Protein Alignment ppk12 and ASIC1

DIOPT Version :10

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_064423.2
• Gene: ASIC1 / 41
• HGNCID: 100
• Length: 574
• Species: Homo sapiens
• Alignment Length: 651
• Identity: 132/651 - (20%)
• Similarity: 218/651 - (33%)
• Gaps: 229/651 - (35%)

  Fly    25 SLRQFLNQTSLHGLKFVGDSGLSSWERSF----FLGSFVTALIITVHLISNIY-----VKWDSTP 80
            |::.|.:.::||||..:......|.:|:.    ||||....|.:....:...:     .|.|..
Human    17 SIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEV- 80

  Fly    81 VIIGISPQATSILKVPFPAITICNMNQVQRSLVAN---YREGSNESALLKLLCESDSWE---SSE 139
                    |.|  ::.|||:|:||:|:.:.|.|:.   |..|.    ||.||  ::.:|   :..
Human    81 --------AAS--QLTFPAVTLCNLNEFRFSQVSKNDLYHAGE----LLALL--NNRYEIPDTQM 129

  Fly   140 ADE--------EFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNCS-QLFQQILTDEG 195
            |||        :.:..:|......:.||..........|||.|.|..  ..|| :.|:.:.|..|
Human   130 ADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRG--EVCSAEDFKVVFTRYG 192

  Fly   196 LCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTA 260
            .|..||                             ....|.|.....|      .|||  .|...
Human   193 KCYTFN-----------------------------SGRDGRPRLKTMK------GGTG--NGLEI 220

  Fly   261 VLDAEMGEYY------CSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVP- 318
            :||.:..||.      ..::...|.||..|:..|.|.:.:.|...|.|::|....:..|...:|
Human   221 MLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPP 285

  Fly   319 ---AIRSISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSC----IPFDHPLIYSNA 376
               ..::::.|         .:|.|:..|:...|..:|...:|.:.|:|    :|.|.|.
Human   286 PWGTCKAVTMD---------SDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPY----- 336

  Fly   377 SICSMGDTSCVRRAQRASNRPG----------WAKCRQQC-------------LPSCFDLNYLAS 418
                     |.....:....|.          :..|...|             :||.....|||
Human   337 ---------CTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLA- 391

  Fly   419 GFSFPLASNNFQLANALVESFNKS--YLSKNIAVINVYFR----ESVYYGNTKNAYV-------- 469
                              :.||||  |:.:||.|::::|.    |::   ..|.||.
Human   392 ------------------KKFNKSEQYIGENILVLDIFFEVLNYETI---EQKKAYEIAGLLGEL 435

  Fly   470 ------------GLTEF-------------------------LSNVGGVMGLFMGFSVISLAEIL 497
                        |:..:                         |.::||.||||:|.|::::.|:.
Human   436 LMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGDIGGQMGLFIGASILTVLELF 500

  Fly   498 YFLILKPLAELFVWKRSSHVDSEKSLKHNAFGIEKGQS-------SDNPSFWHSKELYPKGVSIS 555
            .:..     |:...|.......:|..|.::  .:||.:       ..||.  .|...:|.|::.:
Human   501 DYAY-----EVIKHKLCRRGKCQKEAKRSS--ADKGVALSLDDVKRHNPC--ESLRGHPAGMTYA 556

  Fly   556 A 556
            |
Human   557 A 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	ASC	29..499	CDD:459966	119/581 (20%)
ASIC1	NP_064423.2	ENaC	19..556	CDD:273304	130/646 (20%)