Protein Alignment ppk12 and Scnn1b

DIOPT Version :10

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: NP_035455.1
• Gene: Scnn1b / 20277
• MGIID: 104696
• Length: 638
• Species: Mus musculus
• Alignment Length: 647
• Identity: 138/647 - (21%)
• Similarity: 227/647 - (35%)
• Gaps: 198/647 - (30%)

  Fly    29 FLNQTSLHGLKFV---GDSGLSSWERSFFLGSFVTALIITVH--LISNIYVKWDSTPVIIGISPQ 88
            :.|.|:.||.|.:   |....:.|    ||.:.:.|.::...  :....|:.|:   |.:.:|
Mouse    29 YCNNTNTHGPKRIICEGPKKKAMW----FLLTLLFACLVCWQWGVFIQTYLSWE---VSVSLS-- 84

  Fly    89 ATSILKVPFPAITICNMNQVQRSLVANYREGSN---ESALLKLLCESDSWESSEADEEFSASN-- 148
             .....:.|||:|:||.:..|.|.|.:..:..:   |:.|.|:|....|..::.....|:..|
Mouse    85 -MGFKTMNFPAVTVCNSSPFQYSKVKHLLKDLDELMEAVLEKILAPEASHSNTTRTLNFTIWNHT 148

  Fly   149 -------------FVTNNLKISEFVSN-------HSQSCERMLLFC----------RFSAVER-- 181
                         .|.|....|...||       ::|.|:..:..|          .|::..:
Mouse   149 PLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMRLCSANGTVCTLRNFTSATQAV 213

  Fly   182 ------NCSQLFQQILTDE----G-------LCCVF--------NFQP---PEYLYKPFANNNRN 218
                  ..:.:|.|:|..:    |       |.|:|        ||.|   |:|       .|..
Mouse   214 TEWYILQATNIFSQVLPQDLVGMGYAPDRIILACLFGTEPCSHRNFTPIFYPDY-------GNCY 271

  Fly   219 LTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLDAEMGEYYCSSTNGPGFKVYF 283
            :.|        |    |..|:..|...|      |...|...:||....:|.....:..|.::..
Mouse   272 IFN--------W----GMTEETLPSANP------GTEFGLKLILDIGQEDYVPFLASTAGARLML 318

  Fly   284 HNPIEVPKVKEAGLISAIGYETN--YRIEMVRAEAVPAIRSISRDGRQCLFKNEKELIFYRIYTR 346
            |.....|.::|.|:.:..|.||:  ..::.::.:..| ....:.:|.....||     .|.:|..
Mouse   319 HEQRTYPFIREEGIYAMAGTETSIGVLVDKLQRKGEP-YSPCTMNGSDVAIKN-----LYSVYNT 377

  Fly   347 L----NCENECLAAFLYDTCSCIPFDHPLIYSNASICSMGDTSCVRRAQRASNR--PGWAKC--- 402
            .    .|.:.|....:...|||..:.:||        ..|:..|       :||  |.||.|
Mouse   378 TYSIQACLHSCFQDHMIRNCSCGHYLYPL--------PEGEKYC-------NNRDFPDWAYCYLN 427

  Fly   403 -------RQQCL----PSCFDLNY--LASGFSFPLASNNFQLANALV----ESFNKSYLSKNIAV 450
                   |:.||    .||.|..|  ..|...:|..::...:.:.|.    :|.|.:...|.|..
Mouse   428 LQMSVTQRETCLSMCKESCNDTQYKMTISMADWPSEASEDWILHVLSQERDQSSNITLSRKGIVK 492

  Fly   451 INVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAE-------ILYFLILKPLAEL 508
            :|:||:|..|....::....:...|||:||..|.:||.||:.|.|       .::..|:|.:|
Mouse   493 LNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITIIKLVA-- 555

  Fly   509 FVWKRSSHVDSEKSLK---------------------HNAFGIEKGQSSDNPSFWHSKELYP 549
                      |.|.|:                     |..||.:...:|..|   |. |:||
Mouse   556 ----------SCKGLRRRRPQAPYTGPPPTVAELVEAHTNFGFQPDTTSCRP---HG-EVYP 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	ASC	29..499	CDD:459966	123/574 (21%)
Scnn1b	NP_035455.1	ENaC	21..621	CDD:273304	138/647 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	594..620		6/14 (43%)
		PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P51168	614..618