DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and asic2

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_005164179.1	Gene:	asic2 / 407669	ZFINID:	ZDB-GENE-040513-4	Length:	564	Species:	Danio rerio

Alignment Length:	581	Identity:	137/581 - (23%)
Similarity:	226/581 - (38%)	Gaps:	151/581 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GTERQGSSLFLLKSFVRSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNI 72
            ||.|...|        |.....|::|.||||:.:.....|...|:|::.:|.|.|.:.:...||.
Zfish    54 GTPRDDLS--------RLTVALLSRTRLHGLRHICSPSNSLSRRAFWMIAFCTCLGLLLSWSSNR 110

  Fly    73 YVKWDSTPVIIGISPQATSILKVPFPAITICNMNQVQRSLVAN---YREG-------SNESA--L 125
            .:.|.:.|....:..:...  ::.||.:||||.|.|:...:..   |..|       :|.:|  |
Zfish   111 LLHWLAFPTHTRVHTEWAK--ELAFPTVTICNNNPVRLYHLTKSDLYFAGHWLGLLLANRTARPL 173

  Fly   126 LKLLCESD--SWESSEAD-------EEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVER 181
            :..|.:.|  .|.|..:|       ..|..::.        ||:.......|.|||.|::.. |.
Zfish   174 VLDLLQDDRRGWFSKLSDFRLFLPPRRFEGTSL--------EFMDRLGHQLEDMLLACKYRG-EP 229

  Fly   182 NCSQLFQQILTDEGLCCVFNFQPPEYLYKPFANNNRNL-TNSDGFESVMWDPESGYPEQLPPKFY 245
            ..:..|..:.|..|.|.:||          .|...:.| |...|
Zfish   230 CGAHNFSTVFTRYGKCYMFN----------AAEEGKTLRTTMKG--------------------- 263

  Fly   246 PATASGTGITLGFTAVLDAEMGEYYC------SSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYE 304
                 |||  .|...:||.:..||..      .:....|.:|..|:..|.|.|.|.|...|.|::
Zfish   264 -----GTG--NGLEIMLDIQQDEYLPVWGETEETAFEAGVRVQIHSQAEPPFVHELGFGVAPGFQ 321

  Fly   305 TNYRIEMVRAEAVPAIRSISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSC----I 365
            |....:..|...:|.      ...:|:.:.....:| ::|:...|..||...::.:.|:|    :
Zfish   322 TFVATQEQRLTYLPP------PWGECVSRALDSGLF-QVYSVSACRIECETRYIVENCNCRMVYM 379

  Fly   366 PFDHPLI----YSN------ASICSMGDTSCVRRAQRASNRPGWAKCRQQCLPSCFDLNYLASGF 420
            |.|.|..    |.:      |::.::..|:|:              ||..|..:.:  |...|..
Zfish   380 PGDSPYCTPEQYKDCAEPALAALSAVEGTNCI--------------CRSPCNMTRY--NKELSMV 428

  Fly   421 SFPLASNNFQLANALVESFNKS--YLSKNIAVINVYFRESVYYG--NTKNAY--VGLTEFLSNVG 479
            ..|..::    |..|.:.||:|  |::.||.|::|:| |::.|.  ..|.||  .||   |.::|
Zfish   429 KIPSKTS----ARYLEKKFNRSEKYITDNILVLDVFF-EALNYETIEQKKAYEVAGL---LGDIG 485

  Fly   480 GVMGLFMGFSVISLAEIL---YFLILKPLAELF--VWKRSSH----------VDSEKSLKH 525
            |.||||:|.|:::|.|:.   |.::.:.|.:|.  ..:..||          |:..:|:.|
Zfish   486 GQMGLFIGASILTLLELFDYAYEVVKERLLDLLNREEEEESHGEDVSTCDPVVNHSESISH 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	124/521 (24%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	124/520 (24%)
asic2	XP_005164179.1	ASC	71..538	CDD:295594	128/546 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586626
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.900