DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10384 and Khdrbs1

DIOPT Version :9

Sequence 1:	NP_001163254.2	Gene:	CG10384 / 37567	FlyBaseID:	FBgn0034731	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_569089.1	Gene:	Khdrbs1 / 117268	RGDID:	621459	Length:	443	Species:	Rattus norvegicus

Alignment Length:	200	Identity:	90/200 - (45%)
Similarity:	118/200 - (59%)	Gaps:	29/200 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LSALEERSLKGSEKL----KMLDITRDKPVKVAVKVAVPVRDHPKFNFVGKLLGPKGNSMKRLQE 67
            ||...|:..||..|.    ..||:...|.:|:..:|.:||:.:||||||||:|||:||::|||||
  Rat   125 LSVEIEKIQKGESKKDDEENYLDLFSHKNMKLKERVLIPVKQYPKFNFVGKILGPQGNTIKRLQE 189

  Fly    68 DTMCKMAVLGRGSMRDRRKEEELRGSGDSRYAHLFEDLHVEISTFAAPAEAHARIAYALAEVRRF 132
            :|..|::|||:|||||:.||||||..||.:||||..||||.|..|..|.||:|.:|:|:.||::|
  Rat   190 ETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDLHVFIEVFGPPCEAYALMAHAMEEVKKF 254

  Fly   133 LVPDYHDDIRQEQMWEMQALTSTPALGAHSLEDSHSPTINSSSQVGGTTNSSSNGAS-------- 189
            ||||..|||.|||..|:..|...|           .|:......|.|      .||:
  Rat   255 LVPDMMDDICQEQFLELSYLNGVP-----------EPSRGRGVSVRG------RGAAPPPPPVPR 302

  Fly   190 GRGLG 194
            |||:|
  Rat   303 GRGVG 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10384	NP_001163254.2	SF1_like-KH	44..155	CDD:239088	67/110 (61%)
Khdrbs1	NP_569089.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..95
		Involved in homodimerization. /evidence=ECO:0000250\|UniProtKB:Q07666	100..260		72/134 (54%)
		Qua1	102..153	CDD:406639	8/27 (30%)
		KH-I	152..257	CDD:412160	61/104 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..317		8/33 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..345
		Interaction with HNRNPA1. /evidence=ECO:0000250\|UniProtKB:Q07666	351..443
		Sam68-YY	366..415	CDD:406871
		Interaction with ZBTB7A. /evidence=ECO:0000250\|UniProtKB:Q07666	400..420
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348942
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1012406at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950