DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and ppk28

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_573169.2	Gene:	ppk28 / 32671	FlyBaseID:	FBgn0030795	Length:	606	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	196/560 - (35%)
Similarity:	294/560 - (52%)	Gaps:	51/560 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SPSAGTERQGSS------LFLLKSFVRSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTAL 62
            |.|:|.::...|      :....:..||:..:|..::|||||::.:..::..||.||..:||..:
  Fly    12 SGSSGCKKDSESDDDENTICSRAAIKRSVVYYLKNSTLHGLKYIAEESITIPERIFFGLAFVLVV 76

  Fly    63 IITVHLISNIYVKWDSTPVIIGISPQATSILKVPFPAITICNMNQVQRSLVANYREGSNESALLK 127
            |::|..|||:||||.::|:||..|.:......:|||||||||:||...|.|......|...:||.
  Fly    77 ILSVFFISNVYVKWSASPIIISTSAKQKLTSNMPFPAITICNLNQALLSKVDRIGRTSTNFSLLM 141

  Fly   128 LLCES---------DSWESSEADEEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNC 183
            .||:.         .:|:..:|                  .:.:.:|.||:|||:|.|.:.|.:|
  Fly   142 GLCDQGGDTTISYIGTWKYFKA------------------ILVDVAQPCEKMLLYCSFGSREEDC 188

  Fly   184 SQLFQQILTDEGLCCVFNFQPPEYLYKPFANNNRNLT--NSDGFESVMWDPESGYPEQLPPKFYP 246
            |.||..||||:||||.||...|.||.:.::::.|..|  .:..:|.:.|.||.||...||..::|
  Fly   189 SWLFTSILTDDGLCCNFNALHPSYLIRNYSDDVRLETAHPNTRYELIDWTPEKGYARNLPEFYFP 253

  Fly   247 ATASGTGITLGFTAVLDAEMGEYYCSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEM 311
            .|:.||||.:|.|.||:|.:.||||:.:...||||..|||.|:|||...|.:...|.|....||.
  Fly   254 RTSGGTGIRMGLTVVLNASIAEYYCTKSMSVGFKVLVHNPAELPKVSNYGFVVTAGREARIPIEP 318

  Fly   312 VRAEAVPAIRSISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSCIPFDHPLIYSNA 376
            |..:|:|.||||.:..|:|||.:|.:|.:||.|:|.|||.||.|..|...|||:.:..|.|...|
  Fly   319 VYEDALPTIRSIKKSVRRCLFSDENDLAYYRTYSRKNCELECEAKLLLRECSCVLYYLPRIDPLA 383

  Fly   377 SICSMGDTSCVRRAQRASNRPGWAKCRQQCLPSCFDLNYLASGFSFPLASN-NFQLANALVE-SF 439
            .:|...|..|..|.|............:.|.|.||:|.|.|:..:..:.|: .||....|.| .|
  Fly   384 RVCGPNDNQCTDRVQTEIESSLTNLSCENCWPGCFELTYRATLSTASIVSDPRFQAGENLPEYIF 448

  Fly   440 NKSYL-SKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEILYFLILK 503
            :..|. :..|::::.|:..:::...||:...|.||||||.||::|||||||:.|:.||.:::.::
  Fly   449 HGPYSNASEISILHFYYMTNIFRSTTKSEMFGFTEFLSNTGGLLGLFMGFSIFSVIEIFFYITVR 513

  Fly   504 PLA-------------ELFVWKRSSHVDSEKSLKHNAFGI 530
            |..             |...|.....:...::|:.|..|:
  Fly   514 PYCASRTLRQRHKRRLEQLSWLTPIRMPVRRALRRNRGGL 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	184/484 (38%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	184/483 (38%)
ppk28	NP_573169.2	ASC	43..509	CDD:279230	184/483 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469311
Domainoid	1	1.000	101	1.000	Domainoid score	I6864
eggNOG	1	0.900	-	-		E1_KOG4294
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I4956
Isobase	1	0.950	-	0	Normalized mean entropy	S7217
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112386at6656
OrthoFinder	1	1.000	-	-		FOG0000867
OrthoInspector	1	1.000	-	-		otm24766
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	P	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
	12	11.750