Protein Alignment ppk12 and asic1a

DIOPT Version :10

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_999955.1
• Gene: asic1a / 791696
• ZFINID: ZDB-GENE-040513-2
• Length: 501
• Species: Danio rerio
• Alignment Length: 571
• Identity: 130/571 - (22%)
• Similarity: 218/571 - (38%)
• Gaps: 176/571 - (30%)

  Fly    26 LRQFLNQTSLHGLKFVGDSGLSSWER---------SFFLGSFVTALIITVHLISNIYVKWD---- 77
            |:.|.:.::|||:     |.:.|:|:         .|||.|....:.:.:..| ..|:::.
Zfish    23 LQVFAHTSTLHGI-----SHIFSYEKITAKCCLWVVFFLSSLTFLMYVCIDRI-QFYLEYPHVTK 81

  Fly    78 ----STPVIIGISPQATSILKVPFPAITICNMNQVQRSLVAN---YREGSNESALLKL------- 128
                :|||::             |||:||||:|.::.|.:..   |..|.    ||.|
Zfish    82 LDEITTPVMV-------------FPAVTICNLNSIRFSRITRNDLYHAGE----LLALLNSRHEV 129

  Fly   129 ----LCESDSWESSEADEEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNC-SQLFQ 188
                |.|....|..::..:|  .:|...:..:.||.:......:.|||.|:|..  ..| .:.|.
Zfish   130 REAHLVEESVMEVLKSKTDF--RSFKPRHFNMWEFYNRTGHDIKDMLLSCQFRG--SPCRPEDFS 190

  Fly   189 QILTDEGLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTG 253
            .:.|..|.|..||                                ||  |..||:.......|.|
Zfish   191 VVFTRYGKCYTFN--------------------------------SG--ETGPPRVSVKGGMGNG 221

  Fly   254 ITLGFTAVLDAEMGEYY------CSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMV 312
            :.:    :||.:..||.      ..|:...|.||..|:..|.|.:.:.|...|.|::|....:..
Zfish   222 LEI----MLDIQQDEYLPVWGESDESSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQ 282

  Fly   313 RAEAVPA----IRSI--SRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSC----IPF 367
            |...:||    .:|.  |.|             ::|.|:...|..:|...:|.:.|:|    :|.
Zfish   283 RLVYLPAPWGSCKSTPPSSD-------------YFRAYSISACRTDCETRYLVENCNCRMVHMPG 334

  Fly   368 D-------------HP----LIYSNASICSMGDTSCVRRAQRASNRPGWAKCRQQCLPSCFDLNY 415
            |             ||    |:.:::..||. :|.|  ...|.|....:.|     :||...:.|
Zfish   335 DAPYCTPVLYKECAHPALDFLVETDSDYCSC-ETPC--NITRYSKELSFVK-----IPSKASVKY 391

  Fly   416 LASGFSFPLASNNFQLANALVESFNKSYLSKNIAVINVYFRESVYYG--NTKNAY--VGLTEFLS 476
            ||..:                 |.::.|:::|:.|::|:| |::.|.  ..:.||  .||   |.
Zfish   392 LAKKY-----------------SKSEKYITENVMVLDVFF-EALNYETIEQRKAYEVAGL---LG 435

  Fly   477 NVGGVMGLFMGFSVISLAEILYFLILKPLAELFVWKRSSHVDSEKSLKHNA 527
            ::||.||||:|.|::::.|:..:|.......|.......|.::..:..|||
Zfish   436 DIGGQMGLFIGASILTILELFDYLYEVMKYRLCRCSNKKHHNNNNNTDHNA 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	ASC	29..499	CDD:459966	123/538 (23%)
asic1a	NP_999955.1	ENaC	23..469	CDD:273304	126/552 (23%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:Q1XA76	446..448		1/1 (100%)