Protein Alignment ppk12 and Scnn1b

DIOPT Version :10

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_036780.1
• Gene: Scnn1b / 24767
• RGDID: 3640
• Length: 638
• Species: Rattus norvegicus
• Alignment Length: 591
• Identity: 122/591 - (20%)
• Similarity: 208/591 - (35%)
• Gaps: 180/591 - (30%)

  Fly    29 FLNQTSLHGLKFV---GDSGLSSWERSFFLGSFVTALIITVH--LISNIYVKWDSTPVIIGISPQ 88
            :.|.|:.||.|.:   |....:.|    ||.:.:.|.::...  :....|:.|:   |.:.:|
  Rat    29 YCNNTNTHGPKRIICEGPKKKAMW----FLLTLLFACLVCWQWGVFIQTYLSWE---VSVSLS-- 84

  Fly    89 ATSILKVPFPAITICNMNQVQRSLVAN-----YREGSNESALLKLLCESDSWESSEADEEFSASN 148
             .....:.|||:|:||.:..|.|.|.:     |:  ..|:.|.|:|....|..::.:...|:..|
  Rat    85 -MGFKTMNFPAVTVCNSSPFQYSKVKHLLKDLYK--LMEAVLDKILAPKSSHTNTTSTLNFTIWN 146

  Fly   149 ---------------FVTNNLKISEFVSN-------HSQSCERMLLFC----------RFSAVER 181
                           .|.|....|...||       ::|.|:..:..|          .|::..:
  Rat   147 HTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMRLCSANGTVCTFRNFTSATQ 211

  Fly   182 --------NCSQLFQQILTDE----G-------LCCVFNFQPPEYLYKPFANNNRNLTNSDGFES 227
                    ..:.:|.|:|..:    |       |.|:|..:|         .::||.|
  Rat   212 AVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILACLFGTEP---------CSHRNFT------- 260

  Fly   228 VMWDPESGYPEQLPPKFYP----------------ATASGTGITLGFTAVLDAEMGEYYCSSTNG 276
                          |.|||                ..::..|...|...:||....:|.....:.
  Rat   261 --------------PIFYPDYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLAST 311

  Fly   277 PGFKVYFHNPIEVPKVKEAGLISAIGYETNYRI--EMVRAEAVPAIRSISRDGRQCLFKNEKELI 339
            .|.::..|.....|.::|.|:.:..|.||:..:  :.::.:..|.        ..|.. |..::.
  Rat   312 AGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLLDKLQGKGEPY--------SPCTM-NGSDVA 367

  Fly   340 FYRIYTRLN-------CENECLAAFLYDTCSCIPFDHPLIYSNASICSMGDTSCVRRAQRASNR- 396
            ...:|:..|       |.:.|....:...|||..:.:||        ..|:..|       :||
  Rat   368 IQNLYSDYNTTYSIQACLHSCFQDHMIHNCSCGHYLYPL--------PAGEKYC-------NNRD 417

  Fly   397 -PGWAKC----------RQQCL----PSCFDLNY--LASGFSFPLASNNFQLANALV----ESFN 440
             |.||.|          |:.||    .||.|..|  ..|...:|..::...:.:.|.    :|.|
  Rat   418 FPDWAYCYLSLQMSVVQRETCLSMCKESCNDTQYKMTISMADWPSEASEDWILHVLSQERDQSSN 482

  Fly   441 KSYLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEILYFLILKPL 505
            .:...|.|..:|:||:|..|....::....:...|||:||..|.:||.||:.|.|....:|
  Rat   483 ITLSRKGIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIII---- 543

  Fly   506 AELFVW 511
              .|:|
  Rat   544 --DFIW 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	ASC	29..499	CDD:459966	119/577 (21%)
Scnn1b	NP_036780.1	ENaC	21..621	CDD:273304	122/591 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	598..620
		PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:12654927, ECO:0000269|PubMed:8665844	614..618