Protein Alignment CG10384 and QKI

DIOPT Version :10

• Sequence 1: NP_611673.3
• Gene: CG10384 / 37567
• FlyBaseID: FBgn0034731
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_006766.1
• Gene: QKI / 9444
• HGNCID: 21100
• Length: 341
• Species: Homo sapiens
• Alignment Length: 142
• Identity: 59/142 - (41%)
• Similarity: 90/142 - (63%)
• Gaps: 13/142 - (9%)

  Fly    32 VKVAVKVAVPVRDHPKFNFVGKLLGPKGNSMKRLQEDTMCKMAVLGRGSMRDRRKEEELRGSGDS 96
            |::..|:.|||:::|.|||||::|||:|.:.|:|:.:|.||:.|.|:|||||::|||:.||.  .
Human    80 VQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQNRGK--P 142

  Fly    97 RYAHLFEDLHVEISTFAAPAEAHARIAYALAEVRRFLVP--DYHDDIRQEQMWEMQALTST---- 155
            .:.||.|||||.|:...|...|..::..|:.||::.|||  :..|.:::.|:.|:..|..|
Human   143 NWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPAAEGEDSLKKMQLMELAILNGTYRDA 207

  Fly   156 ----PALGAHSL 163
                ||| |.||
Human   208 NIKSPAL-AFSL 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10384	NP_611673.3	KH-I_KHDRBS	43..131	CDD:411812	40/87 (46%)
QKI	NP_006766.1	STAR_dimer	10..64	CDD:435414
		Qua1 domain, involved in homodimerization. /evidence=ECO:0000250|UniProtKB:Q17339	11..82		1/1 (100%)
		KH-I_Hqk	81..183	CDD:411893	47/103 (46%)
		Qua2 domain, involved in RNA binding. /evidence=ECO:0000269|PubMed:23630077	182..213		5/30 (17%)
		PHA03247	<211..314	CDD:223021	6/9 (67%)
		SH3-binding	276..279
		Quaking_NLS	312..341	CDD:435421
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9QYS9	324..330