Protein Alignment ppk12 and Asic4

DIOPT Version :10

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: XP_036020902.1
• Gene: Asic4 / 241118
• MGIID: 2652846
• Length: 586
• Species: Mus musculus
• Alignment Length: 636
• Identity: 136/636 - (21%)
• Similarity: 225/636 - (35%)
• Gaps: 192/636 - (30%)

  Fly    24 RSLRQFLNQTSLHGLKFVGDSGLSSWERSFFLGSFVTALIITVHLISNIYVKWDSTPVIIGISPQ 88
            |.|..|.:.::||||......|.....|:.:..:.:|:|...::..:::...:.:.|.::.:.|.
Mouse    40 RDLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAASLARGYLTRPHLVAMDPA 104

  Fly    89 ATSILKVPFPAITICNMNQVQRSLVANY---------------REGSNESALLKLLCESDSWESS 138
            |.:.: ..|||:|:||:|:.:.|.:::.               |:|...:.|          ...
Mouse   105 APAPV-AGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGL----------RYP 158

  Fly   139 EADEEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNCS-QLFQQILTDEGLCCVFNF 202
            |.|              :.:.::........||..|.||.  .:|| ..|..:.|..|.|..||.
Mouse   159 EPD--------------MVDILNRTGHQLADMLKSCNFSG--HHCSASNFSVVYTRYGKCYTFNA 207

  Fly   203 QPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLDAEMG 267
                                        ||:|..|.:         |.|.|  .|...:||.:..
Mouse   208 ----------------------------DPQSSLPSR---------AGGMG--SGLEIMLDIQQE 233

  Fly   268 EY--YCSSTN----GPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPAIRSISRD 326
            ||  ....||    ..|.:|..|:..|.|.:.:.|...:.|::|....:..|...:|      :.
Mouse   234 EYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLP------QP 292

  Fly   327 GRQCLFKN---EKELIFYRIYT----RLNCENECLAAFLYDTCSC----IPFDHPLIYSNASICS 380
            ...|..::   |.||..|..|:    ||.||.|.    :...|.|    :|..|......|::.|
Mouse   293 WGNCRAESELREPELQGYSAYSVSACRLRCEKEA----VLQRCHCRMVHMPGGHLQPVFGATLLS 353

  Fly   381 MGDTSCVRRAQRAS------------NRPGWAKCRQQ--CLPS----CFD--LNYLASGFSFP-- 423
             ..||..:|..|.:            ...|:.....:  |.|:    |.|  |:.|..|...|
Mouse   354 -SRTSRRQRCMRTTCTRIYTHERVLMCMSGYLHMGNETICPPNIYIECADHTLDSLGGGSEGPCF 417

  Fly   424 ----------------LASNNFQLANALVESFNK--SYLSKNIAVINVYFRESVYYGNTKNAYVG 470
                            :...|...|..|...:|:  :|:.:|..|::|:|.........:.|..|
Mouse   418 CPTPCNLTRYGKEISMVKIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQQAAYG 482

  Fly   471 LTEFLSNVGGVMGLFMGFSVISLAEILYFLI------LKPLAELFVWKRSSHVDSEKSLKHNAFG 529
            |:..|.::||.||||:|.|:::|.|||.::.      ||.     ||:|     .:..|:.:..|
Mouse   483 LSALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDRLKR-----VWRR-----PKTPLRTSTGG 537

  Fly   530 IEK---------------------GQSSDNPSFWHSKELYPKGVSISAYEN 559
            |..                     |.||..|:..|     |.|...|.:|:
Mouse   538 ISTLGLQELKEQSPCPSRGRAEGGGASSLLPNHHH-----PHGPPGSLFED 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	ASC	29..499	CDD:459966	117/542 (22%)
Asic4	XP_036020902.1	ENaC	40..535	CDD:273304	125/581 (22%)