Protein Alignment ppk12 and Scnn1a

DIOPT Version :10

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_113736.1
• Gene: Scnn1a / 25122
• RGDID: 3639
• Length: 699
• Species: Rattus norvegicus
• Alignment Length: 613
• Identity: 118/613 - (19%)
• Similarity: 224/613 - (36%)
• Gaps: 150/613 - (24%)

  Fly     2 EPS-PSAGTERQGSSLFLLKSFVRSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIIT 65
            ||| |...||.:.:.:...:|:....:.|.|.|::||...:..|..:..:.:|:...::....:.
  Rat    60 EPSAPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMM 124

  Fly    66 VHLISNIYVKWDSTPVIIGISPQATSILKVPFPAITICNMNQVQRSLVANYREGSNESALLKLLC 130
            ....:.::.::.|.||.:.|:..:.   |:.|||:|:|.:|..:      |.|...|...|..:.
  Rat   125 YWQFALLFEEYLSYPVSLNINLNSD---KLVFPAVTVCTLNPYR------YTEIKEELEELDRIT 180

  Fly   131 ESDSWESSEADEEFS---------------------------------------ASNFVTNNLKI 156
            |...::..:.:..::                                       :|:...||.::
  Rat   181 EQTLFDLYKYNSSYTRQAGARRRSSRDLLGAFPHPLQRLRTPPPPYSGRTARSGSSSVRDNNPQV 245

  Fly   157 SE-----------------FVSNHSQSCERMLLFCRF------SAVERNCSQLFQQILTDEGLCC 198
            ..                 |...:|...:.:..:.||      |.:......|.::.|.:....|
  Rat   246 DRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLSDTSPALEEEALGNFIFTC 310

  Fly   199 VFNFQP------PEYLYKPFAN----NNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTG 253
            .||..|      .::.:..:.|    |::|.:|       :|                 .:|..|
  Rat   311 RFNQAPCNQANYSKFHHPMYGNCYTFNDKNNSN-------LW-----------------MSSMPG 351

  Fly   254 ITLGFTAVLDAEMGEYYCSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVP 318
            :..|.:..|..|..::....:...|.:|..|...|...:.:.|.....|.||:  |.| |.||:.
  Rat   352 VNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETS--ISM-RKEALD 413

  Fly   319 AI----RSISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSCIPFDHPLIYSNASIC 379
            ::    ...:.:|.....||    ::...||:..|.:.|....:...|.|....:|. ......|
  Rat   414 SLGGNYGDCTENGSDVPVKN----LYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPK-PKGVEFC 473

  Fly   380 SMGDTS----CVRRAQRASNRPGWAKCRQQCLPSCFDLNY-LASGFS-----------FPLAS-- 426
            .....|    |..:.|.|.:..... |..:|...|..:|| |::|:|           |.:.|
  Rat   474 DYRKQSSWGYCYYKLQGAFSLDSLG-CFSKCRKPCSVINYKLSAGYSRWPSVKSQDWIFEMLSLQ 537

  Fly   427 NNFQLANALVESFNKSYLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVI 491
            ||:.:.|.          ...:|.:|::|:|..|..|:::..|.:...|||:|....|:.|.||:
  Rat   538 NNYTINNK----------RNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVL 592

  Fly   492 S---LAEILYFLILKPLAELFVWKRSSH 516
            |   :||:::.|::..|..|....||.:
  Rat   593 SVVEMAELIFDLLVITLLMLLRRFRSRY 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	ASC	29..499	CDD:459966	106/566 (19%)
Scnn1a	NP_113736.1	ENaC	80..677	CDD:273304	112/593 (19%)