Protein Alignment ppk12 and ASIC3

DIOPT Version :10

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_064717.1
• Gene: ASIC3 / 9311
• HGNCID: 101
• Length: 549
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 133/607 - (21%)
• Similarity: 218/607 - (35%)
• Gaps: 189/607 - (31%)

  Fly     5 PSAGTE--RQGSSLFLLKSFVRSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVH 67
            |::|.|  |:.:|         .:|.|.:..|:|||..|...|..|..|    |.:..|::::|
Human     3 PTSGPEEARRPAS---------DIRVFASNCSMHGLGHVFGPGSLSLRR----GMWAAAVVLSV- 53

  Fly    68 LISNIYVKWDSTPVIIGISPQATSILKVP------------------------FPAITICNMNQV 108
                                 ||.:.:|.                        |||:|:||:|.:
Human    54 ---------------------ATFLYQVAERVRYYREFHHQTALDERESHRLIFPAVTLCNINPL 97

  Fly   109 QRS-LVANYREGSNESALLKLLCESDSWESS---------EADEEFSASNFVTNNLKISEFVSNH 163
            :|| |..|....:. ||||.|    |..|.:         .|...|..|    ....:::..:..
Human    98 RRSRLTPNDLHWAG-SALLGL----DPAEHAAFLRALGRPPAPPGFMPS----PTFDMAQLYARA 153

  Fly   164 SQSCERMLLFCRFSAVERNCS-QLFQQILTDEGLCCVFNFQPPEYLYKPFANNNRNLTNSDGFES 227
            ..|.:.|||.|||..  :.|. :.|..|.|..|.|..||                  :.:||.|.
Human   154 GHSLDDMLLDCRFRG--QPCGPENFTTIFTRMGKCYTFN------------------SGADGAEL 198

  Fly   228 VMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLDAEMGEY---YCSSTNGP---GFKVYFHNP 286
            :                   |.:..|:..|...:||.:..||   :..:...|   |.:|..|:.
Human   199 L-------------------TTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQ 244

  Fly   287 IEVPKVKEAGLISAIGYETNYRIEMVRAEAVP------AIRSISRDGRQCLFKNEKELIFYR--- 342
            .|.|.:.:.||..:.||:|....:..:...:|      :..|::.:              |.
Human   245 EEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPN--------------YEPEP 295

  Fly   343 -------------IYTRLNCENECLAAFLYDTCSC----IPFDHPLIYSNASICSMGD-TSCVRR 389
                         .||.:.|...|...::...|.|    :|.|.|       :||... .:|...
Human   296 SDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVP-------VCSPQQYKNCAHP 353

  Fly   390 AQRASNRPGWAKCRQQCLPSCFDLNYLASGFSFPLASNNFQLANALVESFNKS--YLSKNIAVIN 452
            |..|..|.....|...|..:.:     |...|.....:. ..|..|....|:|  |:::|:..::
Human   354 AIDAMLRKDSCACPNPCASTRY-----AKELSMVRIPSR-AAARFLARKLNRSEAYIAENVLALD 412

  Fly   453 VYFRESVYYGNT--KNAYVGLTEFLSNVGGVMGLFMGFSVISLAEILYFL--ILKPLAELFVWKR 513
            ::| |::.|...  |.|| .::|.|.::||.||||:|.|::::.|||.:|  :.:.....:.|.|
Human   413 IFF-EALNYETVEQKKAY-EMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNR 475

  Fly   514 S-SHVDSEKSLKHNAFGIEKGQ 534
            . |...|..:|.....|..:.|
Human   476 QHSQRHSSTNLLQEGLGSHRTQ 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	ASC	29..499	CDD:459966	119/541 (22%)
ASIC3	NP_064717.1	ENaC	20..534	CDD:273304	127/581 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..307		2/35 (6%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	447..449		1/1 (100%)