DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and Asic4

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_071570.2	Gene:	Asic4 / 63882	RGDID:	621068	Length:	539	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	119/553 - (21%)
Similarity:	197/553 - (35%)	Gaps:	176/553 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVKWDSTPVIIGISPQ 88
            |.|..|.:.::||||......|.....|:.::.:.:|:|...::..:::...:.:.|.::.:.|.
  Rat    40 RDLATFASTSTLHGLGRACGPGPHGLRRTLWVLALLTSLAAFLYQAASLARGYLTRPHLVAMDPA 104

  Fly    89 ATSILKVPFPAITICNMNQVQRSLVANY---------------REGSNESALLKLLCESDSWESS 138
            |.:.: ..|||:|:||:|:.:.|.:::.               |:|...:.|          ...
  Rat   105 APAPV-AGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGL----------RYP 158

  Fly   139 EADEEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNCS-QLFQQILTDEGLCCVFNF 202
            |.|              :.:.::........||..|.||.  .:|| ..|..:.|..|.|..||.
  Rat   159 EPD--------------MVDILNRTGHQLADMLKSCNFSG--HHCSASNFSVVYTRYGKCYTFNA 207

  Fly   203 QPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLDAEMG 267
                                        ||:|..|.:         |.|.|  .|...:||.:..
  Rat   208 ----------------------------DPQSSLPSR---------AGGMG--SGLEIMLDIQQE 233

  Fly   268 EY--YCSSTN----GPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPA----IRS 322
            ||  ....||    ..|.:|..|:..|.|.:.:.|...:.|::|....:..|...:|.    .|:
  Rat   234 EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRA 298

  Fly   323 ISRDGRQCLFKNEKELIFYRIYT----RLNCENECLAAFLYDTCSCIPFDHPLIYSNASIC---- 379
            .|:       ..|.||..|..|:    ||.||.|.    :...|.|.....|   .|.:||
  Rat   299 ESK-------LREPELQGYSAYSVSACRLRCEKEA----VLQRCHCRMVHMP---GNETICPPNI 349

  Fly   380 ----------SMGDTSCVRRAQRASNRPGWAKCRQQC-------------LPSCFDLNYLASGFS 421
                      |:|..|           .|...|...|             :|:.....|||..:
  Rat   350 YIECADHTLDSLGGGS-----------EGPCFCPTPCNLTRYGKEISMVKIPNRGSARYLARKY- 402

  Fly   422 FPLASNNFQLANALVESFNKSYLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFM 486
                            :.|::|:.:|..|::|:|.........:.|..||:..|.::||.||||:
  Rat   403 ----------------NRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFI 451

  Fly   487 GFSVISLAEILYFLI------LKPLAELFVWKR 513
            |.|:::|.|||.::.      ||.     ||:|
  Rat   452 GASILTLLEILDYIYEVSWDRLKR-----VWRR 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	112/527 (21%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	112/526 (21%)
Asic4	NP_071570.2	ASC	40..488	CDD:295594	119/553 (22%)
Asic4	NP_071570.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345671
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8907
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.750