DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4554 and UTP20

DIOPT Version :9

Sequence 1:NP_611676.1 Gene:CG4554 / 37570 FlyBaseID:FBgn0034734 Length:2733 Species:Drosophila melanogaster
Sequence 2:NP_055318.2 Gene:UTP20 / 27340 HGNCID:17897 Length:2785 Species:Homo sapiens


Alignment Length:2959 Identity:783/2959 - (26%)
Similarity:1395/2959 - (47%) Gaps:437/2959 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 KDTNTFRFKSFGDRVNEIDLRHLALYHIGHRNEELD--EEENATYFQQTIQKWNVLNLSEEYNYF 71
            |..||:||.:|.:|:..:::      .|.||.:...  |||..|||.:.:.||..|||:|.:..|
Human     9 KTENTYRFLTFAERLGNVNI------DIIHRIDRTASYEEEVETYFFEGLLKWRELNLTEHFGKF 67

  Fly    72 SK----RCRKIVTLPQLLHQKDFVVDLLLERLSTATNLSQQPLLELLYVLAKDLREEFYPYFQRV 132
            .|    :|:   :..||::.::.:|..|...|....:.:.||||:|:..||:||:.:|||:|...
Human    68 YKEVIDKCQ---SFNQLVYHQNEIVQSLKTHLQVKNSFAYQPLLDLVVQLARDLQMDFYPHFPEF 129

  Fly   133 LDRLICLLNTQDSEQLEWTLICLAHLFKTLKPYLKRNIGVVFNAILPLLDEQHYAEHVTNFAVEC 197
            ...:..:|.|||:|.|||....|::|:|.|...:.:::..:::....||  .|...|:.|||.|.
Human   130 FLTITSILETQDTELLEWAFTSLSYLYKYLWRLMVKDMSSIYSMYSTLL--AHKKLHIRNFAAES 192

  Fly   198 FAYIARDVRDFPRFLTYVLKTVLREQVESVHGCGRLIYEILRGVNGQLHNSAAEIFAHVLEVLVN 262
            |.::.|.|.| ...|..::...|.:..|.|.|.|:|::|:.:||....|:...:    .:::::.
Human   193 FTFLMRKVSD-KNALFNLMFLDLDKHPEKVEGVGQLLFEMCKGVRNMFHSCTGQ----AVKLILR 252

  Fly   263 KDSAHTKDQTE----LLGDIVEYSLGLLLNFLRSDQSNILWQ--------------KLCSAASSE 309
            |....|:.:|:    |:|:.::..:...::::..:.....::              |.....|||
Human   253 KLGPVTETETQLPWMLIGETLKNMVKSTVSYISKEHFGTFFECLQESLLDLHTKVTKTNCCESSE 317

  Fly   310 SVDEQRVIDLMLPLVTHKDGRYV---SELPLVVGTLLKLLDRELDPLQPLTTLVTSLLKAQHTQL 371
            .:  :|:::..|.||.|..|..:   :::..|:...|::........:.|..::::|:..::..|
Human   318 QI--KRLLETYLILVKHGSGTKIPTPADVCKVLSQTLQVASLSTSCWETLLDVISALILGENVSL 380

  Fly   372 SQLDASRLLQKLLS--ISRKQVTVYEDAILQLLDYSQFEILVLPNVIGYF-------EEQRQLRA 427
            .:......::|:..  ..::.:..:.:.:..:   .|||.|.||:.:.|.       :...:..|
Human   381 PETLIKETIEKIFESRFEKRLIFSFSEVMFAM---KQFEQLFLPSFLSYIVNCFLIDDAVVKDEA 442

  Fly   428 RELLARIVLHKRPLKVDGNSLAQWVAYPL---------QLKQKDT-IKLVEQELLHLDLTKEEHL 482
            ..:||:::|:|......|:...:  .|||         .:|||.| .|...::...||     ||
Human   443 LAILAKLILNKAAPPTAGSMAIE--KYPLVFSPQMVGFYIKQKKTRSKGRNEQFPVLD-----HL 500

  Fly   483 LLII-------------------LVPHLRGFNKQ---PLEQGLQSVIEKLI--CDNGKDFTQ--L 521
            |.||                   ::||:|...|:   ||..|.   ||.|.  .|.| .|.:  |
Human   501 LSIIKLPPNKDTTYLSQSWAALVVLPHIRPLEKEKVIPLVTGF---IEALFMTVDKG-SFGKGNL 561

  Fly   522 LLLLQ-THALLKFNLPKSLRSSLNGYLIP-ELGKDIRALACLQ--VVLLQGPKNELSTSDELLFG 582
            .:|.| .:.||...     .||...:|:| |..|::.....|:  |:||    .:|......|.|
Human   562 FVLCQAVNTLLSLE-----ESSELLHLVPVERVKNLVLTFPLEPSVLLL----TDLYYQRLALCG 617

  Fly   583 IGGLLSQP--VSLYRRIAAH-----------CLDVLNS--------------SSKPNPYSHFNAA 620
            ..|.|||.  :.|:.::.|:           .:.:||.              |.:.:.::....|
Human   618 CKGPLSQEALMELFPKLQANISTGVSKIRLLTIRILNHFDVQLPESMEDDGLSERQSVFAILRQA 682

  Fly   621 ACIEPTVHNYRELLLQLQQLEPASAQFKQFSQLPH--FKEHAVSLLLGLLYNNFKFVWAPVQQLL 683
            ..:..||::|||.||.|::|.....|    :.:|.  .:|..:..|||:||.||..:|.||.:|:
Human   683 ELVPATVNDYREKLLHLRKLRHDVVQ----TAVPDGPLQEVPLRYLLGMLYINFSALWDPVIELI 743

  Fly   684 AAYVKTMTVDEFWTLFKAKLVDTVACIDYKKEVTTLQVPYQRDY--------------QSAALTM 734
            :::...|...:||.::...|         :|..|..:...|.|.              |...:..
Human   744 SSHAHEMENKQFWKVYYEHL---------EKAATHAEKELQNDMTDEKSVGDESWEQTQEGDVGA 799

  Fly   735 LLTLPGEQQLTL----QQAL---NYRQLLWQSVPKLGTLAEVKNADLVRLFLQFVDNEY---RAQ 789
            |.    .:||.|    |:.|   |:|.|||:::.|.....|.::.:|..|||:|::|||   ..|
Human   800 LY----HEQLALKTDCQERLDHTNFRFLLWRALTKFPERVEPRSRELSPLFLRFINNEYYPADLQ 860

  Fly   790 LEKSEHTWNVNEATAADIDVEE-----DDENENNETKPEPRGRQKRRTQNAHTKFILQTLQLKLA 849
            :..::......:...|: ::||     |||....|..|:....||::|:.|..|.::..||:   
Human   861 VAPTQDLRRKGKGMVAE-EIEEEPAAGDDEELEEEAVPQDESSQKKKTRRAAAKQLIAHLQV--- 921

  Fly   850 CFVSQPNPKALHRQAEMHDFYLELLAGPNSQLQQLALDCLAAYKQPAALVQQKAQLSGLIDEEKF 914
             |....||:||:.::::::.||:||...:..:|::.|||:..||.|..| ..:..|..|:::..|
Human   922 -FSKFSNPRALYLESKLYELYLQLLLHQDQMVQKITLDCIMTYKHPHVL-PYRENLQRLLEDRSF 984

  Fly   915 KTTLSGFELSS----ITAQQRSELIPFMLRVLYGKMLTK---GVQKQLSAQLRKTLILRFLGQLE 972
            |..:..|.:|.    :....|::|.|.::|:|||:|..|   ..|.:.::..|..::||||...:
Human   985 KEEIVHFSISEDNAVVKTAHRADLFPILMRILYGRMKNKTGSKTQGKSASGTRMAIVLRFLAGTQ 1049

  Fly   973 ESEIMDFLQMAFGRFSAYTDKPVDEVAKYARESYDPSAVIAAKQLQRIVNLLELIRKEFAGKLTS 1037
            ..||..||.:.|.....:.:.........|.|..|.|.|:...:...|:|.||::.|..: .|.|
Human  1050 PEEIQIFLDLLFEPVRHFKNGECHSAVIQAVEDLDLSKVLPLGRQHGILNSLEIVLKNIS-HLIS 1113

  Fly  1038 DFQCYVLKLLLLVGSVAQEVINGEGKL----VAAYKNVKHSGLQTLVNYFGQLVDMEEL-WQEPQ 1097
            .:...:|::||.:.:....:::...|:    :...||::..|::.:.:.|   :|.|.. ::..:
Human  1114 AYLPKILQILLCMTATVSHILDQREKIQLRFINPLKNLRRLGIKMVTDIF---LDWESYQFRTEE 1175

  Fly  1098 MNAICEVYLWPGIARLSQDSIHTPTPMLKLLLLWGGEPRFQKWLKKSAPA-DKLPIMHHLMALLL 1161
            ::|:....:||.|:||..:|.::|||:|||:.:|....|:...|.|..|. .:..|:.::.|:|.
Human  1176 IDAVFHGAVWPQISRLGSESQYSPTPLLKLISIWSRNARYFPLLAKQKPGHPECDILTNVFAILS 1240

  Fly  1162 NEKAKPNVKRAILQVVEHLL-----ESAAT---------------EEYGAEALSI----VHPHIP 1202
            .:.........::.:|:.||     |...|               |..| |:::|    :.||:|
Human  1241 AKNLSDATASIVMDIVDDLLNLPDFEPTETVLNLLVTGCVYPGIAENIG-ESITIGGRLILPHVP 1304

  Fly  1203 TILQQLQ----NSWRHKKAGRQTLDKRELNILTLITSHVEEPDTCELLLQVLLPIFTKQSASAAP 1263
            .|||.|.    ::.:.||...:....:||.||:.|:..:::.:...:|:.:|||...:  .:.|.
Human  1305 AILQYLSKTTISAEKVKKKKNRAQVSKELGILSKISKFMKDKEQSSVLITLLLPFLHR--GNIAE 1367

  Fly  1264 ETVVQLVTTLGNLLKRVSKPQNYLRQLAPLFEQVSALPARKLLC---DLLADMAKQLHKEAKQNP 1325
            :|.|.::.|:.||||....|.::|:.:|.||..:....:|||||   :.|:|....|        
Human  1368 DTEVDILVTVQNLLKHCVDPTSFLKPIAKLFSVIKNKLSRKLLCTVFETLSDFESGL-------- 1424

  Fly  1326 DISPIAASLREWVRIVLLLNAWDKRWLEQPDYDKRLEALSELKQLAEKKDKKIDLQLGVLVVYNC 1390
                      :::..|:.|||:|:|.|:..::|.|.|....:.... |:.:.:|:...:.|::||
Human  1425 ----------KYITDVVKLNAFDQRHLDDINFDVRFETFQTITSYI-KEMQIVDVNYLIPVMHNC 1478

  Fly  1391 FYMLRNDSDLGMRVN----IGELLKPLLPLITLQLEVKEDLHFWLEDTVLPLLQRCMRDEKHEHA 1451
            ||.|.. .|:.:..|    :..::|.|..|...:.:.:|.:|    .::|..|::.::.:. |..
Human  1479 FYNLEL-GDMSLSDNASMCLMSIIKKLAALNVTEKDYREIIH----RSLLEKLRKGLKSQT-ESI 1537

  Fly  1452 RSEAIGLLGELARQCPAAHEILKDLSPLTDKYDLEVDFFENMLHLQTQRHGRALQRLVN--ISGG 1514
            :.:...:|..|.:..|...| .|||..||..:|.|:||||||.|:|..|..|||::|..  :.| 
Human  1538 QQDYTTILSCLIQTFPNQLE-FKDLVQLTHYHDPEMDFFENMKHIQIHRRARALKKLAKQLMEG- 1600

  Fly  1515 SWRTVPPCARTLTQFLLPLATRYLMSERHSGKHTLVDAAIEAVGVMSEFLPWTQYQAVLRYYLQK 1579
               .|...:::|..:::|.|...:..|:......:..||.|.:|.:.:.|.|:.|...|::::..
Human  1601 ---KVVLSSKSLQNYIMPYAMTPIFDEKMLKHENITTAATEIIGAICKHLSWSAYMYYLKHFIHV 1662

  Fly  1580 LRHVHSQQKQCVRVVVRILDAFHFDLTQAQTDLVSLAKLKEKLIEAVEAKEP-AEESDEVKAEED 1643
            |:.....||..|.::|.:|:|||||....:..:..:.. :|..|||:|..|| |.|.:.|    |
Human  1663 LQTGQINQKLGVSLLVIVLEAFHFDHKTLEEQMGKIEN-EENAIEAIELPEPEAMELERV----D 1722

  Fly  1644 AEADEVPVKKEDDQS-----DFIDF------EEEDPNEPV--VEQQRTQLLAPNAAKKVMATITT 1695
            .|..|...|...|..     |..|.      |.|...:||  :.|.:.::  ....|.:..|||.
Human  1723 EEEKEYTCKSLSDNGQPGTPDPADSGGTSAKESECITKPVSFLPQNKEEI--ERTIKNIQGTITG 1785

  Fly  1696 VLLPTLNRSITEKTNYDTKHKVNRRRLSYEREEEEIQRVPIALAMVKLLQKLPLELLENSLPGIF 1760
            .:||.|::.:...|..:.:||:.:.::.   .:||:.|||:|.|||||:|.||.|::|.:||.|.
Human  1786 DILPRLHKCLASTTKREEEHKLVKSKVV---NDEEVVRVPLAFAMVKLMQSLPQEVMEANLPSIL 1847

  Fly  1761 MKVCTFLRSPLKSVRMLTRDILKKIMITLGGSYLGMLLEQLQSLLTRGFQVHVLSVTLHGVLDAL 1825
            :|||..|::..:.:|.:.|..|.||:..||..:|..:|::||:.|.||:|||||:.|:|.:|..|
Human  1848 LKVCALLKNRAQEIRDIARSTLAKIIEDLGVHFLLYVLKELQTTLVRGYQVHVLTFTVHMLLQGL 1912

  Fly  1826 KSDLKPEHIENCLQNLLEVALNDIFGDVNAEKEVEKIVAHTPEAKPSAKSYLTLNIAARHIRDNC 1890
            .:.|:...:::||..::|:..:::||.|..||||::|::...||:.| |||.:..|..:.:..:.
Human  1913 TNKLQVGDLDSCLDIMIEIFNHELFGAVAEEKEVKQILSKVMEARRS-KSYDSYEILGKFVGKDQ 1976

  Fly  1891 LLDLLLPFKEHLARSHSRKVTQKIQECFAKIVGGLVENTHIARESLLIFIYGTMSESISDLLPGT 1955
            :..|:||.||.|..:.|.|:.:|:.|...:|..||:.|..:..||:|:..||.:||:    ||  
Human  1977 VTKLILPLKEILQNTTSLKLARKVHETLRRITVGLIVNQEMTAESILLLSYGLISEN----LP-- 2035

  Fly  1956 KKRQLTEKEQ-----ALMKRTRP-DCLILQPAPGRRSVATGNKQVKSNAQANAHILVEFGLELLH 2014
               .|||||:     |...|..| .||:|.|.|    |..|.|.|.|. :.|.||.:|.||.|||
Human  2036 ---LLTEKEKNPVAPAPDPRLPPQSCLLLPPTP----VRGGQKAVVSR-KTNMHIFIESGLRLLH 2092

  Fly  2015 FVLKRKKLTD-----LDYQPFLHPLLPLLKDSLSSNHARTTTYALKCYTAIWLGEYELSDLNREA 2074
            ..||..|:..     |:   .|.|.:.||.|.|.|...:..|.||:|  .||:..:.|..:..:|
Human  2093 LSLKTSKIKSSGECVLE---MLDPFVSLLIDCLGSMDVKVITGALQC--LIWVLRFPLPSIETKA 2152

  Fly  2075 LQPVVARMFQILKNFSTFGATRQEENAQLVRASFKAVVALLRKCEDYQLSNEQIEQLLLHIEQEL 2139
            .| :...:|.:||:::..||.| .:|..||...||.|..|::|.:.||::.:|::.||.:.|:::
Human  2153 EQ-LTKHLFLLLKDYAKLGAAR-GQNFHLVVNCFKCVTILVKKVKSYQITEKQLQVLLAYAEEDI 2215

  Fly  2140 QEGECSSQTMVFTLLKALVGRKVDSRSLHDLMKRLGDLSIISSSDYVRDECRGILLTYIMEYTLR 2204
            .  :.|.|...|.||||::.||:....:.::|:::..|::.:.|:..|.:||.:.|.||::|.|.
Human  2216 Y--DTSRQATAFGLLKAILSRKLLVPEIDEVMRKVSKLAVSAQSEPARVQCRQVFLKYILDYPLG 2278

  Fly  2205 QKVEQIVKFMSVQLCYSQTAGRQSAIQFMHSIINKFPQLMLVKQSEFLYLSLGTRLVNDEDPSCR 2269
            .|:...::||..||.|....||:|.::.:..:.:.|||.:|.:.....::.|....:||:..:|:
Human  2279 DKLRPNLEFMLAQLNYEHETGRESTLEMIAYLFDTFPQGLLHENCGMFFIPLCLMTINDDSATCK 2343

  Fly  2270 RSVAAALEALIGRLTKLERQPLLDLTLLFFTAPQSSQKPGVREMAAALLSRFVEAEKAGFAERLP 2334
            :..:..:::|:|:::..::..|.|:...:|.|    :|...|::||.:...|||:|...|.:||.
Human  2344 KMASMTIKSLLGKISLEKKDWLFDMVTTWFGA----KKRLNRQLAALICGLFVESEGVDFEKRLG 2404

  Fly  2335 LVLPTLVNVLTLGHAEAGGRFVRAPGYLAAEVDESELHKKNKRKKFKTLPDEDLLLAGLDNESIL 2399
            .|||.:                           |.|:..:|    ||.:.:              
Human  2405 TVLPVI---------------------------EKEIDPEN----FKDIME-------------- 2424

  Fly  2400 EQQQRKADHQLIQLQYCLLKIFEHCGESLLNNPQLSDTVDDLAYGSQRLLNHDHNWVRCNAAKLL 2464
            |.:::.||..|......:.|:.:.|.......|  ::|:..:.......|.|.||||...||::.
Human  2425 ETEEKAADRLLFSFLTLITKLIKECNIIQFTKP--AETLSKIWSHVHSHLRHPHNWVWLTAAQIF 2487

  Fly  2465 THIVAHYDFAYIGQQLSGIKLEAGAKK------ALYFIYAQPAEDIKSLVLDLCAQVTPGETAQE 2523
            ..:.|......:.|:.:..|    .||      |:.|:.:...:.:||:.|..|.|:......|.
Human  2488 GLLFASCQPEELIQKWNTKK----TKKHLPEPVAIKFLASDLDQKMKSISLASCHQLHSKFLDQS 2548

  Fly  2524 MIDELSKILLFVGHML-------RDVPFSLKQEKNDDE-----------------EEREPVNK-- 2562
            :.:::.|.|||...:|       .|....:|::..:.|                 ||:|.|.:  
Human  2549 LGEQVVKNLLFAAKVLYLLELYCEDKQSKIKEDLEEQEALEDGVACADEKAESDGEEKEEVKEEL 2613

  Fly  2563 ---ISLTWLIRNIRFLINKEVAKAPHDISIRTAMFTLIEALSTLLSVESVTRLAPSLLQALVREM 2624
               .:|.|||:.:..:...|.|.:|.:...||.:|..:.|::..|.::.|....|.::..|.||:
Human  2614 GRPATLLWLIQKLSRIAKLEAAYSPRNPLKRTCIFKFLGAVAMDLGIDKVKPYLPMIIAPLFREL 2678

  Fly  2625 SEEDQNVDAELRQQALRVGSRLRKRIGAEVYDKLRNAVQTKLMARRAERRKVVAQEKIHDPERAA 2689
            :......|..|:..:..:...|:|.:|.|.:.....:||.:...:||.|:|..|.|.:.:|:.||
Human  2679 NSTYSEQDPLLKNLSQEIIELLKKLVGLESFSLAFASVQKQANEKRALRKKRKALEFVTNPDIAA 2743

  Fly  2690 KRKAGMQERKKAAKRLKAAVVRGKAPDIKQKLKK 2723
            |:|....:.|..||:.|...:|   |..|.|.:|
Human  2744 KKKMKKHKNKSEAKKRKIEFLR---PGYKAKRQK 2774

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4554NP_611676.1 DRIM 840..1444 CDD:284870 163/651 (25%)
UTP20NP_055318.2 HEAT 1 165..202 11/38 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 880..907 9/26 (35%)
DRIM 911..1531 CDD:284870 164/655 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1720..1760 10/43 (23%)
HEAT 2 1841..1878 13/36 (36%)
Nuclear localization signal 2744..2775 11/34 (32%)
Nucleolar localization signal 2744..2761 5/16 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147234
Domainoid 1 1.000 492 1.000 Domainoid score I364
eggNOG 1 0.900 - - E1_KOG1823
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H38373
Inparanoid 1 1.050 877 1.000 Inparanoid score I410
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55432
OrthoDB 1 1.010 - - D22927at33208
OrthoFinder 1 1.000 - - FOG0003906
OrthoInspector 1 1.000 - - oto91833
orthoMCL 1 0.900 - - OOG6_103119
Panther 1 1.100 - - LDO PTHR17695
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1618
SonicParanoid 1 1.000 - - X4920
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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