Protein Alignment KCNH2 and FPK1

DIOPT Version :10

• Sequence 1: XP_047276304.1
• Gene: KCNH2 / 3757
• HGNCID: 6251
• Length: 1185
• Species: Homo sapiens
• Sequence 2: NP_014445.1
• Gene: FPK1 / 855783
• SGDID: S000005330
• Length: 893
• Species: Saccharomyces cerevisiae
• Alignment Length: 221
• Identity: 52/221 - (23%)
• Similarity: 90/221 - (40%)
• Gaps: 42/221 - (19%)

Human   239 DEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCA 303
            ::.|..||....|.|.::.    |..:.||.   ::|..||.|     ..:...||...|..| :
Yeast   379 EQQTTTDNKTRNLSPTKQN----GKATHPRI---KIPLRRAAS-----EPNGLQLASATSPTS-S 430

Human   304 SVRRASSADDIEAMRAG-VLPPP----PRHAS---TGAMHPLRSGLLNSTSDSDLVRYRTISKIP 360
            |.|:.|.:.:|.....| .:|||    |:..|   :....|.||..|.:.|.|:  :::.|...|
Yeast   431 SARKTSGSSNINDKIPGQSVPPPNSFFPQEPSPKISDFPEPRRSRRLRTKSFSN--KFQDIMVGP 493

Human   361 QITLNFVDLK-------GDPFLASPTSDREIIAPKIKERTHNV-TEKVTQVLSLGADVLPEYKLQ 417
            |   :|..::       |..||........:.|.|:..:...: ..|:.:||:       |.::.
Yeast   494 Q---SFEKIRLLGQGDVGKVFLVREKKTNRVYALKVLSKDEMIKRNKIKRVLT-------EQEIL 548

Human   418 APRIHRWTILHYSPFKAVWDWLILLL 443
            |...|.:.:..|..|::. |:|.|.:
Yeast   549 ATSNHPFIVTLYHSFQSE-DYLYLCM 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNH2	XP_047276304.1	PAS_9	64..156	CDD:463873
		Ion_trans	435..694	CDD:459842	3/9 (33%)
		CAP_ED	768..879	CDD:237999
FPK1	NP_014445.1	STKc_phototropin_like	494..797	CDD:270726	18/91 (20%)