DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and ppk17

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_001285988.1	Gene:	ppk17 / 35006	FlyBaseID:	FBgn0032602	Length:	431	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	105/551 - (19%)
Similarity:	174/551 - (31%)	Gaps:	195/551 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 FLGSFVTALIITVHLISNIYVKWDSTPVIIGISPQATSILK--VPFPAITICNMNQVQRSLVANY 116
            :|..|...:::.|.|. ..:.|..:.|    ||..:...|.  :..|::|||.....:..::...
  Fly    21 YLVLFACCIVVIVQLY-ECFAKLYNPP----ISTHSYYSLNETIEMPSVTICREPPYKEEVLTRL 80

  Fly   117 REGSNESALLKLLCESDSWESSEADEEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSA--- 178
            ..|:         |....:.:......|       ..:.:.||..|.:.......:|...:.
  Fly    81 SGGA---------CPHPKYATCWMKYPF-------GEISLDEFFENSTHDSGDTFVFYGLNEDKN 129

  Fly   179 -VERNCSQLFQQILTDEGLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPP 242
             |..|.|..|..     |.|  :..:|.|        :.:.::.:.|: |:|.:.
  Fly   130 NVVMNSSLHFYM-----GRC--YTLRPKE--------SAKRVSKAVGY-SIMLEH---------- 168

  Fly   243 KFYPATASGTGITLGFTAVLDAEMGEYYCSSTNGPGFKVYFH----NPIEVPKVKEAGLISAIGY 303
                        ::..|:|.|.:.|..        |:.|:.|    |..|: .:|.:|.:..:..
  Fly   169 ------------SMLTTSVSDVDTGSV--------GWHVFIHDKKENFTEI-NMKGSGRVEYVFV 212

  Fly   304 ETNYRIEM-----------VRAEAVPAIRSISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAF 357
            ..|..||:           .|.||      .|.|..               |:.|.|..:|:...
  Fly   213 GVNEEIEIKLQTQYFSNVQTREEA------CSDDEN---------------YSDLKCGEQCIWQD 256

  Fly   358 LYDTCSCI-PFDHPL--------------------IYSNASICSMGDTSCVRRAQRASNRPGWAK 401
            |.|...|. |:.|.:                    :|.|..     |..|              .
  Fly   257 LADNMQCSGPWMHEIASEPCNDSLSMRKLISDYKDVYENED-----DFDC--------------D 302

  Fly   402 CRQQC---LPSCFDLNYLASGFSFPLASNNFQLANALVESFNKSYLSKNIAVINVYFRESVYYGN 463
            |.|.|   :.:.|..|..|  |:.|.......:          .|.:|.|::|    .|...|..
  Fly   303 CVQPCQSRIYTTFIQNRKA--FNQPEPRTQIYI----------YYTTKLISMI----EERPSYDT 351

  Fly   464 TKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEILYFLILKPLAELFVW---KRSSHVDSEKSLKH 525
                    |:|:::|||.:|..:|.||:.|..||..::|     .|..   ||....:..| |:.
  Fly   352 --------TQFIADVGGSLGFLLGLSVLGLIGILEHMML-----FFCGGFIKRMQQKEQAK-LEA 402

  Fly   526 NAFGIEKGQSS------DNPSFWHSKELYPK 550
            |:   |.|||.      |....:..||..||
  Fly   403 NS---EDGQSQTSDETIDVEIAYKKKEKQPK 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	89/489 (18%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	89/489 (18%)
ppk17	NP_001285988.1	ASC	11..358	CDD:295594	79/468 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456728
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11690
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930