DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk12 and degt-1

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_505703.3	Gene:	degt-1 / 184921	WormBaseID:	WBGene00009109	Length:	852	Species:	Caenorhabditis elegans

Alignment Length:	580	Identity:	110/580 - (18%)
Similarity:	204/580 - (35%)	Gaps:	153/580 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 FVRSLRQFLNQTSLHGLKFVGDSGLSSWER-------SFFLGSFVTALI--ITVHLISNIYVKWD 77
            ::.:|.:|...||:.|.::: .:...:|.|       .||:|.....:.  :|.:.|.|
Worm    37 YIPALDRFAEDTSMLGFRYL-HTRYKTWFRVLWGFVVVFFIGLTFYQVFERVTYYFIKN------ 94

  Fly    78 STPVIIGISPQAT-----SILKVPFPAITICNMNQVQRSLVANYREGSNESALLKLLC---ESDS 134
                     |..|     ::..:.||.|.:||..|::.|.||     |....||:.:|   :..|
Worm    95 ---------PLTTRRSYETLPNMYFPTIGVCNKMQIKASSVA-----SKNPDLLRGMCSVLDESS 145

  Fly   135 WESSEADEEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNCSQLFQQILTDEGLCCV 199
            ..||..||   ...|  :::.|.....|..||.:.:.:.|.|.. ..:|....:.|.|..|||
Worm   146 SNSSRFDE---LDKF--DDVDILSLYRNSFQSADDLFVSCEFGK-SGSCQDEIRPIYTPFGLC-- 202

  Fly   200 FNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFTAVLDA 264
            ::..|.:.:.:|                   .||:                    ||  :.||:.
Worm   203 YSVSPNKTILRP-------------------GPET--------------------TL--SLVLNL 226

  Fly   265 EMGEYYCSSTNGPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRIEMVRAEAVPA--IRSISRDG 327
            |:.|....:...||..:..::          |..|...|.....:|..:...:|.  :|.:....
Worm   227 EVHEIIPGTVVEPGVVLSIYD----------GASSLSHYSEGIHLEAGKVVTIPVNEVRKLRLHE 281

  Fly   328 RQCLFKNEKELIFYRIYTRLNCENECLAAFLYDTCSCIPFDHPL---IYSNASICSMGDTSCVRR 389
            ..| ...:.|....:.|::..||.......:...|.|||..:|:   ::.|.:......|...::
Worm   282 SSC-GSTKMESFSEKEYSKAACEWSVSVKQIEKECGCIPIRNPIYRGVFDNKNDPLNNSTEIPKK 345

  Fly   390 AQRASNRPGWAKC--RQQ------------------CLPSCFDLNYLASGFSFPLASNNFQLANA 434
            ..:...:....:|  ||:                  |...|.|:::.:..|...|:|:  ::.:.
Worm   346 KYKKWKKRNIPRCTLRQEIECVQEKLNIRPHIDDSICPDDCDDISFSSIVFGGKLSSS--EIVSM 408

  Fly   435 LVESFNKSYLSKNIA----VINVYFRESV-YYGNTKNAYVGLTEFL---SNVGGVMGLFMGFSVI 491
            |...:..: ..|.:|    |:.|...:.: ...|.:.....|..|:   |.:.||...|.....:
Worm   409 LPSDWEDT-KEKRVADYQKVLEVIPNKMIPVVRNVQQLADELQLFVKEASEIFGVSDNFHDVKCL 472

  Fly   492 SLAEILY------FLILKPLAELFVWKR-SSHVDSEKSLKHNA-------FGIEKGQSSD 537
            ||....|      |...:|     .|:| ::::....:.:.|:       |..|||:..|
Worm   473 SLDGRTYESFINQFYSYEP-----TWERITTYLQHSLARELNSTALCLGLFLTEKGEIDD 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	99/526 (19%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	99/525 (19%)
degt-1	NP_505703.3	ASC	44..>318	CDD:279230	69/354 (19%)
degt-1	NP_505703.3	ASC	<704..836	CDD:295594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810