPNPKALH 861
                         |||.|||...|     |......:|.    .|:||.       ...|.|.::
Yeast   810 -------------EEDMENERVIT-----GSWTEVDRNV----FLKTLS-------KFKNIKNVY 845

  Fly   862 RQAEMHDFYLELLAGPNSQLQQLALDCLAAYKQPAALVQQKAQLSGLIDEEKFKTTLSGF----E 922
            ...|:||..:.||...|:.:|:||||.|.|||.| .|.:.:..|..|:|:..||..::.|    .
Yeast   846 SATELHDHLMVLLGSRNTDVQKLALDALLAYKNP-TLNKYRDNLKNLLDDTLFKDEITTFLTENG 909

  Fly   923 LSSITAQQRSELIPFMLRVLYGKML---TKGVQKQLSAQLRKTLILRFLGQLEESEIMDFLQMAF 984
            ..||.|:....::|::||:.:|:..   |.|.::.     ||..::..|...::..|.|||.:|.
Yeast   910 SQSIKAEDEKVVMPYVLRIFFGRAQVPPTSGQKRS-----RKIAVISVLPNFKKPYINDFLSLAS 969

  Fly   985 GRFSAYTDKPVDEVAKYARESYDPSAVIAAKQLQRIVNLLELIRKEFAGKLTSDFQCY---VLKL 1046
            .|        :|....:.......|:....|.::|:...:.::....: .|.::|..:   ||:.
Yeast   970 ER--------LDYNYFFGNSHQINSSKATLKTIRRMTGFVNIVNSTLS-VLRTNFPLHTNSVLQP 1025

  Fly  1047 LLLVGSVAQEVINGEG----KLVAAYKNVKHSGLQTLVNYF---GQLVDMEELWQEPQMNAICEV 1104
            |:...::|..|::.|.    .|.....|::..||:.|.:.|   |...|    | ...|..|..|
Yeast  1026 LIYSIAMAYYVLDTESTEEVHLRKMASNLRQQGLKCLSSVFEFVGNTFD----W-STSMEDIYAV 1085

  Fly  1105 YLWPGIARLSQDSIHTPTPMLKLLLLWGGEPRFQKWLKKSAPADKLPIMHHLMALLLNEKAKPNV 1169
            .:.|.|:..|.:::..|:.:|:|.|.|...|...::|.    .|:......||..:.|:..|..|
Yeast  1086 VVKPRISHFSDENLQQPSSLLRLFLYWAHNPSLYQFLY----YDEFATATALMDTISNQHVKEAV 1146

  Fly  1170 KRAILQVVEHLLESAATEEYGAEALSIVHPHIPTILQQLQNSWRHKKAGRQTLDKRELNILTLIT 1234
            ...|::..:.::.:...:::..:.::::......||..|     :.|..........||:|..||
Yeast  1147 IGPIIEAADSIIRNPVNDDHYVDLVTLICTSCLKILPSL-----YVKLSDSNSISTFLNLLVSIT 1206

  Fly  1235 -------SHV-------------------EEPDTCELLLQVLLPIFTKQSASAAPETVVQLVTTL 1273
                   .||                   :|.||.::|..:.|.:|   :.:.:...:.:|.||:
Yeast  1207 EMGFIQDDHVRSRLISSLISILKGKLKKLQENDTQKILKILKLIVF---NYNCSWSDIEELYTTI 1268

  Fly  1274 GNLLKRVSKPQNYLRQLAPLFEQVSALPARKLLCDLLADMAKQLHKEAKQNPDISPIAASLREWV 1338
            .:|.|...:     |.|            |..|.:|..::.:::       |::..|:
Yeast  1269 SSLFKTFDE-----RNL------------RVSLTELFIELGRKV-------PELESIS------- 1302

  Fly  1339 RIVLLLNAWDKRWLEQPDYDKRLEALSELKQLAEKKDKKIDLQLGVLVVYNCFYMLRNDSDLGMR 1403
            ::|..||::....:.:.|:.:   .||..|.|.|...|.......:.:::...:.:.|..:|.:|
Yeast  1303 KLVADLNSYSSSRMHEYDFPR---ILSTFKGLIEDGYKSYSELEWLPLLFTFLHFINNKEELALR 1364

  Fly  1404 VNIGELLKPLLPLITLQLEVKEDLH--FWLEDTVLPLLQRCMRDEKHEHARSEAIGLLGELARQC 1466
            .|....:...:..|..:..:.|...  ..|:|.:||.::..:||.. |..:||.:.:|..:.:..
Yeast  1365 TNASHAIMKFIDFINEKPNLNEASKSISMLKDILLPNIRIGLRDSL-EEVQSEYVSVLSYMVKNT 1428

  Fly  1467 PAAHEILKDLSPLTDKYDLEVDFFENMLHLQTQRHGRALQRLVNISGGSWRTVPPCARTLTQFLL 1531
            ....: .:|::.|....|.|.|||.|:.|:|..|..||::||    |.....:..  .:::.:|:
Yeast  1429 KYFTD-FEDMAILLYNGDEEADFFTNVNHIQLHRRQRAIKRL----GEHAHQLKD--NSISHYLI 1486

  Fly  1532 PLATRYLMSE----RHSGKHTLVDAAIEAVGVMSEFLPWTQYQAVLRYYLQKLRHVHSQQKQCVR 1592
            |:...|:.|:    |:.|..|.:     |:|.:::.:.|.||:|:||.|:..|:...:|.||.|:
Yeast  1487 PMIEHYVFSDDERYRNIGNETQI-----AIGGLAQHMSWNQYKALLRRYISMLKTKPNQMKQAVQ 1546

  Fly  1593 VVVRILDAFHFDLTQAQTDLVSLAKLKEKLIEAVEAKEPAEESDEVKAEEDAEADEVPVKKEDDQ 1657
            ::|                     :|...|.|.:.......||....::..:..||        .
Yeast  1547 LIV---------------------QLSVPLRETLRIVRDGAESKLTLSKFPSNLDE--------P 1582

  Fly  1658 SDFIDFEEEDPNEPVVEQQRTQLLAPNAAKKVMATITTVLLPTLNRSITEKTNYDTKHKVNRRRL 1722
            |:||..|                                |.|||::.                 |
Yeast  1583 SNFIKQE--------------------------------LYPTLSKI-----------------L 1598

  Fly  1723 SYEREEEEIQRVPIALAMVKLLQKLPLELLENSLPGIFMKVCTFLRSPLKSVRMLTRDILKKIMI 1787
            ....:|..|:|:|||.|:|.::..|..:.:.|.||.|...:|..|||..:.:|...|..|.||.|
Yeast  1599 GTRDDETIIERMPIAEALVNIVLGLTNDDITNFLPSILTNICQVLRSKSEELRDAVRVTLGKISI 1663

  Fly  1788 TLGGSYLGMLLEQLQSLLTRGFQVHVLSVTLHGVLDALKSDLKPEHIENCLQNLLEVALNDIFGD 1852
            .||..||..::::|.:.|.||.|:||||.|:|.:|.::...||...::.....::::.:.:|||.
Yeast  1664 ILGAEYLVFVIKELMATLKRGSQIHVLSYTVHYILKSMHGVLKHSDLDTSSSMIVKIIMENIFGF 1728

  Fly  1853 VNAEKEVEKIVAHTPEAKPSAKSYLTLNIAARHIRDNCLLDLLLPFKEHLARSHSRKVTQKIQEC 1917
            ...||:.|.......|.| |.|||....|.|.:|.......||.|.|..|....:.:...|:.|.
Yeast  1729 AGEEKDSENYHTKVKEIK-SNKSYDAGEILASNISLTEFGTLLSPVKALLMVRINLRNQNKLSEL 1792

  Fly  1918 FAKIVGGLVENTHIARESLLIFIYGTMSE---SISDLLPGTK-KRQLTEKEQALMKRTRPDCLIL 1978
            ..:.:.||..|:....||:|.|.:....|   |.|..:|..| |.|:.|||...:.
Yeast  1793 LRRYLLGLNHNSDSESESILKFCHQLFQESEMSNSPQIPKKKVKDQVDEKEDFFLV--------- 1848

  Fly  1979 QPAPGRRSVATGNKQVKSNAQANAHILVEFGLELLHFVLKRKK--LTDLDYQPFLHPLLPLLKDS 2041
                   ::.:.:..:.||:......|.:|.|:||..|:.|.:  ||....:.|    :|.|:||
Yeast  1849 -------NLESKSYTINSNSLLLNSTLQKFALDLLRNVITRHRSFLTVSHLEGF----IPFLRDS 1902

  Fly  2042 LSSNHARTTTYALKCYTAIWLGEYELSDLNREALQPVVARMFQILKNFSTFGATRQEENAQLVRA 2106
            |.|.:.......|:  ..|.|...:.||.:.|..:....::..|:|       .....:::|.:.
Yeast  1903 LLSENEGVVISTLR--ILITLIRLDFSDESSEIFKNCARKVLNIIK-------VSPSTSSELCQM 1958

  Fly  2107 SFKAVVALLRKCEDYQLSNEQIEQLLLHIEQELQEGECSSQTMVFTLLKALVGRKVDSRSLHDLM 2171
            ..|.:.|.:|. .|..|.:..:..:|..:..:|.|.  |.|.:.|..|||||.:.:....|:|:.
Yeast  1959 GLKFLSAFIRH-TDSTLKDTALSYVLGRVLPDLNEP--SRQGLAFNFLKALVSKHIMLPELYDIA 2020

  Fly  2172 KRLGDLSIISSSDYVRDECRGILLTYIMEY-TLRQKVEQIVKFMSVQLCYSQTAGRQSAIQFMHS 2235
            ....::.:.:.|..:||..|.:...::||| ..:.::|:..|||...|.|...:||||.::.::.
Yeast  2021 DTTREIMVTNHSKEIRDVSRSVYYQFLMEYDQSKGRLEKQFKFMVDNLQYPTESGRQSVMELINL 2085

  Fly  2236 IINKFPQLMLVKQSEFLYLSLGTRLVNDEDPSCRRSVAAALEALIGRLTKLERQPLLDLTLLFFT 2300
            ||.|....:|.|.|...:|:|.....||:.|.||...:..:..:   |.|||.:   ||.:
Yeast  2086 IITKANPALLSKLSSSFFLALVNVSFNDDAPRCREMASVLISTM---LPKLENK---DLEI---- 2140

  Fly  2301 APQSSQKPGVREMAAALLSRFVEAEKAGFAERLPLVLPTL-VNVLTLGHAEAGGRFVRAPGYLAA 2364
                     |.:..||.|.   :.:.|.|   |.|.|.|. |.:.::|...            ..
Yeast  2141 ---------VEKYIAAWLK---QVDNASF---LNLGLRTYKVYLKSIGFEH------------TI 2178

  Fly  2365 EVDESELHKKNKRKKFKTLPDEDLLLAGLDNESILEQQQRKADHQLIQLQYCLLKIFEHCGESLL 2429
            |:||..:    ||.::                 ||......::||. .|.|..|..|....|:
Yeast  2179 ELDELAI----KRIRY-----------------ILSDTSVGSEHQW-DLVYSALNTFSSYMEA-- 2219

  Fly  2430 NNPQLSDTV-----DDLAYGSQRLLNHDHNWVRCNAAKLLTHIVAHYDFAYIGQQLSGIKLEAGA 2489
                 :::|     .|:..|....|.:.|:|||.:||.|:..::|:.|...|  .|:.::::..|
Yeast  2220 -----TESVYKHGFKDIWDGIITCLLYPHSWVRQSAANLVHQLIANKDKLEI--SLTNLEIQTIA 2277

  Fly  2490 KKALYFIYAQPAEDIKSLVLDLCAQVTPGETAQEMIDELSKILLFVGHMLRD--VPFSLKQEKND 2552
            .:.|:               .|.|...|...|...|    |.|:.:..:.::  .||.:...|..
Yeast  2278 TRILH---------------QLGAPSIPENLANVSI----KTLVNISILWKEQRTPFIMDVSKQT 2323

  Fly  2553 DEEEREPVNKISLTWLIRNIRFLINKEVAKAPHDISIRTAMFTLIEALSTLLSVESVTRLAPSLL 2617
            .|:.:...   ::.:::..|..:|..:..:....:| :.|...|:..|..:|..:.|......:|
Yeast  2324 GEDLKYTT---AIDYMVTRIGGIIRSDEHRMDSFMS-KKACIQLLALLVQVLDEDEVIAEGEKIL 2384

  Fly  2618 QALV--------REMSEEDQNVDAELRQQALRVGSRLRKRIGAEVYDKLRNAVQTKLMARRAERR 2674
            ..|.        |.:.||.:.: ..|..:.|::   |..::....:.|:..||:..::.||.|||
Yeast  2385 LPLYGYLETYYSRAVDEEQEEL-RTLSNECLKI---LEDKLQVSDFTKIYTAVKQTVLERRKERR 2445

  Fly  2675 KVVAQEKIHDPERAAKRKAGMQERKKAAKRLKAAVVRGKAPDIKQKLKKRKRKAEMDGF 2733
            ...|...::.|:.:|.:|.    ||.|..|                 :|||.:.:.:|:
Yeast  2446 SKRAILAVNAPQISADKKL----RKHARSR-----------------EKRKHEKDENGY 2483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4554	NP_611676.1	DRIM	840..1444	CDD:284870	136/648 (21%)
UTP20	NP_009551.2	DRIM	823..1409	CDD:311475	138/662 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343833
Domainoid	1	1.000	189	1.000	Domainoid score	I649
eggNOG	1	0.900	-	-		E1_KOG1823
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38373
Inparanoid	1	1.050	345	1.000	Inparanoid score	I404
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55432
OrthoFinder	1	1.000	-	-		FOG0003906
OrthoInspector	1	1.000	-	-		oto100390
orthoMCL	1	0.900	-	-		OOG6_103119
Panther	1	1.100	-	-	LDO	PTHR17695
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1618
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.880