DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10384 and Sf1

DIOPT Version :9

Sequence 1:	NP_001163254.2	Gene:	CG10384 / 37567	FlyBaseID:	FBgn0034731	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001104261.1	Gene:	Sf1 / 22668	MGIID:	1095403	Length:	639	Species:	Mus musculus

Alignment Length:	516	Identity:	109/516 - (21%)
Similarity:	173/516 - (33%)	Gaps:	171/516 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LEERSLKGSEKL---------KMLDITRD-------KP--VKVAVKVAVPVRDHPKFNFVGKLLG 56
            |..|..:..:||         :|:.:..|       ||  .:|:.||.:|..::|:.||||.|:|
Mouse    94 LNTREFRTRKKLEEERHTLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIG 158

  Fly    57 PKGNSMKRLQEDTMCKMAVLGRGSMRD---RRKEEELRGSGDSRYAHLFEDLHVEISTFAAPAEA 118
            |:||::|.::::...|:.:.|:||:::   .||:.::....|       |.||..::     |..
Mouse   159 PRGNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGED-------EPLHALVT-----ANT 211

  Fly   119 HARIAYALAEVRRFL-----VPDYHDDIRQEQMWEMQALTSTPALGAHSLEDSHSPTIN--SSSQ 176
            ...:..|:.::|..|     .|:..:|:|:.|:.|:..|..|       |.:..:..:.  .||:
Mouse   212 MENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGT-------LREDDNRILRPWQSSE 269

  Fly   177 VGGTTNSSSNGASGRGLGGGLADMDTSNDDKSDDASGM-------ECLSAVDKLDCSSSCASLG- 233
            ....||::.....|   |.|....|.......|..|..       |.||.:.:|..:...||:|
Mouse   270 TRSITNTTVCTKCG---GAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGS 331

  Fly   234 ISGITT---------------------ISTTSPEHP----HPHQHHQQHQQH--------QQHHA 265
            .||..|                     :|||....|    .|.::...|..|        ...|:
Mouse   332 TSGPATTPLASAPRPAAPASNPPPPSLMSTTQSRPPWMNSGPSENRPYHGMHGGGPGGPGGGPHS 396

  Fly   266 HLHP----AHAHGNQQQQ------------------QQVQHHHSHQAHFHQLLQQAHGGASAAAA 308
            ..||    ...||....|                  .|..|...|  |....:.|..|.....:.
Mouse   397 FPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGH--HGPPPMDQYLGSTPVGSG 459

  Fly   309 ACGEHL--------------------SGQTTPATAAAL-----------------HTTAMAVALQ 336
            ....|.                    |||..|..:..|                 .:.|.:..|.
Mouse   460 VYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLP 524

  Fly   337 HQ------LTAAGIGGLLKPATGVGATMAGLPTTQAGAAALQLPGDGESSGSTLTLLEPPG 391
            .|      .|:||.|.:  |           |..|..|||...||..:..|:...:..|||
Mouse   525 WQQNTTTTTTSAGTGSI--P-----------PWQQQQAAAAASPGTPQMQGNPTMVPLPPG 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10384	NP_001163254.2	SF1_like-KH	44..155	CDD:239088	31/118 (26%)
Sf1	NP_001104261.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Nuclear localization signal. /evidence=ECO:0000255	15..19
		MSL5	17..257	CDD:227503	45/181 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..94		109/516 (21%)
		ZnF_C2HC	278..293	CDD:197667	4/17 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	325..584		50/263 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910