DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and Scnn1b

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_036780.1	Gene:	Scnn1b / 24767	RGDID:	3640	Length:	638	Species:	Rattus norvegicus

Alignment Length:	591	Identity:	122/591 - (20%)
Similarity:	208/591 - (35%)	Gaps:	180/591 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 FLNQTSLHGLKFV---GDSGLSSWERSFFLGSFVTALIITVH--LISNIYVKWDSTPVIIGISPQ 88
            :.|.|:.||.|.:   |....:.|    ||.:.:.|.::...  :....|:.|:   |.:.:|
  Rat    29 YCNNTNTHGPKRIICEGPKKKAMW----FLLTLLFACLVCWQWGVFIQTYLSWE---VSVSLS-- 84

  Fly    89 ATSILKVPFPAITICNMNQVQRSLVAN-----YREGSNESALLKLLCESDSWESSEADEEFSASN 148
             .....:.|||:|:||.:..|.|.|.:     |:  ..|:.|.|:|....|..::.:...|:..|
  Rat    85 -MGFKTMNFPAVTVCNSSPFQYSKVKHLLKDLYK--LMEAVLDKILAPKSSHTNTTSTLNFTIWN 146

  Fly   149 ---------------FVTNNLKISEFVSN-------HSQSCERMLLFC----------RFSAVER 181
                           .|.|....|...||       ::|.|:..:..|          .|::..:
  Rat   147 HTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMRLCSANGTVCTFRNFTSATQ 211

  Fly   182 --------NCSQLFQQILTDE----G-------LCCVFNFQPPEYLYKPFANNNRNLTNSDGFES 227
                    ..:.:|.|:|..:    |       |.|:|..:|         .::||.|
  Rat   212 AVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILACLFGTEP---------CSHRNFT------- 260

  Fly   228 VMWDPESGYPEQLPPKFYP----------------ATASGTGITLGFTAVLDAEMGEYYCSSTNG 276
                          |.|||                ..::..|...|...:||....:|.....:.
  Rat   261 --------------PIFYPDYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLAST 311

  Fly   277 PGFKVYFHNPIEVPKVKEAGLISAIGYETNYRI--EMVRAEAVPAIRSISRDGRQCLFKNEKELI 339
            .|.::..|.....|.::|.|:.:..|.||:..:  :.::.:..|.        ..|.. |..::.
  Rat   312 AGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLLDKLQGKGEPY--------SPCTM-NGSDVA 367

  Fly   340 FYRIYTRLN-------CENECLAAFLYDTCSCIPFDHPLIYSNASICSMGDTSCVRRAQRASNR- 396
            ...:|:..|       |.:.|....:...|||..:.:||        ..|:..|       :||
  Rat   368 IQNLYSDYNTTYSIQACLHSCFQDHMIHNCSCGHYLYPL--------PAGEKYC-------NNRD 417

  Fly   397 -PGWAKC----------RQQCL----PSCFDLNY--LASGFSFPLASNNFQLANALV----ESFN 440
             |.||.|          |:.||    .||.|..|  ..|...:|..::...:.:.|.    :|.|
  Rat   418 FPDWAYCYLSLQMSVVQRETCLSMCKESCNDTQYKMTISMADWPSEASEDWILHVLSQERDQSSN 482

  Fly   441 KSYLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEILYFLILKPL 505
            .:...|.|..:|:||:|..|....::....:...|||:||..|.:||.||:.|.|....:|
  Rat   483 ITLSRKGIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIII---- 543

  Fly   506 AELFVW 511
              .|:|
  Rat   544 --DFIW 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	119/577 (21%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	119/577 (21%)
Scnn1b	NP_036780.1	ENaC	21..621	CDD:273304	122/591 (21%)
		deg-1	29..538	CDD:273309	118/574 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..620
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345643
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4773
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8907
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.700