Protein Alignment ppk12 and SCNN1G

DIOPT Version :9

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_001030.2
• Gene: SCNN1G / 6340
• HGNCID: 10602
• Length: 649
• Species: Homo sapiens
• Alignment Length: 659
• Identity: 128/659 - (19%)
• Similarity: 222/659 - (33%)
• Gaps: 236/659 - (35%)

  Fly    26 LRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVKWDSTPVIIGISPQAT 90
            :|.:...|:.||.:.:..| .....|..::|..:||:.:         :.|....::......:.
Human    29 MRWYCLNTNTHGCRRIVVS-RGRLRRLLWIGFTLTAVAL---------ILWQCALLVFSFYTVSV 83

  Fly    91 SI----LKVPFPAITICNMNQVQ----RSLVANYREGSNESALLKLLC---------ESDSWES- 137
            ||    .|:.|||:||||:|..:    |.|:|:..:.:.|:  ||.|.         |::||.|
Human    84 SIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREA--LKSLYGFPESRKRREAESWNSV 146

  Fly   138 SEA----------------DEEFSASNFVTNNLK------------------------------- 155
            ||.                ||:..|.:|.|...:
Human   147 SEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSNDT 211

  Fly   156 --------------ISEFVSNH----------------SQSCERMLLFCRFSAVE---RNCSQLF 187
                          |.|:...|                |.|.|.:|:.|.|..|.   ||.: ||
Human   212 SDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDARNFT-LF 275

  Fly   188 QQILTDEGLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGT 252
            ...:  .|.|..|             ||..|       |:::                 :|:.|
Human   276 HHPM--HGNCYTF-------------NNREN-------ETIL-----------------STSMG- 300

  Fly   253 GITLGFTAVL---DAEMGEYYCSSTNGPGFKVYFHNPIEVPKVKEAG------LISAIGYETNYR 308
            |...|...:|   :.|...:..|||   |.||..|...|.|.|::.|      ::::||......
Human   301 GSEYGLQVILYINEEEYNPFLVSST---GAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTES 362

  Fly   309 IEMVRAEAVPAIRSISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSCIPFDHPLIY 373
            .::....:     ..:.||.....:|    |:...|:...|.:.|....:.:.|.|..:..||..
Human   363 FKLSEPYS-----QCTEDGSDVPIRN----IYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPP 418

  Fly   374 SNASICSMGDTSCVRRAQRASNRPGWAKCRQQ-----------CLPSCFDLNYLASGF-SFPLAS 426
            : |:.|:.            ...|.|..|..|           |...|.:    |..| .:.|.:
Human   419 A-ANYCNY------------QQHPNWMYCYYQLHRAFVQEELGCQSVCKE----ACSFKEWTLTT 466

  Fly   427 NNFQLANALVESF-------------NKSYLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNV 478
            :..|..:.:.|.:             ||.....::|.:.:::::.......::....:...|||.
Human   467 SLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNF 531

  Fly   479 GGVMGLFMGFSVISLAEIL------YFLIL-----KPLAELFVWKRSSHV-DSEKSLKHNAFGIE 531
            ||.:||:|..||:.:.||:      :|.|:     :...|.:.||::... ::.:|
Human   532 GGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWQKAKEWWAWKQAPPCPEAPRS--------- 587

  Fly   532 KGQSSDNPS 540
             .|..|||:
Human   588 -PQGQDNPA 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	117/608 (19%)
		ASC	29..499	CDD:279230	117/607 (19%)
SCNN1G	NP_001030.2	ENaC	24..630	CDD:273304	128/659 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152168
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.650