Protein Alignment ppk12 and ASIC2

DIOPT Version :10

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_899233.1
• Gene: ASIC2 / 40
• HGNCID: 99
• Length: 563
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 137/571 - (23%)
• Similarity: 221/571 - (38%)
• Gaps: 144/571 - (25%)

  Fly     2 EPSPSA-------GTERQGSSLFLLKSFVRSLRQFLNQTSLHGLKFV----GDSGLSSWERSFFL 55
            ||:|:|       |..|.|..........|..|..|::..||||:.:    ..:|.|...|:.::
Human    26 EPAPAALAAAGQPGGGRGGERALQGPGVARRGRPSLSRAKLHGLRHMCAGRTAAGGSFQRRALWV 90

  Fly    56 GSFVTALIITVHLISNIYVKWDSTPVIIGIS-PQATSI-----LKVPFPAITICNMNQVQRSLVA 114
            .:|.|:.        .:.:.|.|..::..:| |..|.:     .::||||:|:||.|.::...::
Human    91 LAFCTSF--------GLLLSWSSNRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLS 147

  Fly   115 N---YREG-------SNESA--LLKLLCESD----SWESSEAD----------EEFSASNFVTNN 153
            .   |..|       .|.:|  |:..|...|    .|....||          |..||:
Human   148 KGDLYYAGHWLGLLLPNRTARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAA------ 206

  Fly   154 LKISEFVSNHSQSCERMLLFCRFSAVERNCSQLFQQILTDEGLCCVFNFQPPEYLYKPFANNNRN 218
                 |:.......|.|||.|::.. |......|..:.|..|.|.:||
Human   207 -----FMDRLGHQLEDMLLSCKYRG-ELCGPHNFSSVFTKYGKCYMFN----------------- 248

  Fly   219 LTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLDAEMGEYYC------SSTNGP 277
                        ..|.|.|      .......|||  .|...:||.:..||..      .:|...
Human   249 ------------SGEDGKP------LLTTVKGGTG--NGLEIMLDIQQDEYLPIWGETEETTFEA 293

  Fly   278 GFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPAIRSISRDGRQCLFKNEKELIFYR 342
            |.||..|:..|.|.::|.|...|.|::|....:..|...:|......|       .:|..|.|:.
Human   294 GVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECR-------SSEMGLDFFP 351

  Fly   343 IYTRLNCENECLAAFLYDTCSC--------IPFDHPLIYSNASICSMGDTSCVRRAQRASNRPGW 399
            :|:...|..:|...::.:.|:|        .||..|..:...:..::|     ..|::.||   :
Human   352 VYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALG-----LLAEKDSN---Y 408

  Fly   400 AKCRQQCLPSCFDLNYLASGFSFPLASNNFQLANALVESFNKS--YLSKNIAVINVYFRESVYYG 462
            ..||..|  :....|...|....|..::    |..|.:.||||  |:|:||.|::::| |::.|.
Human   409 CLCRTPC--NLTRYNKELSMVKIPSKTS----AKYLEKKFNKSEKYISENILVLDIFF-EALNYE 466

  Fly   463 --NTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEI---LYFLILKPLAEL 508
              ..|.|| .:...|.::||.||||:|.|::::.|:   :|.||.:.|.:|
Human   467 TIEQKKAY-EVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDL 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	ASC	29..499	CDD:459966	123/526 (23%)
ASIC2	NP_899233.1	ENaC	64..547	CDD:273304	127/533 (24%)