DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk12 and acd-2

DIOPT Version :9

Sequence 1:	NP_611672.1	Gene:	ppk12 / 37566	FlyBaseID:	FBgn0034730	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_001309477.1	Gene:	acd-2 / 171992	WormBaseID:	WBGene00016066	Length:	693	Species:	Caenorhabditis elegans

Alignment Length:	573	Identity:	127/573 - (22%)
Similarity:	227/573 - (39%)	Gaps:	132/573 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RQGSSLFLLKSFVRSLRQFLNQTSLHGLK--FVGDSGLSSWERSFFL---GSFVTALIITVHLIS 70
            :.|..:..:.|..|..:.|.:.|::||.|  |.| .|::   |:|::   |..:..|...:.::.
Worm    65 KNGKKIKGVGSAFRETKHFSSTTTMHGPKRIFYG-KGVA---RAFWMLIVGLALAMLCFQIFILL 125

  Fly    71 NIYVKWDSTPVIIGISPQATSILK---VPFPAITICNMNQVQRSLVANYR-EGSNESALLKLLCE 131
            .:|.   |.|.:    .|.:.|:.   :.|||:|:||.|.:::|.|.... .|......|:.|.:
Worm   126 QMYF---SKPTL----SQVSFIVNEGGMDFPAVTVCNFNPIKKSYVRELNVSGDLTGETLEYLLQ 183

  Fly   132 SDSWESSEADEEFSASNFVTNNLK-----------------ISEFVSNHSQSCERMLLFCRFSAV 179
            ::      .|..|..||...:|||                 |.:|:......|..|.:.|.|...
Worm   184 TN------MDAMFLFSNLDRHNLKETHDEAETYFQNHTDFQIIKFLRTAGYDCGEMFMTCYFGGR 242

  Fly   180 ERNCSQLFQQILTDEGLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPESGYPEQLPPKF 244
            ..:|.:..:|.:|..|.|...:.              |||.                ||.:..:.
Worm   243 RFDCCKYMKQKVTSLGKCWELDL--------------RNLA----------------PEWMRKQI 277

  Fly   245 YPATASGTGITLGFTAVLDAEMGEYYCSSTNGP----------GFKVYFHNPIEVPKVKEAGLIS 299
            .|.:.:|..|      |:||::.|......:..          ||:.:.|.|....::...| ||
Worm   278 SPGSEAGLQI------VVDAQLEEELKGENDDAKAIFSDIYENGFRYFIHPPGTNAQLTSEG-IS 335

  Fly   300 AIGYETNYRIEMVRAEAVPAIRSISRD----GR--QCLFKNEKELIFYRIYTRLNCENECLAAFL 358
            .....|.|          .||::::.:    |.  .|.....:....:..|:...|...|:|.|.
Worm   336 VSPSRTVY----------SAIKTVTHNLLNRGNWGNCSENWPEGYNTFLSYSASACRALCIAQFF 390

  Fly   359 YDTCSCIPFDHPLIYSNASIC------SMGDTSCVRRAQRAS--NRPGWAKCRQQCLPSCFDLNY 415
            .|||.|.||.:. :.....||      :..|...:::.....  ..|...:|..:|..:.: .:|
Worm   391 NDTCGCAPFTYN-VDGRKKICAPYESITCMDNHMLKKVNGTDYLELPDCEECHMECQSTSY-TSY 453

  Fly   416 LASGFSFPLASNNFQLANALVESFNKS--YLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNV 478
            .:.|..|...|..:     |.:..|||  ::..|:||||::|.|..|...::.....|||.||::
Worm   454 NSYGDGFNRGSLEW-----LKKISNKSETHIKNNVAVINIFFLEMFYTSYSQVQATSLTEILSDI 513

  Fly   479 GGVMGLFMGFSVISLAEI------LYFLILKPLAELFVWKRSSHVDSEKSLKH 525
            ||.||:|:|.|||::.|:      ::::::......:::.:.:|   ||..:|
Worm   514 GGNMGMFLGMSVITITELSLFFSKIFWIMVSKRRRQYMYSKKTH---EKEKEH 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	deg-1	28..499	CDD:273309	120/528 (23%)
ppk12	NP_611672.1	ASC	29..499	CDD:279230	120/527 (23%)
acd-2	NP_001309477.1	ASC	83..531	CDD:279230	119/518 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162307
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7217
OMA	1	1.010	-	-		QHG28677
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14160
orthoMCL	1	0.900	-	-		OOG6_100105
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.710