Protein Alignment KCNH2 and sei

DIOPT Version :10

• Sequence 1: XP_047276304.1
• Gene: KCNH2 / 3757
• HGNCID: 6251
• Length: 1185
• Species: Homo sapiens
• Sequence 2: NP_476713.1
• Gene: sei / 37843
• FlyBaseID: FBgn0003353
• Length: 855
• Species: Drosophila melanogaster
• Alignment Length: 523
• Identity: 359/523 - (68%)
• Similarity: 423/523 - (80%)
• Gaps: 27/523 - (5%)

Human   381 DRE-IIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLV 444
            |:| ::..|.:.:..:..:.:|   |||.::|.:.|||....|:||:||||||||||||:||:||
  Fly   270 DKEALLGSKSEPKGQDPNDMIT---SLGGNILLDQKLQNNYYHKWTLLHYSPFKAVWDWIILILV 331

Human   445 IYTAVFTPYSAAFLLKETEEGPPATECGYA--------CQPLAVVDLIVDIMFIVDILINFRTTY 501
            :|||:||||.|||||.|.:         |.        ..|:.::|||||:.|||||:||||||:
  Fly   332 MYTAIFTPYVAAFLLGEQD---------YQRRNSKYINSDPIVIIDLIVDVTFIVDIIINFRTTF 387

Human   502 VNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEE---LIGLLKTARLLRLVRVAR 563
            ||:.:|||||||||||||..||||||:|||:|||||:.||.::|   ||||||||||||||||||
  Fly   388 VNSQDEVVSHPGRIAVHYLSGWFLIDLVAAVPFDLLLVGSDTDETTTLIGLLKTARLLRLVRVAR 452

Human   564 KLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGL 628
            |:|||||||||||.|||.||.|||||||||||||||.|:......||||::|...|.:||..:..
  Fly   453 KIDRYSEYGAAVLILLMATFILIAHWLACIWYAIGNAEKSIASKNIGWLNSLAYDIQEPYFDNRT 517

Human   629 GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLY 693
            ||||||.:|:|||||||:||||||||||:|||::||.|:|||||:||||||||||||||||||||
  Fly   518 GGPSIKSRYITALYFTFTSLTSVGFGNVAPNTDAEKAFTICVMLVGSLMYASIFGNVSAIIQRLY 582

Human   694 SGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 758
            ||||||||||||||||||||||||||||||||||||||:||||||||::||||||||||||||||
  Fly   583 SGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNSLLKGFPECLQADICLHL 647

Human   759 NRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILR-GDVVV 822
            ||.||..|..|..|:.|||||.::|||||||||||.|||.||:||:||||:||||||.| |::||
  Fly   648 NRKLLTTCAAFSEASPGCLRAFSLKFKTTHAPPGDILVHRGDVLTSLYFIARGSIEIQRAGNIVV 712

Human   823 AILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFN 887
              |||||||||...:|...|||||.||||||||:||:||||||:|||.||||.:.|.|:|.||:|
  Fly   713 --LGKNDIFGENPCIYPTVGKSNGVVRALTYCDIHKLHRDDLLDVLDSYPEFLESFVSNLVITYN 775

Human   888 LRD 890
            :||
  Fly   776 MRD 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNH2	XP_047276304.1	PAS_9	64..156	CDD:463873
		Ion_trans	435..694	CDD:459842	184/269 (68%)
		CAP_ED	768..879	CDD:237999	77/111 (69%)
sei	NP_476713.1	Ion_trans	322..583	CDD:459842	184/269 (68%)
		CAP_ED	657..767	CDD:237999	77/111 (69%)