DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk12 and asic-1

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_491214.3	Gene:	asic-1 / 191422	WormBaseID:	WBGene00022815	Length:	823	Species:	Caenorhabditis elegans

Alignment Length:	413	Identity:	91/413 - (22%)
Similarity:	152/413 - (36%)	Gaps:	103/413 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 LCESDSWESSEADEEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNCSQLFQQILTD 193
            |.|.:.|:.|     ::.|:|:                     :.|.|:..|.|....|.:.|..
Worm   475 LTEEEKWKIS-----YNKSDFI---------------------MKCSFNGRECNVKHDFVEYLDP 513

  Fly   194 E-GLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLG 257
            . |.|         :.|.....||.|                   |:..|.:        |:.|.
Worm   514 TYGAC---------FTYGQKLGNNTN-------------------ERSGPAY--------GLRLE 542

  Fly   258 -FTAVLDAEMGEYYCSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPA-I 320
             |..|.:      |..:|...|.::..|...|.|.....|..:..|:.:::.|::.....:|| .
Worm   543 VFVNVTE------YLPTTEAAGVRLTVHATDEQPFPDTLGFSAPTGFVSSFGIKLKSMVRLPAPY 601

  Fly   321 RSISRDGRQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSC-IPFDHPLIYSNASICSMGD- 383
            ....|:|     |.|..:...:.|....|:..|:...|..||.| .|...|  |..:..|.:.|
Worm   602 GDCVREG-----KTEDFIYTQKAYNTEGCQRSCIQKHLSKTCGCGDPRFPP--YRESKNCPVDDP 659

  Fly   384 --TSCVRR----AQRASNRPGWAKCRQQCLPSCFDLNYLASGFSFPLASNNFQ---LANALVESF 439
              ..|::.    |.|.|.:.| ..|:|.|....:.::|.||  .:|..:.:..   |..|.....
Worm   660 YKRECIKNEMHVATRDSKKLG-CSCKQPCNQDVYSVSYSAS--RWPAIAGDLSGCPLGMAAHHCL 721

  Fly   440 NKSYLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEILYFLILKP 504
            |  |..:..::|.|||.:..|....::...|.:..||:.||.:||:||.|||::.|:..|..
Worm   722 N--YKREQGSMIEVYFEQLNYESLLESEAYGWSNLLSDFGGQLGLWMGVSVITIGEVACFFF--- 781

  Fly   505 LAELFVWKRSSHVDSEKSLKHNA 527
              |:|:    |.:.|.::.:..|
Worm   782 --EVFI----SLISSNRTKRRPA 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	85/383 (22%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	85/383 (22%)
asic-1	NP_491214.3	deg-1	16..779	CDD:273309	85/383 (22%)
		ASC	17..>104	CDD:279230
		ASC	<469..788	CDD:295594	89/401 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I4100
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	107	1.000	Inparanoid score	I3493
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.770