Protein Alignment CG4752 and OPLAH

DIOPT Version :10

• Sequence 1: NP_611675.2
• Gene: CG4752 / 37569
• FlyBaseID: FBgn0034733
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: XP_047277644.1
• Gene: OPLAH / 26873
• HGNCID: 8149
• Length: 1389
• Species: Homo sapiens
• Alignment Length: 1312
• Identity: 785/1312 - (59%)
• Similarity: 949/1312 - (72%)
• Gaps: 73/1312 - (5%)

  Fly     5 KYCFAIDRGGTFTDVLCICPNGKVRTMKLLSEDPERYSDAPREGIRRILKEETGEDLAASGLVDT 69
            ::.||||||||||||...||.|.||.:|||||||..|:|||.|||||||::|.|..|.....:|:
Human   103 RFHFAIDRGGTFTDVFAQCPGGHVRVLKLLSEDPANYADAPTEGIRRILEQEAGMLLPRDQPLDS 167

  Fly    70 SKIGWVRMGTTVATNALLERKGDPVVLVVNSGFRDLLYIGNQARPKIFDLNIRKPANLYKSVVEV 134
            |.|..:||||||||||||||||:.|.|:|..||||||:||.|||..:|||.:..|..||:.|:||
Human   168 SHIASIRMGTTVATNALLERKGERVALLVTRGFRDLLHIGTQARGDLFDLAVPMPEVLYEEVLEV 232

  Fly   135 DCRIVPKQADRCELNHSWKELEGVAGT---------KYLEV-RPVDEVAVRQALSDARDQGVSSV 189
            |.|:|..:              |.|||         ..||| :|||..|:|..|.....:|:.|:
Human   233 DERVVLHR--------------GEAGTGTPVKGRTGDLLEVQQPVDLGALRGKLEGLLSRGIRSL 283

  Fly   190 SVVLAHSYACPEHELRVGAIARELGFSHVTLSHQAMPMCRVVARGYTACAEAYLTPHVDRYLASF 254
            :|||.|||...:||.:||.:||||||:||:||.:||||.|:|.||:||||:|||||.:.||:..|
Human   284 AVVLMHSYTWAQHEQQVGVLARELGFTHVSLSSEAMPMVRIVPRGHTACADAYLTPAIQRYVQGF 348

  Fly   255 KSGFDKQLEGVDVLFMQSDGGLTNMENFRGARAILSGPAGGVVGY-ALTGARETELPLIGFDMGG 318
            ..||..||:.|.||||:|||||..|:.|.|:.|:||||||||||| |.|..:|...|:|||||||
Human   349 CRGFQGQLKDVQVLFMRSDGGLAPMDTFSGSSAVLSGPAGGVVGYSATTYQQEGGQPVIGFDMGG 413

  Fly   319 TSTDVSRYAGTYEHVIESTTAGVTIQAPQLDINTVAAGGGSRLFFRSGIFVVGPESAGSHPGPAC 383
            ||||||||||.:|||.|::|||||:|||||||||||||||||||||||:|||||||||:||||||
Human   414 TSTDVSRYAGEFEHVFEASTAGVTLQAPQLDINTVAAGGGSRLFFRSGLFVVGPESAGAHPGPAC 478

  Fly   384 YKKGGPLTVTDANLILGRILPQYFPKIFGPQENEPLDHEIARSKFVELQAEINNYLKSSG-DNRV 447
            |:||||:|||||||:|||:||..||.||||.||:||..|.:|.....:..|:|::|.:.. ....
Human   479 YRKGGPVTVTDANLVLGRLLPASFPCIFGPGENQPLSPEASRKALEAVATEVNSFLTNGPCPASP 543

  Fly   448 LSVEDVALGFIRVANETMCRPIRALTQSRGLDTANHVLSCFGGAGGQHACSIARNLGIAKVVVHK 512
            ||:|:||:||:|||||.||||||||||:||.|.:.|||:|||||||||||:|||.||:..|.:|:
Human   544 LSLEEVAMGFVRVANEAMCRPIRALTQARGHDPSAHVLACFGGAGGQHACAIARALGMDTVHIHR 608

  Fly   513 YAGILSAYGMALADVVQEFQEPNGLEFSDANAQQLKERLDALSKQCQDKLSEQGFKR--IELEPF 575
            ::|:|||.|:||||||.|.|||..|.::.....||.:||..|.:||.|.|..|||.|  |..|.|
Human   609 HSGLLSALGLALADVVHEAQEPCSLLYAPETFVQLDQRLSRLEEQCVDALQAQGFPRSQISTESF 673

  Fly   576 LHLRYEGTDGALMVA----PSTGKQSSDSNPLLAAYGDFHATFLERYRTEFGFVLQNRRIIVDDI 636
            |||||:|||.||||:    |:|.:.        ...|||.|.|:|||..|||||:..|.::|||:
Human   674 LHLRYQGTDCALMVSAHQHPATARS--------PRAGDFGAAFVERYMREFGFVIPERPVVVDDV 730

  Fly   637 RIRGLGKN----ETPPESKVQAAAEAKPP-AEANTRLYFDQGAFDSPIYLTKNLLAGHRITGPAV 696
            |:||.|::    |..|:      |:..|| .:..|:.||:.|..::|:||...|..||::.||.:
Human   731 RVRGTGRSGLRLEDAPK------AQTGPPRVDKMTQCYFEGGYQETPVYLLAELGYGHKLHGPCL 789

  Fly   697 LIDQLSTIVVEPECGIQVTQFGDLIMDVKTGGKHGINADLDPVHLSIFSHRFMSIAEQMGRVLQR 761
            :||..|||:|||.|..:||:.||:.:.|.......:...|||:.|||||||||||||||||:|||
Human   790 IIDSNSTILVEPGCQAEVTKTGDICISVGAEVPGTVGPQLDPIQLSIFSHRFMSIAEQMGRILQR 854

  Fly   762 TSISTNIKERLDFSCALFGPDGGLVSNAPHIPVHLGAMQETVQYQLRVRGETLKNGDVILANHPS 826
            |:|||||||||||||||||||||||||||||||||||||||||:|::..|..|..|||:|:||||
Human   855 TAISTNIKERLDFSCALFGPDGGLVSNAPHIPVHLGAMQETVQFQIQHLGADLHPGDVLLSNHPS 919

  Fly   827 AGGSHLPDLTVITPVFYETHPRPVFFVASRGHHADIGGITPGSMPPHSTSLAQEGAAFKSFLIVE 891
            ||||||||||||||||:....||||:|||||||||||||||||||||||.|.||||.|.||.:|:
Human   920 AGGSHLPDLTVITPVFWPGQTRPVFYVASRGHHADIGGITPGSMPPHSTMLQQEGAVFLSFKLVQ 984

  Fly   892 NGLFQEQQIIEQLTTPTAAKGAVGTRNLSDNLSDLKAQIAANHKGIQLVAELIGSYGLDVVQAYM 956
            .|:|||:.:.|.|..|.......|||||.||||||:||:|||.||||||.||||.||||||||||
Human   985 GGVFQEEAVTEALRAPGKVPNCSGTRNLHDNLSDLRAQVAANQKGIQLVGELIGQYGLDVVQAYM 1049

  Fly   957 SHIQKNAELAVRDMLRQIGRDTLERTGSTVLEAKEFMDDGSPIALKVTIDAEQGSALCDFTGSGV 1021
            .|||.|||||||||||..|.....|.....:.:::.|||||||.|:|.|...||||:.||:|:|.
Human  1050 GHIQANAELAVRDMLRAFGTSRQARGLPLEVSSEDHMDDGSPIRLRVQISLSQGSAVFDFSGTGP 1114

  Fly  1022 EVWGNCNAPRAITLSALIYCLRCMVGHDVPLNQGCLAPIQVIIPKNSILDPSEGAAVVGGNVQTS 1086
            ||:||.|||||:|||||||||||:||.|:|||||||||::|:||:.||||||..||||||||.||
Human  1115 EVFGNLNAPRAVTLSALIYCLRCLVGRDIPLNQGCLAPVRVVIPRGSILDPSPEAAVVGGNVLTS 1179

  Fly  1087 QRIVDTVLKAFGVCAASQGCMNNITIGDESWGYYETVAGGAGAGPGWHGAGGVHTHMTNTRITDP 1151
            ||:||.:|.|||.||||||||||:|:|:...||||||||||||||.|||..|||:||||||||||
Human  1180 QRVVDVILGAFGACAASQGCMNNVTLGNAHMGYYETVAGGAGAGPSWHGRSGVHSHMTNTRITDP 1244

  Fly  1152 EILELRYPMILKRFCLRTDGSGGRGQFHGGEGVERDLLFRKPVTLSVLTERRTLQPYGLAGGESG 1216
            ||||.|||:||:||.||. ||||||:|.||:||.|:||||:...||||||||..:||||.|||.|
Human  1245 EILESRYPVILRRFELRR-GSGGRGRFRGGDGVTRELLFREEALLSVLTERRAFRPYGLHGGEPG 1308

  Fly  1217 KSGRNLVVKRDGRVIALAGKTCIDVEAGDTFA--------MKTPGG---GGYGP----------I 1260
            ..|.||:::::||.:.|.|||.:.|..||..:        ....||   ||.||          :
Human  1309 ARGLNLLIRKNGRTVNLGGKTSVTVYPGDRKSSCSCSSRWSAERGGRAVGGAGPPGSAPPRPPLL 1373

  Fly  1261 EDFSKSGESLNQ 1272
            .|.|.|..||.:
Human  1374 LDLSSSYRSLGR 1385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4752	NP_611675.2	PLN02666	5..1262	CDD:215358	780/1300 (60%)
OPLAH	XP_047277644.1	Speriolin_N	1..>66	CDD:434426
		PLN02666	96..1338	CDD:215358	773/1263 (61%)