DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk12 and Asic1

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_006257440.1	Gene:	Asic1 / 79123	RGDID:	71062	Length:	559	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	121/534 - (22%)
Similarity:	191/534 - (35%)	Gaps:	171/534 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVKWDSTPVIIGISPQ 88
            |.|..|.|..:|||...|...|.....::.:..:||.||...:..:.:....:.|.|.:..:...
  Rat    61 RDLVAFANSCTLHGASHVFVEGGPGPRQALWAVAFVIALGAFLCQVGDRVAYYLSYPHVTLLDEV 125

  Fly    89 ATSILKVPFPAITICNMNQVQRSLVANYREGSNESALLKL-----LCESDSWE---SSEADEEFS 145
            ||:  ::.|||:|.||.|.|:.|.: :|.:      ||.|     |.|||...   :....|.||
  Rat   126 ATT--ELVFPAVTFCNTNAVRLSQL-SYPD------LLYLAPMLGLDESDDPGVPLAPPGPEAFS 181

  Fly   146 ASNFVTNNLKISEFVSNHSQSCER---MLLFCRFSAVERNCS-----QLFQQILTDEGLCCVFNF 202
            ...|     .:..|   :::||.|   |||:|.:      |.     ..|..:.|..|.|..||
  Rat   182 GEPF-----NLHRF---YNRSCHRLEDMLLYCSY------CGGPCGPHNFSVVFTRYGKCYTFN- 231

  Fly   203 QPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLDAEMG 267
                                        ..:.|.|.....|      .|||  .|...:||.:..
  Rat   232 ----------------------------SGQDGRPRLKTMK------GGTG--NGLEIMLDIQQD 260

  Fly   268 EYY------CSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPA----IRS 322
            ||.      ..::...|.||..|:..|.|.:.:.|...|.|::|....:..|...:|:    ..:
  Rat   261 EYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLIYLPSPWGTCNA 325

  Fly   323 ISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSC----IPFDHPLIYSNASICSMGD 383
            ::.|..           |:..|:...|..:|...:|.:.|:|    :|.|.|.
  Rat   326 VTMDSD-----------FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY------------ 367

  Fly   384 TSCVRRAQRASNRPG----------WAKCRQQC-------------LPSCFDLNYLASGFSFPLA 425
              |.....:....|.          :..|...|             :||.....|||
  Rat   368 --CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLA-------- 422

  Fly   426 SNNFQLANALVESFNKS--YLSKNIAVINVYFR----ESVYYGNTKNAY--VGLTEFLSNVGGVM 482
                       :.||||  |:.:||.|::::|.    |::   ..|.||  .||   |.::||.|
  Rat   423 -----------KKFNKSEQYIGENILVLDIFFEVLNYETI---EQKKAYEIAGL---LGDIGGQM 470

  Fly   483 GLFMGFSVISLAEI 496
            |||:|.|::::.|:
  Rat   471 GLFIGASILTVLEL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	119/530 (22%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	119/529 (22%)
Asic1	XP_006257440.1	ASC	63..541	CDD:295594	120/532 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345633
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8907
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.850