Protein Alignment KCNH2 and kcnh2

DIOPT Version :10

• Sequence 1: XP_047276304.1
• Gene: KCNH2 / 3757
• HGNCID: 6251
• Length: 1185
• Species: Homo sapiens
• Sequence 2: XP_031759588.1
• Gene: kcnh2 / 100491983
• XenbaseID: XB-GENE-983104
• Length: 1194
• Species: Xenopus tropicalis
• Alignment Length: 1233
• Identity: 825/1233 - (66%)
• Similarity: 935/1233 - (75%)
• Gaps: 124/1233 - (10%)

Human    35 RRGRLS-----VPSLYSRISVKGRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDF 94
            |||.::     :.::..:...:.||||||||||||||||||||.||.:|||:|||||||||||||
 Frog     4 RRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDAFCAMCGYTRAEVMQRPCTCDF 68

Human    95 LHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKD-----GSCFLCLVDVVPVKNEDGAVIMFILN 154
            |:||||...:|:||||||:|:|||||||||||||     ||||||||||||||||||:|||||||
 Frog    69 LYGPRTTASSASQIAQALVGSEERKVEIAFYRKDVFGSVGSCFLCLVDVVPVKNEDGSVIMFILN 133

Human   155 FEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSVRSGGAGGAGAPGA 219
            ||||||||::.||..|:||: ..:.|...||.|:|:||||||||||..:.|:....      |..
 Frog   134 FEVVMEKDLLVSPNKDSNHK-VQSHWFPSGRGKSFKLKLPALLALTGSKQSLPQED------PDV 191

Human   220 VVVDVDLTPAAPSSESLALDE--VTAMDNHVAGLGPAEERRALVG---PGSPP------RSAPGQ 273
            ||||.    :..||:::||:|  :|.::|.:.  ..:|:::||:|   |.:||      .||...
 Frog   192 VVVDF----SKHSSDTVALEEMNLTPINNCIG--SQSEDQQALIGSKEPKAPPDEEGNKESAVQS 250

Human   274 LPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPPRHASTGAMHPLR 338
            .|......||.|.|.|:|||:|:|||||..|:|||||.|:||||:..:.....|::|||||:.:|
 Frog   251 SPHTDKDLLNLDMSFSNCSLSRSRSRESFYSIRRASSVDEIEAMKVDLEKFRNRNSSTGAMNNIR 315

Human   339 SGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAP-KIKERTHNVTEKVTQ 402
            :.||||||||||:|||||||||||||||||.|||.||.||::::||||| |:|:|||||||||||
 Frog   316 ANLLNSTSDSDLMRYRTISKIPQITLNFVDFKGDSFLTSPSNEKEIIAPSKLKDRTHNVTEKVTQ 380

Human   403 VLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPP 467
            ||||||||||||||||||||:|||||||||||||||||||||||||:||||||||||.:.||. .
 Frog   381 VLSLGADVLPEYKLQAPRIHKWTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLGDQEEA-E 444

Human   468 ATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAI 532
            ..:|||:|.||:|||||||||||:||||||||||||.|||||||||:||:|||||||||||||||
 Frog   445 NEQCGYSCNPLSVVDLIVDIMFIIDILINFRTTYVNTNEEVVSHPGKIAIHYFKGWFLIDMVAAI 509

Human   533 PFDLLIFGSGSEE--------------LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTF 583
            |||||||||||||              ||||||||||||||||||||||||||||||||||||||
 Frog   510 PFDLLIFGSGSEEIKRPDEGANKETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTF 574

Human   584 ALIAHWLACIWYAIGNMEQPHMDSR---IGWLHNLGDQIGKPYNSSGL-GGPSIKDKYVTALYFT 644
            ||||||||||||||||||  |.|..   ||||::||.||.|||||:.. .||||.||||||||||
 Frog   575 ALIAHWLACIWYAIGNME--HYDQEYRPIGWLYSLGIQIMKPYNSTNAKSGPSINDKYVTALYFT 637

Human   645 FSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREF 709
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   638 FSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREF 702

Human   710 IRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATK 774
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||:||||
 Frog   703 IRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQNCKPFKGATK 767

Human   775 GCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYA 839
            ||||||||||||||||||||||||||:|||:||:||||||||||||||||||||||||||:||||
 Frog   768 GCLRALAMKFKTTHAPPGDTLVHAGDVLTAVYFLSRGSIEILRGDVVVAILGKNDIFGEPINLYA 832

Human   840 RPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELE 904
            ||||||.|||||||||||||||:||||||||||||||:|||||||||||||||||||||.|.:.:
 Frog   833 RPGKSNADVRALTYCDLHKIHREDLLEVLDMYPEFSDYFWSSLEITFNLRDTNMIPGSPSSDDSD 897

Human   905 GGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRP-----GGPWGESPSSGPSSP 964
            .||:|.|:||||||||||||.|..||...    ....|..||..|     |..|.:..|:||||.
 Frog   898 SGFNRLRRRKLSFRRRTDKDAENAGEAKR----SQRMGRLSRNTPTCESKGLDWDKQLSTGPSSS 958

Human   965 ESSEDEGPGRSSSPLRLVP---------FSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGV 1020
            .||:||.|..||:.:.|.|         ||.||      |.|  .|....::|.||.||||||||
 Frog   959 SSSDDENPPPSSNTVELSPTRAMFTNSSFSVPR------GSE--AEGDNGTADVCNHLSGAFSGV 1015

Human  1021 SNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSAD 1085
            |||||||||..|.||||||||..|..:.|.....|..||.:.::.:|||.||:||||||:|:..|
 Frog  1016 SNIFSFWGDRAGGQYQELPRCTIPAHTALGGTAPSMSRRQKCEIGNRLDVLQKQLNRLESRMVTD 1080

Human  1086 MATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSP-------LPTL-----TLDSLSQVS 1138
            :.|::||||:|..|||||||.|::|        |.:|..|       .|.|     ||.|:|||.
 Frog  1081 INTIMQLLQKQAALVPPAYSTVSSP--------PQIPGYPPGGDHIVQPNLAGLSQTLASISQVY 1137

Human  1139 QFMACE-------ELP----PGAPELPQEGPTRRLSLPGQLGALTSQPL-----HRHGSDPGS 1185
            ::...|       |:|    |...| |::.|.|| ||||.|    ..||     .||.|||||
 Frog  1138 EYQELEGQRLDLCEMPLVPQPVNTE-PRDSPRRR-SLPGHL----EDPLDLRTPQRHSSDPGS 1194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNH2	XP_047276304.1	PAS_9	64..156	CDD:463873	78/96 (81%)
		Ion_trans	435..694	CDD:459842	227/276 (82%)
		CAP_ED	768..879	CDD:237999	102/110 (93%)
kcnh2	XP_031759588.1	PAS_9	38..135	CDD:463873	78/96 (81%)
		PLN03192	401..>866	CDD:215625	409/467 (88%)