DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and Scnn1a

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_113736.1	Gene:	Scnn1a / 25122	RGDID:	3639	Length:	699	Species:	Rattus norvegicus

Alignment Length:	613	Identity:	118/613 - (19%)
Similarity:	224/613 - (36%)	Gaps:	150/613 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EPS-PSAGTERQGSSLFLLKSFVRSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIIT 65
            ||| |...||.:.:.:...:|:....:.|.|.|::||...:..|..:..:.:|:...::....:.
  Rat    60 EPSAPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMM 124

  Fly    66 VHLISNIYVKWDSTPVIIGISPQATSILKVPFPAITICNMNQVQRSLVANYREGSNESALLKLLC 130
            ....:.::.::.|.||.:.|:..:.   |:.|||:|:|.:|..:      |.|...|...|..:.
  Rat   125 YWQFALLFEEYLSYPVSLNINLNSD---KLVFPAVTVCTLNPYR------YTEIKEELEELDRIT 180

  Fly   131 ESDSWESSEADEEFS---------------------------------------ASNFVTNNLKI 156
            |...::..:.:..::                                       :|:...||.::
  Rat   181 EQTLFDLYKYNSSYTRQAGARRRSSRDLLGAFPHPLQRLRTPPPPYSGRTARSGSSSVRDNNPQV 245

  Fly   157 SE-----------------FVSNHSQSCERMLLFCRF------SAVERNCSQLFQQILTDEGLCC 198
            ..                 |...:|...:.:..:.||      |.:......|.::.|.:....|
  Rat   246 DRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLSDTSPALEEEALGNFIFTC 310

  Fly   199 VFNFQP------PEYLYKPFAN----NNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTG 253
            .||..|      .::.:..:.|    |::|.:|       :|                 .:|..|
  Rat   311 RFNQAPCNQANYSKFHHPMYGNCYTFNDKNNSN-------LW-----------------MSSMPG 351

  Fly   254 ITLGFTAVLDAEMGEYYCSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVP 318
            :..|.:..|..|..::....:...|.:|..|...|...:.:.|.....|.||:  |.| |.||:.
  Rat   352 VNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETS--ISM-RKEALD 413

  Fly   319 AI----RSISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSCIPFDHPLIYSNASIC 379
            ::    ...:.:|.....||    ::...||:..|.:.|....:...|.|....:|. ......|
  Rat   414 SLGGNYGDCTENGSDVPVKN----LYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPK-PKGVEFC 473

  Fly   380 SMGDTS----CVRRAQRASNRPGWAKCRQQCLPSCFDLNY-LASGFS-----------FPLAS-- 426
            .....|    |..:.|.|.:..... |..:|...|..:|| |::|:|           |.:.|
  Rat   474 DYRKQSSWGYCYYKLQGAFSLDSLG-CFSKCRKPCSVINYKLSAGYSRWPSVKSQDWIFEMLSLQ 537

  Fly   427 NNFQLANALVESFNKSYLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVI 491
            ||:.:.|.          ...:|.:|::|:|..|..|:::..|.:...|||:|....|:.|.||:
  Rat   538 NNYTINNK----------RNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVL 592

  Fly   492 S---LAEILYFLILKPLAELFVWKRSSH 516
            |   :||:::.|::..|..|....||.:
  Rat   593 SVVEMAELIFDLLVITLLMLLRRFRSRY 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	106/567 (19%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	106/566 (19%)
Scnn1a	NP_113736.1	ENaC	80..677	CDD:273304	112/593 (19%)
Scnn1a	NP_113736.1	deg-1	88..600	CDD:273309	105/563 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345675
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4773
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.800