Protein Alignment ppk12 and scnn1a

DIOPT Version :10

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_001184124.1
• Gene: scnn1a / 395013
• XenbaseID: XB-GENE-996083
• Length: 633
• Species: Xenopus tropicalis
• Alignment Length: 633
• Identity: 129/633 - (20%)
• Similarity: 221/633 - (34%)
• Gaps: 194/633 - (30%)

  Fly    19 LKSFVRSLRQ----FLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVKWDST 79
            |..|..|.|:    |.:.|::||...:..|..:..:.:|:|..|:....:.......::.::.|.
 Frog    12 LIEFFSSYRELFEFFCSNTTIHGAIRLVCSRSNRMKTAFWLVLFLATFGLMYWQFGLLFGQYFSY 76

  Fly    80 PVIIGISPQATSILKVPFPAITICNMN----------------QVQRSLVANYREGS-------- 120
            ||.|.::..:.   |:||||:|:|.:|                :.||:|...|:..|
 Frog    77 PVSINLNVNSD---KLPFPAVTVCTLNPYRYKAIQNDLQELDKETQRTLYELYKYNSTGVQGWIP 138

  Fly   121 -NESA---------LLKLL--------------------------------------CESDSWES 137
             |:..         ||:|:                                      |...::.|
 Frog   139 TNQRVRRDRPGLPHLLELVPPGSKTHRVSRSVIEEELQVKRREWNIGFKLCNETGGDCFYQTYTS 203

  Fly   138 S-EADEEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRF---SAVERNCSQLFQQILTDEGLCC 198
            . :|..|:...:::....::.|..:...:..|..:..|||   |..:.|.|.....|.   |.|.
 Frog   204 GVDAIREWYRFHYINILARVPEEAAIDGEQLENFIFACRFNEESCTKANYSHFHHAIY---GNCY 265

  Fly   199 VFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLD 263
            .||                  .|..| :|.:|                 ::|..||..|.|.:|.
 Frog   266 TFN------------------QNRSG-QSNLW-----------------SSSMPGIKNGLTLILR 294

  Fly   264 AEMGEYYCSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPAI----RSIS 324
            .|..:|....::..|.:|..|...|...:.::|.....|.||:..   ::.|.|..:    ...|
 Frog   295 TEQHDYIPLLSSVAGARVLVHGHKEPAFMDDSGFNIPPGMETSIG---MKKETVNRMGGKYSDCS 356

  Fly   325 RDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSCIPFDHPLIYSNASICSMGDTSCVRR 389
            .||.....||    :|...||...|...|..|.:.:.|.|....:||        |.||..|...
 Frog   357 EDGSDVDVKN----LFESEYTEQVCVRSCFQAAMVERCGCGYAFYPL--------SPGDEFCDYN 409

  Fly   390 AQRA-------------SNRPG-WAKCRQQCLPSCFDL--------NYLASGFSFPLASNNFQLA 432
            ..::             ||:.| ::|||:.||.|.:.|        |.::..:.|...|..:.|.
 Frog   410 KHKSWGHCYYKLIIEFTSNKLGCFSKCRKPCLVSEYQLTAGYSKWPNRVSQDWVFHTLSRQYNLT 474

  Fly   433 NALVESFNKSYLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEI- 496
            :           ...||.:|:||.|..|....::..:.:...||.:|....|:.|.||:|:.|:
 Frog   475 D-----------RNGIAKLNIYFEELNYKTIQESPTINMVMLLSLLGSQWSLWFGSSVLSVVEML 528

  Fly   497 -----LYFLILKPLAELFVWKRS--------------SHVDSEKSLKH 525
                 |..::|..|...:.:|::              |..|.|:.:.|
 Frog   529 ELVIDLVIIVLIMLFHRYYYKQADEGEATSAVPTPAPSFADLEQQVPH 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	ASC	29..499	CDD:459966	118/577 (20%)
scnn1a	NP_001184124.1	ENaC	18..602	CDD:273304	127/627 (20%)