DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10384 and SF1

DIOPT Version :9

Sequence 1:	NP_001163254.2	Gene:	CG10384 / 37567	FlyBaseID:	FBgn0034731	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001365886.1	Gene:	SF1 / 7536	HGNCID:	12950	Length:	764	Species:	Homo sapiens

Alignment Length:	516	Identity:	109/516 - (21%)
Similarity:	172/516 - (33%)	Gaps:	171/516 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LEERSLKGSEKL---------KMLDITRD-------KP--VKVAVKVAVPVRDHPKFNFVGKLLG 56
            |..|..:..:||         :|:.:..|       ||  .:|:.||.:|..::|:.||||.|:|
Human   219 LNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIG 283

  Fly    57 PKGNSMKRLQEDTMCKMAVLGRGSMRD---RRKEEELRGSGDSRYAHLFEDLHVEISTFAAPAEA 118
            |:||::|.::::...|:.:.|:||:::   .||:.::....|       |.||..::     |..
Human   284 PRGNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGED-------EPLHALVT-----ANT 336

  Fly   119 HARIAYALAEVRRFL-----VPDYHDDIRQEQMWEMQALTSTPALGAHSLEDSHSPTIN--SSSQ 176
            ...:..|:.::|..|     .|:..:|:|:.|:.|:..|..|       |.:..:..:.  .||:
Human   337 MENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGT-------LREDDNRILRPWQSSE 394

  Fly   177 VGGTTNSSSNGASGRGLGGGLADMDTSNDDKSDDASGM-------ECLSAVDKLDCSSSCASLG- 233
            ....||::.....|   |.|....|.......|..|..       |.||.:.:|..:...||:|
Human   395 TRSITNTTVCTKCG---GAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGS 456

  Fly   234 ISGITT---------------------ISTTSPEHP----HPHQHHQQHQQH--------QQHHA 265
            .||..|                     :|||....|    .|.:....|..|        ...|:
Human   457 TSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHS 521

  Fly   266 HLHP----AHAHGNQQQQ------------------QQVQHHHSHQAHFHQLLQQAHGGASAAAA 308
            ..||    ...||....|                  .|..|...|  |....:.|..|.....:.
Human   522 FPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGH--HGPPPMDQYLGSTPVGSG 584

  Fly   309 ACGEHL--------------------SGQTTPATAAAL-----------------HTTAMAVALQ 336
            ....|.                    |||..|..:..|                 .:.|.:..|.
Human   585 VYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLP 649

  Fly   337 HQ------LTAAGIGGLLKPATGVGATMAGLPTTQAGAAALQLPGDGESSGSTLTLLEPPG 391
            .|      .|:||.|.:  |           |..|..|||...||..:..|:...:..|||
Human   650 WQQNTTTTTTSAGTGSI--P-----------PWQQQQAAAAASPGAPQMQGNPTMVPLPPG 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10384	NP_001163254.2	SF1_like-KH	44..155	CDD:239088	31/118 (26%)
SF1	NP_001365886.1	MSL5	142..382	CDD:227503	45/181 (25%)
SF1	NP_001365886.1	ZnF_C2HC	403..418	CDD:197667	4/17 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910