DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk12 and ASIC5

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_059115.1	Gene:	ASIC5 / 51802	HGNCID:	17537	Length:	505	Species:	Homo sapiens

Alignment Length:	581	Identity:	134/581 - (23%)
Similarity:	208/581 - (35%)	Gaps:	193/581 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PSPSAGTERQGSSLFLLKSFVRSLRQFLNQTSLHGLK-----------------FVGDSGLSSWE 50
            |||   |||        |.|.   ..|...||.||:.                 .:|...|.:|:
Human    29 PSP---TER--------KKFD---HDFAISTSFHGIHNIVQNRSKIRRVLWLVVVLGSVSLVTWQ 79

  Fly    51 RSFFLGSFVTALIITVHLISNIYVKWDSTPVIIGISPQATSILKVPFPAITICNMNQVQRSLVAN 115
                         |.:.|::  |..|.:|..|     :...:.|:.|||:|.||:|:.|...||.
Human    80 -------------IYIRLLN--YFTWPTTTSI-----EVQYVEKMEFPAVTFCNLNRFQTDAVAK 124

  Fly   116 YREG------SNESALLKLL-CESDSWESSEADEEFSASNFVTNNLKISEFVSNHSQSCER-MLL 172
            :  |      ...|.:|.|. ..::|..|.|| .:|:||:   .|..|.||:.|....... .||
Human   125 F--GVIFFLWHIVSKVLHLQEITANSTGSREA-TDFAASH---QNFSIVEFIRNKGFYLNNSTLL 183

  Fly   173 FCRFSAVERNCS-QLFQQILTDEGLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGY 236
            .|.|..  :.|| :.|..:.|:.|.|..||                                  :
Human   184 DCEFFG--KPCSPKDFAHVFTEYGNCFTFN----------------------------------H 212

  Fly   237 PEQLPPKFYPATASGTGITLGFTAVLDAEMGEYYCSSTNGP-------GFKVYFHNPIEVPKVKE 294
            .|.|..| ...:.||.|::|.|....:|        .|:.|       |.....|:|.:||:...
Human   213 GETLQAK-RKVSVSGRGLSLLFNVNQEA--------FTDNPALGFVDAGIIFVIHSPKKVPQFDG 268

  Fly   295 AGLISAIGYETNYRIEMVR--------AEAVPAIRSISRDGRQCLFKNEKELIFYRIYTRLNCEN 351
            .||:|.:|......|..|:        .|..|.|:                |..:..|:...|..
Human   269 LGLLSPVGMHARVTIRQVKTVHQEYPWGECNPNIK----------------LQNFSSYSTSGCLK 317

  Fly   352 ECLAAFLYDTCSCIPF---------DHPLIYSNAS----------ICSMGDTSCVRRAQRASNRP 397
            ||.|..:...|.|:||         |....:|..|          :|::|..:
Human   318 ECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHN------------ 370

  Fly   398 GWAKCRQQCLPSCFDLNYLA--SGFSFPLASNNFQLANALVESFNKSYLSKNIAVINVYFRESVY 460
                  ..|..||.::.|.|  |..|||.......|:..|.:|  :.|:.:|:..|.:.:.:..|
Human   371 ------SSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQS--RKYIRENLVKIEINYSDLNY 427

  Fly   461 YGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEILYFL----------ILKPLAELFVW 511
            ....:...|.::|.|:::||.:|||.|.|:|::.||:.:|          .|..::|:..|
Human   428 KITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLLKISEMTQW 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	122/532 (23%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	122/531 (23%)
ASIC5	NP_059115.1	ASC	41..466	CDD:279230	122/531 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3550
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750