Protein Alignment ppk12 and SCNN1D

DIOPT Version :10

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Alignment Length: 644
• Identity: 140/644 - (21%)
• Similarity: 225/644 - (34%)
• Gaps: 143/644 - (22%)

  Fly     3 PSPSAGTERQGSSLFLLKSFVRSLRQFLNQTSLHG-LKFVGDSG----LSSWERSFFLGSFVTAL 62
            |.|..|  .|...:.|..||...|..|....::|| ::.|...|    .:|| ....||    ||
Human   203 PPPKEG--HQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSW-GLLSLG----AL 260

  Fly    63 IITVHLISNIYVKWDSTPVIIGISPQATSILKVPFPAITICNMNQVQRSLVANYREGSNESALLK 127
            :.....:..::.:....||::.:|..:...|   .|.:|:|:.|..:.|.|..:         |:
Human   261 VALCWQLGLLFERHWHRPVLMAVSVHSERKL---LPLVTLCDGNPRRPSPVLRH---------LE 313

  Fly   128 LLCESDSWESSEADEEFSASNFVTNNLKISEFVSNHSQ--SCERMLLFCRFSAVERNCSQLFQQI 190
            ||   |.:.....|..::. |.......:|..|..|..  ..:|.:...|.|.........|:..
Human   314 LL---DEFARENIDSLYNV-NLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLC 374

  Fly   191 LTDEGLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESV--------MWDPESGYPE--------- 238
            .:..|.|          .|:.:.:....:.:...|..|        .|:...|..:
Human   375 NSTGGDC----------FYRGYTSGVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSCSY 429

  Fly   239 --------QLPPKFYPA-----------TASGTGITLGFTAVLDAEMGEYYCSSTNGPGFKVYFH 284
                    |.....:|.           ||...|||.|...||..|...:....:...|.:|..|
Human   430 DGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVGLVLRVEQQPHLPLLSTLAGIRVMVH 494

  Fly   285 NPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPAIRS----ISRDGRQCLFKNEKELIFYRIYT 345
            .....|.:.........|.|....|   |.:.|..:.|    .:..|...    |.||:....||
Human   495 GRNHTPFLGHHSFSVRPGTEATISI---REDEVHRLGSPYGHCTAGGEGV----EVELLHNTSYT 552

  Fly   346 RLNCENECLAAFLYDTCSCIPFDHPLIYSNASICSMGDTSCVRRAQRASNRPGW----------- 399
            |..|...|....:.:||||..:.||| .:.|..||            ::..|.|
Human   553 RQACLVSCFQQLMVETCSCGYYLHPL-PAGAEYCS------------SARHPAWGHCFYRLYQDL 604

  Fly   400 --------AKCRQQCLPSCFDLNYLASGFS-FPLA-SNNFQLANALVESF-NKSYLSK-NIAVIN 452
                    ::|.:.|..|.|.   |::|.| :|.| |..:.||....:.. ::|:..: ::|.||
Human   605 ETHRLPCTSRCPRPCRESAFK---LSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKIN 666

  Fly   453 VYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEILYFLILKPLAEL--------- 508
            :.::|..|....:.....:.:.||.:|.:..|:.|.||:||.|:|..|:......|
Human   667 IVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWFGASVLSLLELLELLLDASALTLVLGGRRLRR 731

  Fly   509 --FVWKRSSHVDSEKSLKHNAFGI--EKGQSSDN--PSFWHSKELYPKGV--SISAYEN 559
              |.|.|:|......|:|..|..:  ..|.:||:  ||..|...:...||  .:||.|:
Human   732 AWFSWPRASPASGASSIKPEASQMPPPAGGTSDDPEPSGPHLPRVMLPGVLAGVSAEES 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	ASC	29..499	CDD:459966	112/539 (21%)
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211		3/9 (33%)
		ENaC	219..784	CDD:273304	132/618 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777		11/38 (29%)