Protein Alignment ppk12 and SCNN1B

DIOPT Version :10

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: XP_016879014.1
• Gene: SCNN1B / 6338
• HGNCID: 10600
• Length: 659
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 127/613 - (20%)
• Similarity: 218/613 - (35%)
• Gaps: 167/613 - (27%)

  Fly     9 TERQGSSLFLLKSFVRSLRQ---------------FLNQTSLHGLKFV---GDSGLSSWERSFFL 55
            |...|:::.:.|..::.|.:               :.:.|:.||.|.:   |....:.|   |.|
Human    13 TTLTGATMHVKKYLLKGLHRLQKGPGYTYKELLVWYCDNTNTHGPKRIICEGPKKKAMW---FLL 74

  Fly    56 GSFVTALII-TVHLISNIYVKWD-STPVIIGISPQATSILKVPFPAITICNMNQVQRSLVANYRE 118
            .....||:. ...:....|:.|: |..:.:|..       .:.|||:||||.:..:.|.:.:..:
Human    75 TLLFAALVCWQWGIFIRTYLSWEVSVSLSVGFK-------TMDFPAVTICNASPFKYSKIKHLLK 132

  Fly   119 GSN---ESALLKLLCESDSWESSEADEEFSASNFVTNNLKISE-----------FVSNH------ 163
            ..:   |:.|.::|....|..::..:..||..|. |..:.|.|           |..||
Human   133 DLDELMEAVLERILAPELSHANATRNLNFSIWNH-TPLVLIDERNPHHPMVLDLFGDNHNGLTSS 196

  Fly   164 --------SQSCERMLLFCRFSAVE---RN---------------CSQLFQQILTDE-------G 195
                    :..|:..:..|..:..:   ||               .:.:|.|:...|       |
Human   197 SASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSYPG 261

  Fly   196 ----LCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESG----YPEQLPPKFYPATASGT 252
                |.|:|..:|..|         ||.|:       ::.|..|    :...:..|..|:...||
Human   262 EQMILACLFGAEPCNY---------RNFTS-------IFYPHYGNCYIFNWGMTEKALPSANPGT 310

  Fly   253 GITLGFTAVLDAEMGEYYCSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAV 317
              ..|...:||....:|.....:..|.::..|.....|.:::.|:.:..|.||:..:      .|
Human   311 --EFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGV------LV 367

  Fly   318 PAIRSISRDGRQCLFKNEKELIFYRIYTRLN-------CENECLAAFLYDTCSCIPFDHPLIYSN 375
            ..::.:......|.. |..|:.....|:..|       |...|....:...|:|..:.:||
Human   368 DKLQRMGEPYSPCTV-NGSEVPVQNFYSDYNTTYSIQACLRSCFQDHMIRNCNCGHYLYPL---- 427

  Fly   376 ASICSMGDTSCVRRAQRASNR--PGWAKC----------RQQCL----PSCFDLNY--LASGFSF 422
                ..|:..|       :||  |.||.|          |:.|:    .||.|..|  ..|...:
Human   428 ----PRGEKYC-------NNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADW 481

  Fly   423 PLASNNFQLANALV----ESFNKSYLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMG 483
            |..::...:.:.|.    :|.|.:...|.|..:|:||:|..|....::|...:...|||:||..|
Human   482 PSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFG 546

  Fly   484 LFMGFSVISLAEILYFLILKPLAELFVW 511
            .:||.||:.|.|....:|      .|||
Human   547 FWMGGSVLCLIEFGEIII------DFVW 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	ASC	29..499	CDD:459966	119/564 (21%)
SCNN1B	XP_016879014.1	ENaC	40..642	CDD:273304	123/586 (21%)