DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and ppk21

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_651704.2	Gene:	ppk21 / 43485	FlyBaseID:	FBgn0039675	Length:	550	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	110/543 - (20%)
Similarity:	202/543 - (37%)	Gaps:	115/543 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RQGSSLFLLKSFVRS-LRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYV 74
            |:.|.|..|..|:.. |:.:..::|:||::::.|..:    |::.....:..||:....|..|.|
  Fly    32 RKNSRLGKLWHFMLPYLKDYAAESSVHGIRYLADPKM----RNYLNIRVIWLLILLTTSIGAIVV 92

  Fly    75 KWDSTPVIIGISPQAT------SILKVPFPAITICNMNQVQRSLV----ANYREGSNESA----- 124
            ..|...:...:..|.|      .|.::|||:|.:|..|::...::    .::..|:|.||
  Fly    93 YVDLNELYQTVRIQTTIKNTMLPIFRIPFPSIGLCPRNRLNWKILETEAVDHFLGANVSAAQKDL 157

  Fly   125 LLKLLCESDSWESSEADEEFSASNFVTN-----------NLKISEFVSNHSQSCERMLLFCRFSA 178
            .:|....:.....|..:|   .|||..|           :|.:.|........|:.:...||:..
  Fly   158 FVKFFTAAGDPHLSRLNE---MSNFFGNKTLTDELHMLDHLDLREVYKFIQFRCQDLFHTCRWRG 219

  Fly   179 VERNCSQLFQQILTDEGLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPK 243
            ...||.::.:...|:.|||.|||.:        .:..:|.....|                   |
  Fly   220 NPVNCCEVIEYQFTEAGLCFVFNTE--------ISPASRQKARED-------------------K 257

  Fly   244 FYPATASGTGITLGFTAVLDAEMGEYYCSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYR 308
            :||......|...|....|...      .|...|| |...:..|:.|: :.:.::..:.:|.:.|
  Fly   258 YYPLRTPHYGEGSGLDLFLRLN------RSFIRPG-KRGINVMIKQPQ-QWSDVVRHVPHEAHTR 314

  Fly   309 IEMVRAEAV--PAIRSISRDGRQCLFKNEKELIFYRIYTRL-----NCENECLAAFLYDTCSCIP 366
            |.:.....|  ...|:::.:.|:|:|.:|.:...|:.:...     ||.:.|....:.:.|.|
  Fly   315 ISITPRFTVTDERTRTVTPEIRRCIFGDEVDNPHYKNFPDFEYWVGNCRSRCHQEHVLNLCKC-- 377

  Fly   367 FDHPLIY------SNASICSMGDTSCVR------RAQRASNRPGWAK--------CRQQCLPSCF 411
              .|.|:      .|.:.|...|..|:.      ..:|......:.|        |  .|..||
  Fly   378 --SPSIFFPISDKDNFTACKASDFKCLYDNRFTFSIERHPEEDDFVKNPFKESMIC--DCFTSC- 437

  Fly   412 DLNYLASGFSFPLASNNFQLANALVESFNKSYLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLS 476
                  |...|........|.|      |::........::::::...:.....|......|.|:
  Fly   438 ------SQLVFDRVFTTTTLDN------NETDTEAGTMRLDIFYQSGWFIQYQTNMRFTFVELLA 490

  Fly   477 NVGGVMGLFMGFSVISLAEILYF 499
            :.||::|||:|.|::|..|:.|:
  Fly   491 SFGGIIGLFLGASLLSAFELAYY 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	103/523 (20%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	103/522 (20%)
ppk21	NP_651704.2	ASC	51..513	CDD:279230	103/522 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920