Protein Alignment ppk12 and Asic3

DIOPT Version :10

• Sequence 1: NP_611672.1
• Gene: ppk12 / 37566
• FlyBaseID: FBgn0034730
• Length: 569
• Species: Drosophila melanogaster
• Sequence 2: XP_006535700.1
• Gene: Asic3 / 171209
• MGIID: 2159339
• Length: 563
• Species: Mus musculus
• Alignment Length: 602
• Identity: 134/602 - (22%)
• Similarity: 219/602 - (36%)
• Gaps: 186/602 - (30%)

  Fly     5 PSAGTE----RQGSSLFLLKSFVRSLRQFLNQTSLHGLKFV-GDSGLSSWERSFFLGSFVTALII 64
            |.:|.|    ||.|          .:|.|.|..::|||..: |..||     :...|.:.||:::
Mouse     3 PPSGLEEAQRRQAS----------DIRVFANSCTMHGLGHIFGPGGL-----TLRRGLWATAVLL 52

  Fly    65 TVHLISNIY-----VKW-----DSTPVIIGISPQATSILKVPFPAITICNMNQVQRSLVANYREG 119
            :  |.:.:|     |::     ..|.:....|.|.|      |||:|:||:|.::||     |..
Mouse    53 S--LAAFLYQVAERVRYYGEFHHKTTLDERESHQLT------FPAVTLCNINPLRRS-----RLT 104

  Fly   120 SNE-----SALLKLLCESDSWESS---------EADEEFSASNFVTNNLKISEFVSNHSQSCERM 170
            .|:     :|||.|    |..|.:         .|...|..|    ....:::..:....|.|.|
Mouse   105 PNDLHWAGTALLGL----DPAEHAAYLRALGQPPAPPGFMPS----PTFDMAQLYARAGHSLEDM 161

  Fly   171 LLFCRFSAVERNCS-QLFQQILTDEGLCCVFNFQPPEYLYKPFANNNRNLTNSDGFESVMWDPES 234
            ||.||:..  :.|. :.|..|.|..|.|..||                  :.:.|.| ::..|:.
Mouse   162 LLDCRYRG--QPCGPENFTVIFTRMGQCYTFN------------------SGAQGAE-LLTTPKG 205

  Fly   235 GYPEQLPPKFYPATASGTGITLGFTAVLDAEMGEY---YCSSTNGP---GFKVYFHNPIEVPKVK 293
            |              :|.|:.:    :||.:..||   :......|   |.:|..|...|.|.:.
Mouse   206 G--------------AGNGLEI----MLDVQQEEYLPIWKDMEETPFEVGIRVQIHGQEEPPAID 252

  Fly   294 EAGLISAIGYETNYRIEMVRAEAVPA------IRSISRDGRQCLFKNEK-----ELIFYRIYTRL 347
            :.|..:|.|::|....:..:...:|.      ..|:..|     |..|.     .......|:.:
Mouse   253 QLGFGAAPGHQTFVSCQQQQLSFLPPPWGDCNTASVDPD-----FDPEPSDPLGSPSSSPPYSLI 312

  Fly   348 NCENECLAAFLYDTCSCIPFDHPLIYSNASICSMGDTSCVRRAQRASNRPGWAKCRQQCLP---- 408
            .|...|.:.::...|.|.....|   .|:.:||       .:..:....|...|.....||
Mouse   313 GCRLACESRYVARKCGCRMMHMP---GNSPVCS-------PQQYKDCASPALGKAHLFSLPVPIH 367

  Fly   409 SCFDLNYLASGFSF-------------------PLASNNF------------QLANALVESFNKS 442
            |..|.|.|.....|                   |.|:..:            ..|..|...:|:|
Mouse   368 SDIDHNPLGQVLLFLALRPADAMLRKDTCVCPNPCATTRYAKELSMVRIPSRASARYLARKYNRS 432

  Fly   443 --YLSKNIAVINVYFRESVYYGNTKNAYVGLTEFLSNVGGVMGLFMGFSVISLAEILYFLILKPL 505
              |:::|:.|::::|....|....:.|...::|.|.::||.||||:|.|::::.|||.:     |
Mouse   433 ETYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFIGASLLTILEILDY-----L 492

  Fly   506 AELF-------VWKRSS 515
            .|:|       .|.|.|
Mouse   493 CEVFQDRVLGYFWNRRS 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk12	NP_611672.1	ASC	29..499	CDD:459966	121/549 (22%)
Asic3	XP_006535700.1	ENaC	21..546	CDD:273304	127/574 (22%)