DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and scnn1a

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_001184124.1	Gene:	scnn1a / 395013	XenbaseID:	XB-GENE-996083	Length:	633	Species:	Xenopus tropicalis

Alignment Length:	633	Identity:	129/633 - (20%)
Similarity:	221/633 - (34%)	Gaps:	194/633 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LKSFVRSLRQ----FLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVKWDST 79
            |..|..|.|:    |.:.|::||...:..|..:..:.:|:|..|:....:.......::.::.|.
Frog    12 LIEFFSSYRELFEFFCSNTTIHGAIRLVCSRSNRMKTAFWLVLFLATFGLMYWQFGLLFGQYFSY 76

  Fly    80 PVIIGISPQATSILKVPFPAITICNMN----------------QVQRSLVANYREGS-------- 120
            ||.|.::..:.   |:||||:|:|.:|                :.||:|...|:..|
Frog    77 PVSINLNVNSD---KLPFPAVTVCTLNPYRYKAIQNDLQELDKETQRTLYELYKYNSTGVQGWIP 138

  Fly   121 -NESA---------LLKLL--------------------------------------CESDSWES 137
             |:..         ||:|:                                      |...::.|
Frog   139 TNQRVRRDRPGLPHLLELVPPGSKTHRVSRSVIEEELQVKRREWNIGFKLCNETGGDCFYQTYTS 203

  Fly   138 S-EADEEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRF---SAVERNCSQLFQQILTDEGLCC 198
            . :|..|:...:::....::.|..:...:..|..:..|||   |..:.|.|.....|.   |.|.
Frog   204 GVDAIREWYRFHYINILARVPEEAAIDGEQLENFIFACRFNEESCTKANYSHFHHAIY---GNCY 265

  Fly   199 VFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLD 263
            .||                  .|..| :|.:|                 ::|..||..|.|.:|.
Frog   266 TFN------------------QNRSG-QSNLW-----------------SSSMPGIKNGLTLILR 294

  Fly   264 AEMGEYYCSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPAI----RSIS 324
            .|..:|....::..|.:|..|...|...:.::|.....|.||:..   ::.|.|..:    ...|
Frog   295 TEQHDYIPLLSSVAGARVLVHGHKEPAFMDDSGFNIPPGMETSIG---MKKETVNRMGGKYSDCS 356

  Fly   325 RDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSCIPFDHPLIYSNASICSMGDTSCVRR 389
            .||.....||    :|...||...|...|..|.:.:.|.|....:||        |.||..|...
Frog   357 EDGSDVDVKN----LFESEYTEQVCVRSCFQAAMVERCGCGYAFYPL--------SPGDEFCDYN 409

  Fly   390 AQRA-------------SNRPG-WAKCRQQCLPSCFDL--------NYLASGFSFPLASNNFQLA 432
            ..::             ||:.| ::|||:.||.|.:.|        |.::..:.|...|..:.|.
Frog   410 KHKSWGHCYYKLIIEFTSNKLGCFSKCRKPCLVSEYQLTAGYSKWPNRVSQDWVFHTLSRQYNLT 474

  Fly   433 NALVESFNKSYLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEI- 496
            :           ...||.:|:||.|..|....::..:.:...||.:|....|:.|.||:|:.|:
Frog   475 D-----------RNGIAKLNIYFEELNYKTIQESPTINMVMLLSLLGSQWSLWFGSSVLSVVEML 528

  Fly   497 -----LYFLILKPLAELFVWKRS--------------SHVDSEKSLKH 525
                 |..::|..|...:.:|::              |..|.|:.:.|
Frog   529 ELVIDLVIIVLIMLFHRYYYKQADEGEATSAVPTPAPSFADLEQQVPH 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	118/582 (20%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	118/577 (20%)
scnn1a	NP_001184124.1	ENaC	18..602	CDD:273304	127/627 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5830
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	117	1.000	Inparanoid score	I4647
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48391
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060