DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and ppk26

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_648125.3	Gene:	ppk26 / 38835	FlyBaseID:	FBgn0035785	Length:	597	Species:	Drosophila melanogaster

Alignment Length:	579	Identity:	145/579 - (25%)
Similarity:	265/579 - (45%)	Gaps:	95/579 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TERQ---GSSLFLLKSFVRSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLIS 70
            |::|   ||.....|:.:   .::.:.|::||::::|:......||.|::...|.::...|.|..
  Fly    54 TKKQIKYGSGFQAAKAII---HEYCDYTTIHGIRYLGEKKRPLLERLFWISVLVLSVFTCVKLTL 115

  Fly    71 NIYVKWDSTPVIIGISPQATSILKVPFPAITICNMNQVQRSLVANYREG--------SNESALLK 127
            ||:.||::.|||:..:.::|.:.::||||:|:|...:.:|. :.|:.:.        ||.|.::.
  Fly   116 NIWDKWNNNPVIVSFAEKSTPVWQIPFPAVTVCPETKTRRE-IFNFTDSYHQVRDFQSNVSGIVD 179

  Fly   128 LLCESDSWES-----SEADE----EFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNC 183
            |   ||..:.     |:..|    :.:..|.....::|.:.::..|...:...|.|::......|
  Fly   180 L---SDKQKGLYGAVSQVCEPHLHDVTLGNKTRRGMEIIDALTEVSPHFDDTYLNCKWRNSPVKC 241

  Fly   184 SQLFQQILTDEGLCCVFNFQPPEYLYKP--------FANNNRNLTNSDGFESVMWDPESGYPEQL 240
            |.:|.:.:|::|:|..||...|..:::.        |...||        .|:.|:.|.||....
  Fly   242 SDIFHKFVTEDGVCFSFNSLSPAEIFRAEGIIPDFIFREENR--------LSMDWNVEDGYSASA 298

  Fly   241 PPKFYPATASGTGITLGFTAVL-DAEMGEYYCSSTNGP--GFKVYFHNPIEVPKVKEAGLISAIG 302
            ....||....|.|...|....: .||:.  :.....||  |||:..|.|.:|.:|.
  Fly   299 DTSPYPNRVLGPGARAGLYLFMGGAEID--FDDMCRGPVQGFKILLHTPGDVAQVS--------- 352

  Fly   303 YETNYRIEMVRAEAVPAIRS---ISRDG--------RQCLFKNEKELIFYRIYTRLNCENECLAA 356
             :..:||...: |.:.:||.   .:.||        |||.|:.|:||.::.||::.|||.||||.
  Fly   353 -KQYFRIPFDQ-EVLISIRPKIITTSDGLKHYEPNRRQCYFQKERELRYFNIYSQSNCELECLAN 415

  Fly   357 FLYDTCSCIPFDHPLIYSNASICSMGDTSCVRRAQ--------------RASNRPGWAKCRQQCL 407
            |....|.|:.|..|. ..|..:|......|..:|:              ...|..|..:|  .||
  Fly   416 FTLTKCGCVKFSMPR-NVNMPVCGDASLKCYNQAEDELLLREFTQGLVNAGENTRGETEC--NCL 477

  Fly   408 PSCFDLNYLA----SGFSFPLASNNFQLANALVESFNKSYLSKNIAVINVYFRESVYYGNTKNAY 468
            |||..:.|.|    :.|.:....|.........:|..:   ...::.::::|:|:.:..:.::..
  Fly   478 PSCTSIAYEAEISQADFDYKTVINTDSPEGKEEQSKRQ---GMKMSRVSIFFKEAQFLTSRRSEL 539

  Fly   469 VGLTEFLSNVGGVMGLFMGFSVISLAEILYFLILKPLAELFVWKRSSHVDSEKSLKHNA 527
            .|.|:||:|.||::|||||.|::|:.|::||..::.::.|.: :|.:..:..|::..:|
  Fly   540 YGTTDFLANCGGLLGLFMGVSMLSIVELIYFCTVRLISNLRM-RRKTRKELLKAVNKDA 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	134/527 (25%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	134/526 (25%)
ppk26	NP_648125.3	ASC	74..570	CDD:279230	134/526 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456756
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	1	1.000	-	-		otm24766
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
	10	9.900