Protein Alignment ppk12 and asic4b

DIOPT Version :10

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_999951.1
• Gene: asic4b / 407667
• ZFINID: ZDB-GENE-040513-6
• Length: 558
• Species: Danio rerio
• Alignment Length: 575
• Identity: 128/575 - (22%)
• Similarity: 213/575 - (37%)
• Gaps: 153/575 - (26%)

  Fly     2 EPSPSAGTERQGSSLF-----LLKSFVRSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVT- 60
            |.:..|.||..|:.:.     ..|..:..|..|.:.:|||||.    ..|.:.||   ||...|
Zfish    15 EEAKGASTEGGGTGMLDEGLRRQKEGMADLASFASSSSLHGLA----RALGTSER---LGFRQTL 72

  Fly    61 ---ALIITVHLISNIY-VKWDST-----PVIIGISPQATSILKVPFPAITICNMNQVQRSL---- 112
               ||::::.|.  :| ..|.:.     |.:..:..:...  ::.|||||:||:|:.:.|.
Zfish    73 WGLALLVSLGLF--LYQATWSAATYLERPHLAALREETRR--ELTFPAITLCNVNRFRFSALTDA 133

  Fly   113 ----VANY-------REGSNESALLKLLCESDSWESSEADEEFSASNFVTNNLKISEFVSNHSQS 166
                :||.       |:|...|.|                 ::...|.:       :........
Zfish   134 DIYHLANLTGLPPKSRKGHRPSEL-----------------QYPPPNML-------DIFQRTGHQ 174

  Fly   167 CERMLLFCRFSAVERNC-SQLFQQILTDEGLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMW 230
            .|.||..|.||.  :|| |:.|..:.|..|.|..|               |.|.|:
Zfish   175 LEDMLKSCNFSG--QNCSSEDFSVVYTRYGKCYTF---------------NGNKTS--------- 213

  Fly   231 DPESGYPEQLPPKFYPATASGTGITLGFTAVLDAEMGEYY------CSSTNGPGFKVYFHNPIEV 289
                       ||......:|.|:.:    :||.:..||.      ..:|...|.:|..|:..|.
Zfish   214 -----------PKRVRQGGTGNGLEM----MLDIQQDEYLPIWRETNETTLEAGIRVQIHSQNEP 263

  Fly   290 PKVKEAGLISAIGYETNYRIEMVRAEAVPAIRSISRDGRQCLFKNEKELIFYRIYTRLNCENECL 354
            |.:.:.|...:.|::|....:..|...:|      :....|...:|..:..|..|:...|...|.
Zfish   264 PYIHQLGFGVSPGFQTFVSCQEQRLTYLP------QPWGNCRASSEPVIPGYDTYSVSACRLHCE 322

  Fly   355 AAFLYDTCSCIPFDHPLIYSNASICSMGDTSCVRRAQRASNRPGWAKCRQQCLPSCFDLNY--LA 417
            :..:...|:|.....|   .:|.||:.....||.:|..:..:.....|  .|...|....|  ..
Zfish   323 STQVQRECNCRMVHMP---GDADICAPSKIKCVDKALASLQKSTGDSC--PCETPCNLTRYGKEL 382

  Fly   418 SGFSFPLASNNFQLANALVESFNKS--YLSKNIAVINVYFRESVYYG--NTKNAYVGLTEFLSNV 478
            |....|...:    |..|...:.||  |:..|..:::::| |::.|.  ..|.|| .:...|.::
Zfish   383 SMVKIPSRGS----ARYLSRKYQKSEEYIRDNFLILDIFF-EALNYETIEQKKAY-DIAGLLGDI 441

  Fly   479 GGVMGLFMGFSVISLAEILYFL----------ILKPLAELFVWKRSSHVDSEKSL 523
            ||.||||:|.|::::.|||.::          :|||       |:|....::::|
Zfish   442 GGQMGLFIGASILTILEILDYIYEVAKNKIKQLLKP-------KKSQKQTNQRNL 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	ASC	29..499	CDD:459966	115/507 (23%)
asic4b	NP_999951.1	ENaC	54..497	CDD:273304	118/536 (22%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	450..452		1/1 (100%)