Protein Alignment ppk12 and ASIC4

DIOPT Version :9

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_061144.4
• Gene: ASIC4 / 55515
• HGNCID: 21263
• Length: 539
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 119/541 - (21%)
• Similarity: 194/541 - (35%)
• Gaps: 152/541 - (28%)

  Fly    24 RSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVKWDSTPVIIGISPQ 88
            |.|..|.:.::||||......|.....|:.:..:.:|:|...::..:.:...:.:.|.::.:.|.
Human    40 RDLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVAMDPA 104

  Fly    89 ATSILKVPFPAITICNMNQVQRSLVANY---------------REGSNESALLKLLCESDSWESS 138
            |.:.: ..|||:|:||:|:.:.|.:::.               |:|...:.|          ...
Human   105 APAPV-AGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGL----------RYP 158

  Fly   139 EADEEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNCS-QLFQQILTDEGLCCVFNF 202
            |.|              :.:.::........||..|.||.  .:|| ..|..:.|..|.|..||.
Human   159 EPD--------------MVDILNRTGHQLADMLKSCNFSG--HHCSASNFSVVYTRYGKCYTFNA 207

  Fly   203 QPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLDAEMG 267
                                        ||.|..|.:         |.|.|  .|...:||.:..
Human   208 ----------------------------DPRSSLPSR---------AGGMG--SGLEIMLDIQQE 233

  Fly   268 EY--YCSSTN----GPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPAIRSISRD 326
            ||  ....||    ..|.:|..|:..|.|.:.:.|...:.|::|....:..|...:|      :.
Human   234 EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLP------QP 292

  Fly   327 GRQCLFKN---EKELIFYRIYT----RLNCENECLAAFLYDTCSCIPFDHPLIYSNASICSMGDT 384
            ...|..::   |.||..|..|:    ||.||.|.    :...|.|.....|   .|.:||.
Human   293 WGNCRAESELREPELQGYSAYSVSACRLRCEKEA----VLQRCHCRMVHMP---GNETICP---- 346

  Fly   385 SCVRRAQRASNRPG-WAKCRQQCLPS--------CF-----DLNYLASGFSFPLASNNFQLANAL 435
                        |. :.:|....|.|        ||     :|.......|.....|... |..|
Human   347 ------------PNIYIECADHTLDSLGGGPEGPCFCPTPCNLTRYGKEISMVRIPNRGS-ARYL 398

  Fly   436 VESFNK--SYLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEILY 498
            ...:|:  :|:.:|..|::|:|.........:.|..||:..|.::||.||||:|.|:::|.|||.
Human   399 ARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILD 463

  Fly   499 FLI------LKPLAELFVWKR 513
            ::.      ||.     ||:|
Human   464 YIYEVSWDRLKR-----VWRR 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	112/515 (22%)
		ASC	29..499	CDD:279230	112/514 (22%)
ASIC4	NP_061144.4	ASC	40..488	CDD:413546	119/541 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152172
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750