DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and Scnn1g

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_058742.2	Gene:	Scnn1g / 24768	RGDID:	3641	Length:	650	Species:	Rattus norvegicus

Alignment Length:	613	Identity:	112/613 - (18%)
Similarity:	199/613 - (32%)	Gaps:	157/613 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVKWDSTPVIIGISPQATSI----L 93
            |:.||.:.:..| .....|..::...:||:.:.:         |....::......:.||    .
  Rat    36 TNTHGCRRIVVS-RGRLRRLLWIAFTLTAVALII---------WQCALLVFSFYTVSVSIKVHFQ 90

  Fly    94 KVPFPAITICNMNQVQRSLVANY---REGSNESALLKLLCESDSWESSEA--------------- 140
            |:.|||:||||:|..:.|.|::.   .:...:.|||.|....:|.:..||
  Rat    91 KLDFPAVTICNINPYKYSAVSDLLTDLDSETKQALLSLYGVKESRKRREAGSMPSTLEGTPPRFF 155

  Fly   141 ----------DEEFSASNFVT-NNLKIS----------------------EFVSNHSQSCERMLL 172
                      :|:..|.:|.| ...|||                      :..||.:..|.....
  Rat   156 KLIPLLVFNENEKGKARDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTF 220

  Fly   173 FCRFSAVER-------------------NCSQLFQQILTD---EGLCCVFN----FQPPEYLYKP 211
            ....:|::.                   |.|...:::|..   :|:.|...    |..|.|....
  Rat   221 SSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAKELLVTCFFDGMSCDARNFTLFHHPMYGNCY 285

  Fly   212 FANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLDAEMGEYYCSSTNG 276
            ..||..|.|                        ..:|:.| |...|...:|.....||.....:.
  Rat   286 TFNNKENAT------------------------ILSTSMG-GSEYGLQVILYINEDEYNPFLVSS 325

  Fly   277 PGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRA-EAVPAIRSISRDGRQCLFKNEKELIF 340
            .|.||..|...|.|.:::.|:.......|:..:.:..: :........:.||......|    |:
  Rat   326 TGAKVLIHQQNEYPFIEDVGMEIETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPVTN----IY 386

  Fly   341 YRIYTRLNCENECLAAFLYDTCSCIPFDHPLIYSNASICSMGDTSCVRRAQRASNRPGWAKCRQQ 405
            ...|:...|...|....:.:.|.|..:..||..: |:.|:.            ...|.|..|..|
  Rat   387 NAAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPA-ANYCNY------------QQHPNWMYCYYQ 438

  Fly   406 ---------------CLPSCF--DLNYLASGFSFPLASNNFQLANALV----ESFNKSYLSKNIA 449
                           |..||.  :.....|...:|..::...|.|.|.    :..||.....::|
  Rat   439 LYQAFVREELGCQSVCKQSCSFKEWTLTTSLAQWPSEASEKWLLNVLTWDQSQQINKKLNKTDLA 503

  Fly   450 VINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEIL--YFLILKPLAELFVWK 512
            .:.:::::.......::....:...|||.||.:||:|..||:.:.||:  :|:....:.....|.
  Rat   504 KLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWH 568

  Fly   513 RSSHVDSEKSLKHNAFGIEKGQSSDNPS 540
            ::....:.:....:.......|..|||:
  Rat   569 KAKDWWARRQTPPSTETPSSRQGQDNPA 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	106/570 (19%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	106/570 (19%)
Scnn1g	NP_058742.2	ENaC	24..631	CDD:273304	112/613 (18%)
Scnn1g	NP_058742.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..628		4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345667
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4773
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8907
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.700