DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and Asic4

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	XP_036020902.1	Gene:	Asic4 / 241118	MGIID:	2652846	Length:	586	Species:	Mus musculus

Alignment Length:	636	Identity:	136/636 - (21%)
Similarity:	225/636 - (35%)	Gaps:	192/636 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVKWDSTPVIIGISPQ 88
            |.|..|.:.::||||......|.....|:.:..:.:|:|...::..:::...:.:.|.::.:.|.
Mouse    40 RDLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAASLARGYLTRPHLVAMDPA 104

  Fly    89 ATSILKVPFPAITICNMNQVQRSLVANY---------------REGSNESALLKLLCESDSWESS 138
            |.:.: ..|||:|:||:|:.:.|.:::.               |:|...:.|          ...
Mouse   105 APAPV-AGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGL----------RYP 158

  Fly   139 EADEEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNCS-QLFQQILTDEGLCCVFNF 202
            |.|              :.:.::........||..|.||.  .:|| ..|..:.|..|.|..||.
Mouse   159 EPD--------------MVDILNRTGHQLADMLKSCNFSG--HHCSASNFSVVYTRYGKCYTFNA 207

  Fly   203 QPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLDAEMG 267
                                        ||:|..|.:         |.|.|  .|...:||.:..
Mouse   208 ----------------------------DPQSSLPSR---------AGGMG--SGLEIMLDIQQE 233

  Fly   268 EY--YCSSTN----GPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPAIRSISRD 326
            ||  ....||    ..|.:|..|:..|.|.:.:.|...:.|::|....:..|...:|      :.
Mouse   234 EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLP------QP 292

  Fly   327 GRQCLFKN---EKELIFYRIYT----RLNCENECLAAFLYDTCSC----IPFDHPLIYSNASICS 380
            ...|..::   |.||..|..|:    ||.||.|.    :...|.|    :|..|......|::.|
Mouse   293 WGNCRAESELREPELQGYSAYSVSACRLRCEKEA----VLQRCHCRMVHMPGGHLQPVFGATLLS 353

  Fly   381 MGDTSCVRRAQRAS------------NRPGWAKCRQQ--CLPS----CFD--LNYLASGFSFP-- 423
             ..||..:|..|.:            ...|:.....:  |.|:    |.|  |:.|..|...|
Mouse   354 -SRTSRRQRCMRTTCTRIYTHERVLMCMSGYLHMGNETICPPNIYIECADHTLDSLGGGSEGPCF 417

  Fly   424 ----------------LASNNFQLANALVESFNK--SYLSKNIAVINVYFRESVYYGNTKNAYVG 470
                            :...|...|..|...:|:  :|:.:|..|::|:|.........:.|..|
Mouse   418 CPTPCNLTRYGKEISMVKIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQQAAYG 482

  Fly   471 LTEFLSNVGGVMGLFMGFSVISLAEILYFLI------LKPLAELFVWKRSSHVDSEKSLKHNAFG 529
            |:..|.::||.||||:|.|:::|.|||.::.      ||.     ||:|     .:..|:.:..|
Mouse   483 LSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKR-----VWRR-----PKTPLRTSTGG 537

  Fly   530 IEK---------------------GQSSDNPSFWHSKELYPKGVSISAYEN 559
            |..                     |.||..|:..|     |.|...|.:|:
Mouse   538 ISTLGLQELKEQSPCPSRGRAEGGGASSLLPNHHH-----PHGPPGSLFED 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	117/543 (22%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	117/542 (22%)
Asic4	XP_036020902.1	ASC	40..535	CDD:413546	125/581 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842241
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8693
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.740