DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and Asic5

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_071563.1	Gene:	Asic5 / 63866	RGDID:	69295	Length:	495	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	132/558 - (23%)
Similarity:	205/558 - (36%)	Gaps:	162/558 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PSPSAGTERQGSSLFLLKSFVRSLRQFLNQTSLHGLKFVGDSGLS----SWERSFFLGSFVTALI 63
            |||   |:|        |.|.   ..|...||.||:..:..:...    .| .|..||| |:.|:
  Rat    29 PSP---TDR--------KKFD---HDFAISTSFHGIHNIAQNQNKVRKVIW-LSVVLGS-VSLLV 77

  Fly    64 ITVHLISNIYVKWDSTPVIIGISPQATSILKVPFPAITICNMNQVQRSLVANYREG------SNE 122
            ..::.....|..|.:|..|     :...:.|:.|||:|.||:|:.|...|:.:  |      ...
  Rat    78 WQIYSRLVNYFMWPTTTSI-----EVQYVEKIEFPAVTFCNLNRFQTEAVSRF--GIIFFLWDIV 135

  Fly   123 SALLKLLCESDSWESSEADEEFSASNFVTNNLKISEFVSNHSQSCER-MLLFCRFSAVERNCS-Q 185
            |.:|:|...|.:...|....:|.||:   .|..|:|||.|:...... .|:.|.|..  :.|. :
  Rat   136 SKVLRLQEISGNNTGSPEALDFVASH---RNFSITEFVKNNGFYLNHDTLVHCEFFG--KTCDPK 195

  Fly   186 LFQQILTDEGLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATAS 250
            .|:.:.|:.|.|..||                                  |.|.:..| ...:.|
  Rat   196 DFKHVFTEYGNCFTFN----------------------------------YGENVQSK-NKVSVS 225

  Fly   251 GTGITLGFTAVLDAEMGEYYCSSTNGPGFK---VYF--HNPIEVPKVKEAGLISAIGYETNYRIE 310
            |.|:.|    :||....|:  :....|||.   |.|  |:|.:.|:....||.|.:|......|.
  Rat   226 GRGLKL----LLDVHQEEF--TDNPVPGFADAGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIR 284

  Fly   311 MVR--------AEAVPAIRSISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSCIPF 367
            .::        .|..|.|:          .:|      :..|:...|..||.|..:...|.|:||
  Rat   285 QLKTIHQEYPWGECNPDIK----------LRN------FTTYSTYGCLKECKAKHIQRLCGCLPF 333

  Fly   368 DHP--------LIYSNA-----------SICSMGDTSCVRRAQRASNRPGWAKCRQQCLPSCFDL 413
            ..|        |.|.|.           .:|:||..:                  ..|...|.:.
  Rat   334 LLPGNGVECDLLKYYNCVSPILDHIERKGLCTMGTHN------------------SSCPVPCEET 380

  Fly   414 NYLASGFSFPLASNNFQLANA---LVESFNKS--YLSKNIAVINVYFRESVYYGNTKNAYVGLTE 473
            .|.|:     :|.:.|....|   |.:..|:|  |:.:|:..|.:.:.:..|....:...|.:.|
  Rat   381 EYPAT-----IAYSTFPSQRATKFLAKKLNQSQEYIRENLVNIEINYSDLNYKITQQQKAVSVPE 440

  Fly   474 FLSNVGGVMGLFMGFSVISLAEILYFLILKPLAELFVW 511
            .|::|||.:|||.|.|:|::.||:.:|...     |.|
  Rat   441 LLADVGGQLGLFCGASLITIIEIIEYLFTS-----FYW 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	122/519 (24%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	122/518 (24%)
Asic5	NP_071563.1	deg-1	40..465	CDD:273309	122/518 (24%)
Asic5	NP_071563.1	ASC	41..466	CDD:279230	122/518 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8907
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720