DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and delm-1

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_501590.2	Gene:	delm-1 / 184882	WormBaseID:	WBGene00009073	Length:	626	Species:	Caenorhabditis elegans

Alignment Length:	534	Identity:	119/534 - (22%)
Similarity:	202/534 - (37%)	Gaps:	129/534 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SFVRSLRQFLNQTSLHGLKFVGDSGLSSWERSFF----LGSFVTALIITVHLISNIYVKWDSTPV 81
            |..|..:.|...|::||.|.: ..|...:.:.|:    ||| :..||....::|..|:   |.|:
Worm    65 SVKRETQHFCETTTMHGPKRI-FKGKRIFTKLFWLIMVLGS-LGLLIYQCWILSASYL---SKPI 124

  Fly    82 IIGISPQATSILKVP-----FPAITICNMNQVQRSLV-ANYREGSNESALLK-----------LL 129
            :..:|      ..:|     ||::|:||...:::|.: |..|.|.....::.           ||
Worm   125 VSQVS------FLIPEDGMEFPSVTVCNFTPIRKSYIEAMNRTGDVSPDMINYLMNWFTEIPILL 183

  Fly   130 CESDSWESSEADEEFSASNFVTNNLKISEFVSNHSQSCERMLLFCRFSAVERNCSQLFQQILTDE 194
            ..:|....::.:||......:..|..:.:|..:.|..|..::..|.|.....:|..|....||..
Worm   184 GNTDQQSLNKGNEELREYQSIHPNFTVDQFFMDASFDCSDLMKLCSFQGESFDCCSLASPTLTPV 248

  Fly   195 GLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKFYPATASGTGITLGFT 259
            |.|...:..                             :|...:|..|          ||..|.:
Worm   249 GKCFTLDLS-----------------------------KSPMNKQTEP----------GIRAGLS 274

  Fly   260 AVLDAEMGEYYCSSTN---------GPGFKVYFHNPIEVPKVKEAGLISAIGYETNYRI--EMVR 313
            ..|||.:.|.:.|||.         ..||:.:.|....:|.:.          ...|.:  ..|.
Worm   275 LTLDANLDEQFDSSTGIDALLPNSFVNGFRYFVHPKDTIPNLA----------SDEYTVSPNSVA 329

  Fly   314 AEAVPAIRSI---SRDGRQCLFKNEKELIFYRI-----YTRLNCENECLAAFLYDTCSCIPFDHP 370
            ..|:...|.:   ..|...|     .|...|.|     ||..||.:.|.|.:..:.|.|.    |
Worm   330 YSAISKFRYVLLPPNDWGNC-----TEDYPYGIQSNLSYTSGNCLSLCKAKYFMNQCGCT----P 385

  Fly   371 LIY---SNASICSMGDT-SCVRRAQRASNR---------PGWAKCRQQCLPSCFDLNYLASGFSF 422
            .:|   :|...|:..:| :||..:....|.         |...:|.|||....:..:. ::|..|
Worm   386 ALYNIGNNFQECTPFETYNCVNNSLSLLNEETGKMEFQPPSCTRCGQQCDSQVYRADN-SNGNQF 449

  Fly   423 PLASNNFQLANALVESFNKSYLSKNIAVINVYFRESVY--YGNTKNAYVGLTEFLSNVGGVMGLF 485
              ::..|...|:...|::..|:..|..:|.:::|:..|  |...::|  .:|:.||.:||.||:|
Worm   450 --SAGAFNYFNSKNSSWSVDYMKSNFQMIRIFYRDMSYTEYNQVQDA--SITDLLSAIGGNMGMF 510

  Fly   486 MGFSVISLAEILYF 499
            :|.|||::.|:..|
Worm   511 LGGSVITIVELFLF 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	116/525 (22%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	116/524 (22%)
delm-1	NP_501590.2	ASC	73..524	CDD:279230	116/524 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162345
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28677
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14160
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3550
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.790